A5059699955- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Body Composition Measurement Techniques
- Fatty Acid Research and Health
- Health disparities and outcomes
- Health and Well-being Studies
- Hearing Loss and Rehabilitation
- Work-Family Balance Challenges
- Health and Wellbeing Research
- Adipose Tissue and Metabolism
- Nutrition, Health and Food Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Regulation of Appetite and Obesity
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological Disease Mechanisms and Treatments
- Workaholism, burnout, and well-being
National Center for Geriatrics and Gerontology
2016-2025
Aichi Shukutoku University
2018
Nagoya University of Arts and Sciences
2018
Osaka Prefecture University
2017
Otsuka (Japan)
2014
University of California, San Diego
2013
GGG (France)
2013
Nagoya University
2003-2009
Nagoya City University
2006
The gait speed and handgrip strength represented the core determinants of physical frailty sarcopenia, which were reported to be associated with cognitive impairment decline. Different measures might differentially affect changes, such as higher-level change global This study examined differential associations 10-year changes among community-dwelling older people.Participants aged 60 years over living in community invited for study. Gait classified into 5 groups based on quintiles at...
We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild impairment (MCI).
Few epidemiologic studies have examined the association between rate of eating and obesity. In this study, we cross-sectionally self-reported with current Body Mass Index (BMI), BMI-change from 20 years age to age.Subjects were 3737 male (mean +/- standard deviation mean BMI deviation: 48.2 7.1 23.3 2.7 kg/m(2)) 1005 female (46.3 7.0 21.8 2.8 Japanese civil servants. We measured categorical eating, BMI, at 20, 20. Energy intake was assessed over a 1-month period brief-type diet history...
Background— Anti-inflammatory and proinflammatory molecules purportedly play an important role in developing metabolic syndrome (MetS). However, little is known as to the relative importance of these association with MetS. Methods Results— We studied 624 middle-aged Japanese men without medical history cardiovascular disease or cancer investigated associations circulating tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin used respective definitions...
The present study aimed to evaluate age-related changes in skeletal muscle mass among community-dwelling middle-aged and elderly Japanese.This 12-year longitudinal of a population Japan included 15,948 examinations 1962 men 1990 women. We assessed appendicular (AMM) using dual X-ray absorptiometry calculated the index (SMI) AMM divided by height squared (kg/m(2) ). Low was defined as minus two standard deviations below mean for young healthy adults. Leg extension power (watts) measured an...
To clarify the effectiveness of dietary diversity, calculated by records, on cognitive decline.Data were derived from National Institute for Longevity Sciences - Longitudinal Study Aging. Participants comprised 298 men and 272 women aged 60-81 years at baseline (second wave) who participated in follow-up study (third to seventh least once. Cognitive function was assessed with Mini-Mental State Examination all waves. Dietary diversity determined using Quantitative Index Diversity based a...
This study aimed to investigate the association between abdominal adiposity and change in cognitive function community-dwelling older adults.
Background: Diet is a modifiable factor that may affect sleep, but the associations of macronutrient intakes with insomnia are inconsistent. We investigated protein, fat, and carbohydrate symptoms.Methods: In this cross-sectional analysis 4435 non-shift workers, were assessed by brief-type self-administered diet history questionnaire, which requires recall usual 58 foods during preceding month. Presence symptoms, including difficulty initiating sleep (DIS), maintaining (DMS), poor quality...
Background: Skipping breakfast has been suspected as a risk factor for type 2 diabetes (T2DM), but the associations are not entirely consistent across ethnicities or sexes, and issue adequately addressed in Japanese population.Methods: We followed 4631 participants (3600 men 1031 women) work-site cohort of aged 35–66 years 2002 through 2011 T2DM development. Frequency eating was self-reported subsequently dichotomized to skippers, who eat 3–5 times/week less, eaters. Cox proportional hazards...
Components of physical frailty cluster into subtypes, but it remains unknown how these might be associated with age-related functional declines and multimorbidities. This study aims to investigated associations subtypes multimorbidity in a 10 year longitudinal cohort survey.Complementary used group-based multitrajectory modelling verify whether discovered Taiwan are presented another aging cohort, then cognitive decline multimorbidity. Participants aged ≥50 years were recruited from the...
Abstract Background Vitamin D is an essential nutrient in musculoskeletal function; however, its relationship to sarcopenia remains ambiguous, and the mechanisms targets of vitamin activity have not been elucidated. This study aimed clarify role mature skeletal muscle with sarcopenia. Methods epidemiological included 1653 community residents who participated both fifth seventh waves National Institute for Longevity Sciences, Longitudinal Study Aging had complete background data. Participants...
We assessed longitudinal relationships between baseline testosterone and muscle mass changes in Japanese men. Data were collected from community-dwelling 957 adult men who participated a study of ageing biennially 1997–2010. Appendicular (AMM) was measured with dual-energy X-ray absorptiometry at follow-up examinations. The cut-off point sarcopenia defined as skeletal index (AMM/height2) < 6.87 kg/m2. Total (TT) free (FT) radioimmunoassay. calculated FT (cFT) determined formula using...
Classic "position-effect" experiments repositioned genes near telomeres to demonstrate that the epigenetic landscape can dramatically alter gene expression. Here, we show systematic knockout collections provide an exceptional resource for interrogating position effects, not only but at every genetic locus. Because a single reporter replaces each deleted gene, this provides sensitive probe into different chromatin environments while controlling context. Using approach, find that, whereas...
A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in research expanded to brain imaging analyses with auditory function. The aim this study was investigate the link between ability, which assessed using pure-tone audiometry, volume regions, specifically hippocampus, entorhinal cortex, Heschl's gyrus, total gray matter, Freesurfer software T1-weighted magnetic resonance imaging. data for 2082 samples (age range = 40-89 years) were...
The relationship between physical frailty and regional gray matter volume in the brain was investigated among community-dwelling older Japanese people.Participants (N = 835; age range 65-89 years) were adults Obu City Higashiura Town Aichi Prefecture, Japan. Physical determined by modified criteria of Cardiovascular Health Study, which included weight loss, slowness, weakness, exhaustion, low activity. Regional volumes evaluated from 3-dimensional T1-weighted magnetic resonance images...
Hearing impairment (HI) is a major global health concern. In addition, social networks are important for healthy aging. This study aimed to examine the association between HI and relationships. was conducted by National Institute Longevity Sciences as part of its Longitudinal Study Aging with 1176 Japanese participants aged 60 years or older (mean age 71.0 ± 7.4). The convoy model used evaluate participants' network size. A pure-tone average hearing level (HL) 0.5, 1, 2, 4 kHz in better ear...
We examined associations between dietary diversity and all-cause cause-specific mortality in 386 men 413 women (age range, 60–79 years at baseline) who took part the National Institute for Longevity Sciences-Longitudinal Study of Aging study from 1997 to 2000. Dietary intake was assessed using three-day records photographs. The Quantitative Index Diversity used determine among thirteen food groups. score each were by sex-stratified tertiles, hazard ratios (HR) calculated compare risk deaths...
During the last three decades, Japan has become one of world's top countries for longevity, and increase in average life expectancy is accompanied by a sharp rise older population 65 years age above to ∼28%. This study aimed examine changes major health-related measures, including physical constitution, function, functional capacity community-dwelling Japanese people decade. From data 13 longitudinal cohort studies on aging conducted with total 13,441 subjects, this analyzed six indices that...
Abstract Background Although muscle quality evaluations are currently considered important for diagnosing sarcopenia, data from the general population lacking. This study used mid‐thigh computed tomography measurements to evaluate age‐related and sex‐related differences in quadriceps femoris mass their relationships with knee extension strength (KES). Methods Cross‐sectional 520 Japanese individuals (273 men 247 women, mean age: 63.1 ± 10.6 years) were analysed. Mass assessed using...
Social support is associated with multiple positive health outcomes and negatively frailty in older adults. However, most evidence came from cross-sectional research. This study aimed to longitudinally explore the relationship between different types of social incident physical frailty. A 10-year prospective cohort data National Institute for Longevity Sciences – Longitudinal Study Aging (NILS-LSA) database, 2000 2012 on adults aged ≥65 years were analyzed excluding those at baseline,...