A5079435985- Osteoarthritis Treatment and Mechanisms
- Scoliosis diagnosis and treatment
- Total Knee Arthroplasty Outcomes
- Nutrition and Health in Aging
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Body Composition Measurement Techniques
- Frailty in Older Adults
- Sports injuries and prevention
- Musculoskeletal pain and rehabilitation
- Proteoglycans and glycosaminoglycans research
- Shoulder and Clavicle Injuries
- Lower Extremity Biomechanics and Pathologies
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Orthopedic Surgery and Rehabilitation
- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- MicroRNA in disease regulation
- Tendon Structure and Treatment
- Muscle Physiology and Disorders
- Nerve Injury and Rehabilitation
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Connective tissue disorders research
Nagoya University
2014-2025
Nagoya City University
2021
East Carolina University
2014-2019
Subharti Medical College
2004
Abstract Introduction Increased expression of aggrecanase-1 (ADAMTS-4) has emerged as an important factor in osteoarthritis (OA) and other joint diseases. This study aimed to determine whether the ADAMTS-4 human chondrocytes is regulated by miRNA. Methods MiRNA targets were identified using bioinformatics. Chondrocytes isolated from knee cartilage treated with interleukin-1 beta (IL-1β). Gene was quantified TaqMan assays protein production determined immunoblotting. Luciferase reporter assay...
Abstract Background Vitamin D is an essential nutrient in musculoskeletal function; however, its relationship to sarcopenia remains ambiguous, and the mechanisms targets of vitamin activity have not been elucidated. This study aimed clarify role mature skeletal muscle with sarcopenia. Methods epidemiological included 1653 community residents who participated both fifth seventh waves National Institute for Longevity Sciences, Longitudinal Study Aging had complete background data. Participants...
Abstract Background For the diagnosis of Sarcopenia, European Working Group on Sarcopenia in Older People (EWGSOP) revised algorisms 2019, where they added computed tomography (CT) as an assessment tool not only for quantity but also quality research purpose. However, evidence clinical appreciation CT has been lacking. Therefore, we investigated correlation between and various motor function tests to assess utility a potential diagnostic sarcopenia. Methods In total, 214 patients who were...
Objective: A recent report identified the small molecule kartogenin as a chondrogenic and chondroprotective agent. Since changes in hyaluronan metabolism occur during cartilage degeneration osteoarthritis, we began studies to determine whether there was connection between extracellular hyaluronan, CD44–hyaluronan interactions effects of on articular chondrocytes. Methods: Chondrocytes cultured monolayers, bioengineered neocartilages, or explants were treated with without stimulation by...
Hyaluronan is a critical component of articular cartilage and partially helps retain aggrecan within the extracellular matrix this tissue. During osteoarthritis, hyaluronan loss are an early sign tissue damage. However, our recent attempts to mimic with inhibitor 4-methylumbelliferone (4MU) did not exacerbate arthritis-like features in vitro models arthritis, but surprisingly, caused reverse (i.e. provided potent chondroprotection). Moreover, protective effects 4MU depend on its role as...
Diffuse idiopathic skeletal hyperostosis (DISH) is a common disease in older adults that causes extensive spinal ankylosis. However, its impact on quality of life (QOL) and locomotive syndrome (LS) remains unknown. Thus, we aimed to evaluate the DISH effect QOL LS community-dwelling middle-aged adults. Data community volunteers who attended health checkup 2018-2019 were assessed. A total 455 subjects included. Whole spine lateral radiographs obtained detect according Resnik criteria. was...
<title>Abstract</title> The purpose of this study was to determine the association between frailty and quality life (QOL) in a five-year longitudinal cohort community-dwelling middle-aged older adults how identify health-related QOL changes. This included 124 volunteers (67 women; mean 65 years at baseline) who underwent health checkups 2014 2019. status (robust, prefrail, frail), according Japanese Cardiovascular Health Study criteria, QOL, measured with SF-36 questionnaire, were...
Purpose: To identify differences between locomotive syndrome (LS) and frailty.Methods: A total of 1016 subjects (males 427, females 589, mean age 64 years) were prospectively examined in the Yakumo study. LS was defined as ≥16 on GLFS-25 questionnaire. Frailty diagnosed ≥3 unintentional weight loss, grip strength weakness, low walking speed, exhaustion, physical activity.Results: (14.4%) frailty (10.8%) more significant older, female with weaker muscle strength, lower gait severer pain,...
Purpose . The aim of this study was to describe the characteristics each locomotive syndrome (LS) risk stage, including global spine sagittal alignment, spinal degenerative changes evident on plain radiographs, low back pain (LBP), muscle strength, and physical ability in middle-aged elderly people a health checkup. Methods This included 211 healthy Japanese volunteers (89 men 122 women; mean age, 64.0 years) who underwent assessment with both radiographs Spinal Mouse. parameters thoracic...
Aim Advanced glycation end‐products (AGEs) are irreversibly and heterogeneously formed compounds during the non‐enzymatic modification of macromolecules, such as proteins. Aging lifestyle habits, high‐fat high‐protein diets, smoking, promote AGEs accumulation. This study aimed to investigate relationship between fall risk in community‐dwelling older adults. Methods cross‐sectional included patients from 2022 Yakumo Study who were evaluated for index 5‐items version, locomotive syndrome stage...
The healing mechanism of ruptured or injured tendons is poorly understood. To date, some lineage-specific factors, such as scleraxis and tenomodulin, have been reported markers tenocyte differentiation. Because few studies focused on lineage-related factors with respect to the repaired tissue tendons, aim this study was investigate their expression during tendon process.Defects were created in patellar rats, patellae harvested at 3 days 1, 2, 3, 6, 12, 20 weeks after surgery. They studied...
Recurrent patellar dislocation (RPD) is a multifactorial disease that affects young and active people. Patellar height measurements are used clinically to screen diagnose knee conditions. However, there no known studies have assessed compared the performance of indices for predicting incidence RPD, which could be recommend surgical treatment after primary dislocation. This case-control study aimed determine if index predict identify optimal method in terms its diagnostic ability...