A5060933834- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Nuclear physics research studies
- Parkinson's Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Neurological disorders and treatments
- X-ray Spectroscopy and Fluorescence Analysis
- Dysphagia Assessment and Management
- Nuclear Physics and Applications
- Quantum Chromodynamics and Particle Interactions
- Pain Mechanisms and Treatments
- Insect Utilization and Effects
- Inflammatory Myopathies and Dermatomyositis
- RNA Research and Splicing
- Aquaculture Nutrition and Growth
- Pain Management and Treatment
- Peripheral Neuropathies and Disorders
- Musculoskeletal pain and rehabilitation
- Hereditary Neurological Disorders
- Atomic and Molecular Physics
- Cardiomyopathy and Myosin Studies
- Mitochondrial Function and Pathology
- Ion-surface interactions and analysis
- Particle physics theoretical and experimental studies
Nagoya University
2016-2025
Nagoya University Hospital
2023-2024
Ehime University
2018-2023
Nihon University
2023
Jichi Medical University
2022
Hamamatsu University School of Medicine
2022
Aichi Medical University
2022
The University of Tokyo
2007-2018
National Clinical Research
2018
Center for Clinical Research (United States)
2018
Black soldier fly (BSF) larvae and pre-pupae could be satisfactorily raised on household organic waste used as poultry feed, offering a potential sustainable way to recycle untapped resources of waste. The present study was conducted determine if whole (non-defatted) BSF experimental substitute soybean meal oil ingredients for laying hen diets. While no significant differences in feed intake the egg-laying rate hens were observed throughout experiment, egg weight eggshell thickness greater...
Yellow mealworm (Tenebrio molitor) larvae are a potential alternative animal protein source for sustainable aquaculture. However, reports on the successful complete substitution of fish meal with yellow in an aquaculture diet have been limited. In this study, we conducted feeding trial red seabream (Pagrus major) being fed diets partial or replacement defatted hexane–ethanol solution. Feed intake increased accordance inclusion, and including 65% (complete meal) showed significant growth...
This study aimed to identify disease-related autoantibodies in the serum of patients with immune-mediated neuropathies including chronic inflammatory demyelinating polyneuropathy (CIDP) and investigate clinical characteristics these antibodies.
<h3>Objective:</h3> This study aimed to explore the reliability and validity of tongue pressure measurement as a quantitative evaluation swallowing function in patients with spinal bulbar muscular atrophy (SBMA). <h3>Methods:</h3> enrolled 47 genetically confirmed SBMA 38 age- sex-matched healthy controls. In both groups we measured using an intraoral probe assessed questionnaires that evaluated functions. We then analyzed relationship between pressure, functional scales, muscle weakness...
Spinal and bulbar muscular atrophy is an adult-onset, hereditary motor neuron disease caused by the expansion of a trinucleotide CAG repeat within gene encoding androgen receptor.To date, several agents have been shown to prevent or slow progression in animal models this disease.For translational research these agents, it necessary perform detailed analysis natural history with quantitative outcome measures establish sensitive validated disease-specific endpoints clinical trials.To end, we...
TAR DNA-binding protein 43 kDa (TDP-43), encoded by TARDBP, is an RNA-binding protein, the nuclear depletion of which histopathological hallmark amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting both upper and lower motor neurons. Besides symptoms, patients with ALS often develop nonneuronal signs including glucose intolerance, but underlying pathomechanism still controversial, i.e., whether it impaired insulin secretion and/or resistance. Here, we showed that...
Abstract Background Contamination of blood cultures can result in unnecessary testing and the unwarranted use antimicrobials.Quality control is essential to prevent these outcomes, with contamination rate serving as a key quality indicator. Various criteria exist for assessing prevalence. While enable independent computation rates by laboratory, they differ significantly from clinician judgments. But recent advancements, such improved culture bottles, new disinfectants, mass spectrometers,...
Progressive cognitive decline spanning across decades is characteristic of Alzheimer's disease (AD). Various predictive models have been designed to realize its early onset and study the long-term trajectories test scores populations interest. Research efforts geared towards superimposing patients' with trajectory denoting gradual decline, while considering heterogeneity AD. Multiple representing assessment for developed based on various parameters, highlighting importance classifying...
<title>Abstract</title> The purpose of this study was to determine the association between frailty and quality life (QOL) in a five-year longitudinal cohort community-dwelling middle-aged older adults how identify health-related QOL changes. This included 124 volunteers (67 women; mean 65 years at baseline) who underwent health checkups 2014 2019. status (robust, prefrail, frail), according Japanese Cardiovascular Health Study criteria, QOL, measured with SF-36 questionnaire, were...
The $g$ factor of the (${{h}_{\frac{9}{2}}}^{2}$) ${8}^{+}$ state $^{210}\mathrm{Po}$ has been determined to be 0.911 \ifmmode\pm\else\textpm\fi{} 0.010 by pulsed generation aligned isomeric in reaction $^{208}\mathrm{Pb}(\ensuremath{\alpha}, 2n)$. This agrees within 1% with that ${h}_{\frac{9}{2}}$ ground $^{209}\mathrm{Bi}$, indicating proton carries same renormalized anomalous magnetic moment both $^{209}\mathrm{Bi}$ and $^{210}\mathrm{Po}$.
<h3>Objective:</h3> The aim of this study was to clarify myocardial involvement and its clinical implications in subjects with spinal bulbar muscular atrophy (SBMA), a neuromuscular disease affecting both neuronal nonneuronal tissues. <h3>Methods:</h3> Two independent cardiologists evaluated ECGs from total 144 consecutive SBMA. We performed immunohistochemical, immunoblot, quantitative real-time PCR analyses autopsied myocardium. <h3>Results:</h3> Abnormal were detected 70 (48.6%) subjects....
<h3>Objective</h3> To evaluate the prognosis and progression of spinal bulbar muscular atrophy (SBMA), a rare X-linked motor neuron disorder caused by trinucleotide repeat expansion in <i>AR</i> (androgen receptor) gene, after long-term androgen suppression with leuprorelin acetate treatment. <h3>Methods</h3> In present natural history-controlled study, 36 patients SBMA treated for up to 84 months (leuprorelin acetate-treated group; LT group) 29 no specific treatment (non-treated NT were...
The aim of this study was to explore the pathomechanism underlying reduction serum creatinine (Cr) concentrations in spinal and bulbar muscular atrophy (SBMA). We evaluated blood chemistries, motor function, muscle mass measured by dual-energy X-ray absorptiometry male subjects with SBMA (n = 65), amyotrophic lateral sclerosis (ALS; n 27), healthy controls 25). also examined intramuscular creatine, a precursor Cr, as well protein mRNA expression levels creatine transporter (SLC6A8) autopsy...
While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various mutations known to facilitate aggregation, but how the nonmutated tau, which most cases with PSP share, increases its propensity aggregate neurons and glial cells has remained elusive. Here, we identified genetic variations protein abundance filamin-A brains without mutations. We provided vivo biochemical...
GNE myopathy is an ultra-rare muscle disease characterized by a reduction in the synthesis of sialic acid derived from pathogenic variants gene. No treatment has been established so far.We evaluated safety and efficacy oral supplementation aceneuramic patients with myopathy.This multicenter, placebo-controlled, double-blind study comprised genetically confirmed Japan who were randomly assigned into groups acid-extended release (SA-ER) tablets (6 g/day for 48 weeks) or placebo (4:1). The...
Abstract The clinical presentation of corticobasal degeneration is diverse, while the background pathology syndrome also heterogeneous. Therefore, predicting pathological extremely difficult. Herein, we investigated findings and course in patients with pathologically, genetically biochemically verified to determine suggestive disorder. Thirty-two were identified as having degeneration. median intervals from initial symptoms onset key milestones follows: gait disturbance, 0.0 year;...
Abstract Here, we investigated the expression of claudin family tight junction transmembrane proteins in developing mouse submandibular gland. Data obtained by reverse transcriptase‐polymerase chain reaction, Western blot, and immunofluorescence microscopy showed localization claudin‐3 to ‐8, ‐10, ‐11 at epithelial junctions. Examination glands taken from embryonic day (E) 14, E16, newborn mice revealed differential patterns these claudins epithelium. Claudin‐3, ‐5, ‐7 were expressed all...
Objective To identify a candidate biomarker reflecting biological changes during the preclinical progression of spinal and bulbar muscular atrophy (SBMA). Methods We analyzed longitudinal in biochemical parameters obtained health examinations before after diagnosis SBMA. estimated trajectories clinical markers across years from onset weakness using linear mixed models compared these with those for male healthy controls patients amyotrophic lateral sclerosis (ALS) Parkinson disease (PD)....