A5073613944- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neurological and metabolic disorders
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Neurogenetic and Muscular Disorders Research
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Neurological disorders and treatments
- Tuberculosis Research and Epidemiology
- EEG and Brain-Computer Interfaces
- Acute Ischemic Stroke Management
- Diabetes Treatment and Management
- Mycobacterium research and diagnosis
- Ophthalmology and Eye Disorders
- Pancreatic function and diabetes
- Cerebral Venous Sinus Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Prion Diseases and Protein Misfolding
- Down syndrome and intellectual disability research
- Liver Diseases and Immunity
Nagoya University
2015-2024
University of Bonn
2022-2024
Kameda Medical Center
2011-2021
Murayama Medical Center
2018-2019
Nagoya University Hospital
2017
National Epilepsy Center
2013-2015
Tokushima University
2008
Neuronal intranuclear inclusion disease (NIID) is a slowly progressive neurodegenerative characterized by eosinophilic hyaline inclusions in the central and peripheral nervous system, also visceral organs. NIID has been considered to be heterogeneous because of highly variable clinical manifestations, ante-mortem diagnosis difficult. However, since we reported usefulness skin biopsy for NIID, number diagnoses increased, particular adult-onset NIID. In this study, studied 57 cases described...
Cytoplasmic aggregation of TDP-43 in neurons is a pathological feature common to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). We demonstrate that the IκB kinase (IKK) complex promotes degradation cytoplasmic through proteasomes. While IKKβ major factor degradation, IKKα acts as cofactor, NEMO functions scaffold for recruitment IKK complex. Furthermore, we identified IKKβ-induced phosphorylation sites found at Thr8 Ser92 important reduction by IKK. was...
TAR DNA-binding protein 43 kDa (TDP-43), encoded by TARDBP, is an RNA-binding protein, the nuclear depletion of which histopathological hallmark amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting both upper and lower motor neurons. Besides symptoms, patients with ALS often develop nonneuronal signs including glucose intolerance, but underlying pathomechanism still controversial, i.e., whether it impaired insulin secretion and/or resistance. Here, we showed that...
Abstract Acute brain slices represent a workhorse model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue damage, it is unclear how microglia, main immune cells and damage sensors of CNS react this injury shape neuronal activity ex vivo. To end, we investigated microglial phenotypes contribution network organization functioning in acute slices. We reveal time-dependent phenotype changes influenced by...
Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. Here, we describe Na+ channel-dependent mechanism altered hippocampal dendritic integration, degraded place coding and in spatial memory. Two-photon glutamate uncaging experiments revealed marked increase the fraction first-order CA1 pyramidal cell dendrites capable generating spikes kainate model chronic epilepsy. Moreover, epileptic mice were generated with lower...
Neuronal intranuclear inclusion disease (NIID) is an uncommon progressive neurodegenerative disorder. Adult-onset NIID can result in prominent dementia. We herein describe the case of a 74-year-old man who presented with dementia, cerebellar ataxia, neuropathy, and autonomic dysfunction. Diffusion-weighted imaging showed hyperintensity corticomedullary junction. Fluid-attenuated inversion recovery images frontal-dominant white matter hyperintensity. was diagnosed from presence inclusions...
An otherwise healthy 44-year-old woman exhibited isolated unilateral oculomotor nerve palsy accompanied by an influenza A infection. intra-orbital MRI scan revealed that her right third intracranial was enlarged and enhanced. She recovered completely during the first month after treatment with oseltamivir phosphate. Although disorders result from infections are most frequently reported in children, it is noteworthy can also cause focal inflammation ophthalmoparesis adults. These be diagnosed...
ABSTRACT Aims : To retrospectively evaluate the pharmacological profiles of antiepileptic drugs (AEDs) in epilepsy patients during haemodialysis using therapeutic drug monitoring data. Methods The serum concentration AEDs was collected before and after haemodialysis, clearance rate concentration‐to‐dose ratio were calculated as parameters. Results Thirty‐six enrolled study (25 males, 11 females; age: 65.3 ± 14.8 years). In 24 36 patients, associated with cerebrovascular disorders, diabetes...
We describe a woman with 13‐year history of postural instability, vertical gaze palsy and dopa‐responsive parkinsonism ‐ clinical profile that corresponds to progressive supranuclear (PSP) Parkinson's disease (PD). The patient died at the age 82 years. Neuropathological features included neuronal loss gliosis in substantia nigra, locus ceruleus, dorsal motor nucleus vagus, thoracic intermediolateral basalis Meynert, addition typical pathology PSP. Immunohistochemical studies demonstrated...
Two false-positive tuberculosis (TB) cases in Yamagata Prefecture, Japan, 2016.To report the effectiveness of comparative genomics Mycobacterium for identification cross-contamination cases.Case laboratory cross-contamination.Beginning with detection an identical genotype two M. strains using variable number tandem repeat typing, we suspected specimens collected a mycobacteriology based on epidemiological investigations. This suspicion was confirmed and strain from epidemiologically...
We report a clinical case of the MV2K + C subtype sporadic reutzfeldt‐ J akob disease ( sCJD ). The patient was 72‐year‐old woman who exhibited progressive dementia over course 22 months. Diffusion‐weighted MRI during this period showed abnormal hyperintensity in cerebral cortex early stage. similar to that previously reported patients with or . However, histopathological examination revealed unique features: severe extensive spongiform changes perivacuolar deposits cerebrum and basal...
Abstract Angioinvasive aspergillus can lead to acute infarction. A 74‐year old man complained about mild weakness of the left limbs; based on diffusion‐weighted magnetic resonance imaging, he was diagnosed with infarction in right caudate and anterior limb internal capsule. After admission, had a fever disturbance consciousness. Elevated serum β‐D‐glucan, elevated galactomannan antigen titers cerebrospinal fluid histopathological analysis biopsy specimen sphenoid sinus enabled diagnosis...
Abstract Progressive multifocal leukoencephalopathy occurs almost exclusively in immunosuppressed individuals. Mirtazapine, a 5‐hydroxytryptamine‐2A antagonist, has been used empirically against progressive leukoencephalopathy. A 60‐year‐old man who was diagnosed with sarcoidosis at 20 years‐of‐age and had not taken immunosuppressive therapies developed dysarthria, left hemiparesis dressing apraxia. Cranial ?uid‐attenuated inversion‐recovery magnetic resonance imaging showed hyperintense...
Abstract Acute brain slices represent a “workhorse” model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue injury, it is unclear how microglia, main immune cells and damage sensors of CNS shape integrity ex vivo . To this end, we have studied mechanisms microglial phenotype changes contribution neuronal network organisation functioning in acute slices. Using novel ATP- reporter mouse line microglia...