A5045453988- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
HUN-REN Institute of Experimental Medicine
2021-2024
Microglia, the resident immune cells of brain, play important roles during development. Although bi-directional communication between microglia and neuronal progenitors or immature neurons has been demonstrated, main sites interaction underlying mechanisms remain elusive. By using advanced methods, here we provide evidence that microglial processes form specialized contacts with cell bodies developing throughout embryonic, early postnatal, adult neurogenesis. These developmental are highly...
Abstract Acute brain slices represent a workhorse model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue damage, it is unclear how microglia, main immune cells and damage sensors of CNS react this injury shape neuronal activity ex vivo. To end, we investigated microglial phenotypes contribution network organization functioning in acute slices. We reveal time-dependent phenotype changes influenced by...
Abstract Acute brain slices represent a “workhorse” model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue injury, it is unclear how microglia, main immune cells and damage sensors of CNS shape integrity ex vivo . To this end, we have studied mechanisms microglial phenotype changes contribution neuronal network organisation functioning in acute slices. Using novel ATP- reporter mouse line microglia...
Summary Microglia are the resident immune cells of brain with multiple homeostatic and regulatory roles. Emerging evidence also highlights fundamental transformative role microglia in development. While tightly controlled, bi-directional communication between neuronal progenitors or immature neurons has been postulated, main sites interaction underlying mechanisms remain elusive. By using correlated light electron microscopy together super-resolution imaging, here we provide that microglial...