A5006260961- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Photoreceptor and optogenetics research
- Immune cells in cancer
- Neural dynamics and brain function
- Immune Response and Inflammation
- Molecular Communication and Nanonetworks
- Memory and Neural Mechanisms
- Vagus Nerve Stimulation Research
Semmelweis University
2021-2024
HUN-REN Institute of Experimental Medicine
2021-2024
The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, main inflammatory cells brain, has remained unclear date. Therefore, we generated a novel transgenic mouse line which microglial was deleted. We show that shapes both baseline and reactive microglia morphology, process recruitment site injury, adaptation changes cellular volume cell-autonomous manner via regulating membrane conductance. In addition, deficiency results...
GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset these contains somatostatin (SOM); cells play crucial roles in neuroplasticity, learning, memory many brain areas including hippocampus, are implicated several neuropsychiatric diseases neurodegenerative disorders. Two main types SOM-containing area CA1 hippocampus oriens-lacunosum-moleculare (OLM) hippocampo-septal (HS) cells. These cell show similarities their soma-dendritic...
Abstract Acute brain slices represent a workhorse model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue damage, it is unclear how microglia, main immune cells and damage sensors of CNS react this injury shape neuronal activity ex vivo. To end, we investigated microglial phenotypes contribution network organization functioning in acute slices. We reveal time-dependent phenotype changes influenced by...
Abstract Acute brain slices represent a “workhorse” model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue injury, it is unclear how microglia, main immune cells and damage sensors of CNS shape integrity ex vivo . To this end, we have studied mechanisms microglial phenotype changes contribution neuronal network organisation functioning in acute slices. Using novel ATP- reporter mouse line microglia...
Abstract The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, main inflammatory cells brain, has remained unclear date. Therefore, we generated a novel transgenic mouse line which microglial was deleted. We show that shapes both baseline and reactive microglia morphology, process recruitment site injury, adaptation osmotic stress cell-autonomous manner via regulating membrane potential chloride fluxes. In addition,...
ABSTRACT GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset these contains somatostatin (SOM); cells play crucial roles in neuroplasticity, learning memory many brain areas including hippocampus, are implicated several neuropsychiatric diseases neurodegenerative disorders. Two main types SOM-containing area CA1 hippocampus oriens-lacunosum-moleculare (OLM) hippocampo-septal (HS) cells. These cell show similarities their...