A5059640482- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Retinoids in leukemia and cellular processes
- Cholesterol and Lipid Metabolism
- interferon and immune responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Morinda citrifolia extract uses
- Adenosine and Purinergic Signaling
- Bone health and treatments
University of Debrecen
2019-2022
Yarmouk University
2018
Hashemite University
2018
The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, main inflammatory cells brain, has remained unclear date. Therefore, we generated a novel transgenic mouse line which microglial was deleted. We show that shapes both baseline and reactive microglia morphology, process recruitment site injury, adaptation changes cellular volume cell-autonomous manner via regulating membrane conductance. In addition, deficiency results...
All-trans retinoic acid (ATRA) is a derivative of vitamin A that has many important biological functions, including the modulation immune responses. ATRA actions are mediated through receptor functions as nuclear receptor, either regulating gene transcription in nucleus or modulating signal transduction cytoplasm. NLRP3 inflammasome multiprotein complex activated by huge variety stimuli, pathogen- danger-related molecules. Activation required for production IL-1β, which drives inflammatory...
Besides its well-known psychoactive effects, caffeine has a broad range of actions. It regulates several physiological mechanisms as well modulates both native and adaptive immune responses by various ways. Although is assumed to be negative regulator inflammation, the effect on secretion pro- anti-inflammatory cytokines highly controversial. Macrophages are major mediators inflammatory responses; however, subpopulations develop different effects ranging from initiation resolution...
Syk is a nonreceptor tyrosine kinase critically involved in signaling by various immunoreceptors including B-cell-receptors and activating Fc-receptors. We have previously shown that also mediates immunoreceptor-like signals required for the vitro development function of osteoclasts. However, perinatal lethality Syk–/– mice precluded analysis role vivo bone metabolism. To overcome problem, we generated with osteoclast-specific (SykΔOC) or hematopoietic (SykΔHaemo) deficiency conditional...
Anastatica hierochuntica L. (Brassicaceae) has been used in folk medicine to treat diseases related inflammation and pain. This study investigated the antinociceptive antiinflammatory effects of aqueous extract chloroform fraction A. plant possible mechanism action Swiss albino mice Wistar rats. The activity was evaluated using hot-plate, tail immersion, writhing formalin-induced paw liking tests, while carrageenan-induced edema over a period 5 h dose range 3.16 1000 mg/kg, i.p. These were...
Abstract The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, main inflammatory cells brain, has remained unclear date. Therefore, we generated a novel transgenic mouse line which microglial was deleted. We show that shapes both baseline and reactive microglia morphology, process recruitment site injury, adaptation osmotic stress cell-autonomous manner via regulating membrane potential chloride fluxes. In addition,...