A5042457135- Viral Infectious Diseases and Gene Expression in Insects
- Enzyme Catalysis and Immobilization
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- Enzyme Production and Characterization
- Ubiquitin and proteasome pathways
- Plant-Microbe Interactions and Immunity
- Immune Cell Function and Interaction
- Plant Reproductive Biology
- Animal Genetics and Reproduction
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Pineapple and bromelain studies
- Food and Agricultural Sciences
- Genetic Neurodegenerative Diseases
- Biopolymer Synthesis and Applications
- Biofuel production and bioconversion
- biodegradable polymer synthesis and properties
- Enzyme Structure and Function
- Diet, Metabolism, and Disease
- Muscle Physiology and Disorders
- Probiotics and Fermented Foods
- Plant Disease Resistance and Genetics
- Papaya Research and Applications
- Retinoids in leukemia and cellular processes
Zewail City of Science and Technology
2020-2021
University of Debrecen
2019-2020
University of Technology Malaysia
2017
All-trans retinoic acid (ATRA) is a derivative of vitamin A that has many important biological functions, including the modulation immune responses. ATRA actions are mediated through receptor functions as nuclear receptor, either regulating gene transcription in nucleus or modulating signal transduction cytoplasm. NLRP3 inflammasome multiprotein complex activated by huge variety stimuli, pathogen- danger-related molecules. Activation required for production IL-1β, which drives inflammatory...
Huntington's disease (HD) is an inherited neurodegenerative disorder, caused by abnormal polyglutamine (polyQ) expansion in the huntingtin protein (Htt). Mitochondrial dysfunction and impairment of ubiquitin-proteasome system (UPS) are hallmarks HD neurons. The extraneural manifestations still unclear. We investigated crosstalk between mitochondria proteolytic function skin fibroblasts from juvenile patients. found reduced mitosis, increased cell size, elevated ROS mitochondrial membrane...
The Blm10/PA200 family of proteasome activators modulates the peptidase activity core particle (20S CP). They participate in opening 20S CP gate, thus facilitating degradation unstructured proteins such as tau and Dnm1 a ubiquitin- ATP-independent manner. Furthermore, PA200 also participates acetylated histones. In our study, we use combination yeast human cell systems to investigate role N-terminal Huntingtin fragments (N-Htt). We demonstrate that binds N-Htt. loss Blm10 or cells results...
The conserved Blm10/PA200 activators bind to the proteasome core and facilitate peptide protein turnover. proteins enhance peptidase activity accelerate degradation of unstructured substrates. Our knowledge about exact role PA200 in diseased cells, however, is still limited. Here, we show that stable knockdown leads a significantly elevated number cells S phase after treatment with ATP synthase inhibitor, oligomycin. However, following exposure complex I inhibitor rotenone, more...
ABSTRACT Understanding how promoters work in non-host cells is complex. Nonetheless, understanding this process crucial while performing gene expression modulation studies. In study, inhibitory regions the 5’ end of OpIE2 insect viral promoter were found to be blocking activity CMV mammalian cells. This finding was reached constructing a shuttle vector with and tandem arrangement achieve both cells, respectively. cloned downstream upstream EGFP reporter gene. After introducing constructed...