A5049736891- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Neuropathies and Disorders
- Neurogenetic and Muscular Disorders Research
- Cerebral Venous Sinus Thrombosis
- Multiple Sclerosis Research Studies
- Spinal Dysraphism and Malformations
- Infectious Encephalopathies and Encephalitis
- Alzheimer's disease research and treatments
- Ophthalmology and Eye Disorders
- Advanced Neuroimaging Techniques and Applications
- Neurological diseases and metabolism
- Spondyloarthritis Studies and Treatments
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cerebrospinal fluid and hydrocephalus
- Chronic Kidney Disease and Diabetes
- MRI in cancer diagnosis
- Retinal and Optic Conditions
- Cervical and Thoracic Myelopathy
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Neurodegenerative Diseases
Nagoya University
2010-2024
Komaki City Hospital
2015-2024
Nagoya University Hospital
2015
Chubu Rosai Hospital
2013
We investigated 17 patients with sporadic amyotrophic lateral sclerosis (ALS) using voxel-based morphometry (VBM) and analysis of diffusion tensor images (DTI) at baseline after a six-month follow-up. Compared healthy controls, ALS showed only minimal white matter volume decreases in the inferior frontal gyrus but marked gray several regions, especially bilateral paracentral lobule premotor cortex. DTI revealed reduced fractional anisotropy corticospinal tracts, insula, ventrolateral cortex,...
Our aim was to evaluate the location and extent of white matter involvement in patients with amyotrophic lateral sclerosis (ALS) using diffusion-tensor magnetic resonance imaging (DTI). We obtained fractional anisotropy (FA) values from internal capsule various regions 46 sporadic ALS 19 control subjects. In patients, FA capsule, frontal matter, genu splenium corpus callosum (p<0.001), parietal temporal lobe posterior cingulum (p<0.05) were significantly lower than controls. (p<0.001)....
<h3>Purpose</h3> Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, clinical course and progression ALS varies widely. Brain detected using structural MRI could reflect disease progression. <h3>Subjects methods</h3> On study registration, 3-Tesla volumetric diffusion tensor imaging scans were obtained at baseline in 38 healthy controls 67 patients sporadic ALS. Patients had Lateral...
We investigated common structural and network changes across the sporadic amyotrophic lateral sclerosis (ALS)-frontotemporal dementia (FTD) continuum. Based on cluster analysis using frontotemporal assessment battery, 51 patients with ALS were subdivided into three groups: 25 cognitive deficiency (ALS-CD); seven who satisfied FTD criteria (ALS-FTD), 19 normal function (ALS-NC). Compared controls, gray matter images from ALS-FTD showed atrophic in following order of severity: caudate head,...
We investigated the factors influencing inpatient convalescent rehabilitation outcomes in patients with ischemic stroke, particularly severity of leukoaraiosis on magnetic resonance imaging.Participants included 520 stroke (317 men and 203 women; mean age, 72.8±8.4 years) who were transferred from acute care hospitals for rehabilitation. Ischemic subtypes lacunar infarction (n=41), atherothrombosis (n=223), artery-to-artery embolism (n=67), cardiogenic (n=97), undetermined (n=76),...
Albuminuria, a marker of chronic kidney disease, is associated with an increased risk incident stroke and unfavorable long-term outcomes. However, the association albuminuria short-term outcomes change in infarct volume patients acute small subcortical infarction remains unknown.We retrospectively reviewed 85 consecutive infarcts lenticulostriate artery territory who were admitted to our center within 24 hours symptom onset underwent serial diffusion-weighted imaging (DWI). Albuminuria was...
We herein report a 72-year-old woman with rheumatoid vasculitis who exhibited depressed level of consciousness after receiving the first dose Pfizer-BioNTech mRNA BNT162b COVID-19 vaccine and was diagnosed meningoencephalitis. Although there no confirmatory examination, diagnosis based on magnetic resonance imaging (MRI) findings etiological assessments, including microbiological autoimmune investigations. Both intravenous steroid pulse gammaglobulin therapies alleviated patient's symptoms,...
A 21-year-old man had sudden-onset right hemiplegia and aphasia with respiratory infection. chest X-ray disclosed consolidation in both lungs magnetic resonance imaging showed an embolism the left middle cerebral artery. pelvic computed tomography scan revealed deep venous thrombus femoral veins. Patent foramen ovale was detected by transesophageal echocardiogram. Antibodies to M. pneumoniae were highly elevated, hypercoagulability subsequently detected. This case suggests that possible...
An otherwise healthy 44-year-old woman exhibited isolated unilateral oculomotor nerve palsy accompanied by an influenza A infection. intra-orbital MRI scan revealed that her right third intracranial was enlarged and enhanced. She recovered completely during the first month after treatment with oseltamivir phosphate. Although disorders result from infections are most frequently reported in children, it is noteworthy can also cause focal inflammation ophthalmoparesis adults. These be diagnosed...
Cilostazol is a phosphodiesterase III-inhibiting antiplatelet agent that often used to prevent stroke and peripheral artery disease, its administration has shown significant improvements for cognitive impairment. We investigate the potential of cilostazol reducing or restoring decline during convalescent rehabilitation in patients with non-cardioembolic ischemic stroke. The study sample included 371 consecutive lacunar (n = 44) atherothrombosis 327) subtypes (224 men 147 women; mean age,...
Voxel-based analysis (VBA) of diffusion tensor images (DTI) and voxel-based morphometry (VBM) in patients with multiple sclerosis (MS) can sensitively detect occult tissue damage that underlies pathological changes the brain. In present study, both at start fingolimod post-four months clinical remission, we assessed four MS who were evaluated VBA DTI, VBM, fluid-attenuated inversion recovery (FLAIR). DTI for all showed widespread areas increased mean diffusivity (MD) decreased fractional...
We investigated the associations among neurological severity, activities of daily living (ADLs), and clinical factors in patients with ischemic stroke convalescent rehabilitation outcome. The study sample included 723 (484 men 239 women; mean age, 73.2 ± 8.5 years) for inpatient rehabilitation. National Institutes Health Stroke Scale (NIHSS) was used to measure Functional Independence Measure (FIM) assess ADLs at discharge. Leukoaraiosis graded based on periventricular hyperintensity (PVH)...
A 41-year-old woman was admitted due to a sudden-onset severe headache, left hemiparesis and dysarthria. Diffusion-weighted magnetic resonance imaging showed an acute infarct in the bilateral pons, angiography revealed basilar artery (BA) occlusion resulting from dissection of right vertebral (VA). She treated with intravenous recombinant tissue plasminogen activator (rt-PA) 110 minutes after symptom onset. Subsequently, brain performed along mechanical thrombolysis using Trevo ProVue...
To elucidate the usefulness of plasma B-type natriuretic peptide (BNP) values for evaluating adverse effects pergolide or cabergoline on cardiovalvulopathy in patients with Parkinson disease.Twenty-five treated (ergot group) and 25 never ergot derivatives (non-ergot were enrolled. Plasma BNP detailed echocardiography evaluated. Thirty age- gender-matched controls similarly evaluated.Patients regurgitation more than grade 3 frequent group non-ergot as well control groups (24%, 0%, 3%, p =...
A 69-year-old woman was admitted to our hospital with a fever, dizziness, and headache caused by Neisseria meningitidis. After ceftriaxone administered, she suddenly developed bilateral oculomotor nerve palsy. Intra-orbital magnetic resonance imaging using appropriate sequences revealed that her third intracranial nerves were enlarged enhanced. She achieved complete recovery two months after additional short-term treatment intravenous immunoglobulin methylprednisolone. Although disorders...
当院における回復期脳梗塞リハビリテーションの成績について検討した．対象は回復期入院脳梗塞患者連続178 例で，入退院時の脳卒中重症度(NIHSS)，各種ADL評価(mRS·Barthel Index·FIM)とその改善度(FIM-g·FIM-e)を検討した．全例脳MRI·MRAによる脳白質病変・頭蓋内主幹動脈の評価を行った．NIHSSはラクナ梗塞群で入院時(p=0.047)，退院時(p=0.045)共に有意に軽症であった他は，脳梗塞群間で有意差は認めなかった．FIM-eはラクナ梗塞群・アテローム血栓性梗塞群に比べ，動脈原性塞栓群で有意に低下していた(p<0.05)．この群は脳MRAで高率に動脈狭窄・閉塞像を認めた上で白質病変が強い傾向にあり，重回帰分析で白質病変の程度が退院時FIMに強く影響を与えていた．脳白質病変が回復期脳梗塞リハビリテーションの成績に影響を与える可能性が示唆された．