A5011952370- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Frailty in Older Adults
- Pharmaceutical Practices and Patient Outcomes
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Health, Environment, Cognitive Aging
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Management and Research
- Epilepsy research and treatment
- Health disparities and outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Aging and Gerontology Research
- Maternal Mental Health During Pregnancy and Postpartum
- Chemotherapy-induced cardiotoxicity and mitigation
- Sexual function and dysfunction studies
- Physical Activity and Health
- Health and Medical Research Impacts
- Medical Coding and Health Information
- Hormonal and reproductive studies
- Nutritional Studies and Diet
- Pain Management and Placebo Effect
National Yang Ming Chiao Tung University
2022-2024
National Center for Geriatrics and Gerontology
2024
National Taiwan University
2018-2023
Memorial Hospital of South Bend
2008
Taoyuan Chang Gung Memorial Hospital
2007
Integrating primary prevention into care pathways for older adults is a core strategy of healthy ageing, but evidence remains limited. We aimed to determine whether incorporating multidomain intervention health could improve standard value-based outcomes and quality life.For this Taiwan Integrated Geriatric Care (TIGER) study, pragmatic randomised controlled trial, we recruited community-dwelling outpatients aged 65 years or with at least three chronic medical conditions. excluded people...
Abstract Background Frailty often coexists with heart failure (HF), which significantly aggravates the clinical outcomes of older adults. However, studies investigating interplay between frailty and HF in adults are scarce. We aimed to assess prevalence using cumulative deficit approach evaluate impacts on health utilization, use HF‐related medications adverse (all‐cause mortality, all‐cause readmissions readmissions) among patients. Methods A total 38 843 newly admitted patients were...
Components of physical frailty cluster into subtypes, but it remains unknown how these might be associated with age-related functional declines and multimorbidities. This study aims to investigated associations subtypes multimorbidity in a 10 year longitudinal cohort survey.Complementary used group-based multitrajectory modelling verify whether discovered Taiwan are presented another aging cohort, then cognitive decline multimorbidity. Participants aged ≥50 years were recruited from the...
This study aims to develop and validate an integrative intrinsic capacity (IC) scoring system, investigate its associations with a wide spectrum of biomarkers explore the predictive value IC score on 4-year mortality among community dwelling people aged 50 years older.We included 839 adults ≥50 from Social Environment Biomarkers Aging Study (SEBAS) randomly divided them into derivation validation cohorts system. The multivariate logistic regression model was used weight each subdomain...
Our aim was to explore the patterns of intrinsic capacity (IC) impairments among community-dwelling older adults and associations these different with excessive polypharmacy, potentially inappropriate medications, adverse drug reactions in a nationwide population-based study. A cross-sectional study included from Taiwan Integrated Care for Older People (ICOPE) program 2020. The subjects comprised 38,308 aged 65 years who participated ICOPE Step 1 screening assessed six domains IC following...
Abstract Aims Frailty substantially increased the risk of adverse clinical outcomes, which was also critical in diabetes management. This study aimed to investigate interrelationships between age onset, frailty, anti-diabetic medications and outcomes people with mellitus (DM). Methods A total 123,172 aged 40 years older who were newly diagnosed DM identified categorised into four frailty subgroups (robust, mild, moderate severe) based on multimorbidity index (mFI). Cox proportional hazards...
Background Using big data and the theory of cumulative deficits to develop multimorbidity frailty index (mFI) has become a widely accepted approach in public health care services. However, constructing mFI using most critical determinants stratifying different risk groups with dose-response relationships remain major challenges clinical practice. Objective This study aimed by machine learning methods that select variables based on optimal fitness model. In addition, we further establish 4...
Background Dementia development is a complex process in which the occurrence and sequential relationships of different diseases or conditions may construct specific patterns leading to incident dementia. Objective This study aimed identify disease symptom clusters their sequences prior dementia using novel approach incorporating machine learning methods. Methods Using Taiwan’s National Health Insurance Research Database, data from 15,700 older people with nondementia controls matched on age,...
Conflicting data of the potential association between proton pump inhibitors ( PPI s) and risk dementia have been reported. This study aimed to examine subsequent incident in older adults by categorizing subjects into different trajectories longitudinal use. A group‐based trajectory modeling was used identify distinct groups with regard use over 3 years further a 5‐year follow‐up. Among 10,533 who initiated s, three were identified: short‐term n = 7,406, 70.3%), intermittent 1,528, 14.5%),...
Infectious diseases are the leading cause of deaths in adults aged 65 years or older. Studies adverse infection outcomes have been limited to specific infections and acute episodes not investigated longitudinal trends cumulative infections. We aimed identify distinct trajectories older assess their corresponding risk all-cause mortality.In this retrospective cohort study, we included people who were admitted hospital between Jan 1 Dec 31, 2011, with one following infections: urinary tract,...
Abstract Large-scale epidemiological data on cryptococcosis other than cryptococcal meningitis (CM), human immunodeficiency virus (HIV)- or solid organ transplantation (SOT)-associated are limited. This study investigated the disease burden of in Taiwan over 14 years. Incident episodes cryptococcosis, comorbidities, treatment, and outcomes were captured from Taiwan's National Health Insurance Research Database Death Registry between 2002 2015. Of 6647 analyzed, crude incidence rate per 100...
Abstract Background This manuscript compares the efficacy and safety of duloxetine with placebo in Taiwanese women SUI. Methods SUI were randomly assigned to (n = 61) or 80 mg/day 60) this double-blind, 8-week, placebo-controlled study. Outcome variables included: incontinence episode frequency (IEF), Incontinence Quality Life questionnaire (I-QOL) scores, Patient Global Impression Improvement rating (PGI-I). Results Decrease IEF was significantly greater duloxetine-treated than...
The cumulative effect of multiple pharmaceutics with anticholinergic properties (i.e., burden), can serve as an indicator suboptimal prescribing in the elderly. Yet, no research is available concerning different compositions score on adverse outcomes under same burden. This population-based cohort study investigated whether combinations medications have impacts elderly using Anticholinergic Risk Scale (ARS) and Cognitive Burden (ACB) scores. We included 116,043 people aged 65 years older...
Abstract Aims The objective of this study was to estimate the nationwide annual incidence, healthcare utilization, and mortality among hospitalized heart failure (HF) patients in Taiwan. Methods results People aged 20 years or older having been newly admitted for HF between 2010 2015 were identified from Taiwan's National Health Insurance Research Database. For 124 816 with incident hospitalizations 2012, we further analysed their treatment patterns, utilizations, during index...