A5026148947- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Gut microbiota and health
- Nutrition and Health in Aging
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Frailty in Older Adults
- Nutritional Studies and Diet
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Hearing Loss and Rehabilitation
- Neurological Disorders and Treatments
- Autoimmune Neurological Disorders and Treatments
- Diabetes Treatment and Management
- Advanced Neuroimaging Techniques and Applications
- Olfactory and Sensory Function Studies
- Ophthalmology and Eye Disorders
- Nutrition, Health and Food Behavior
- Neurological and metabolic disorders
National Center for Geriatrics and Gerontology
2016-2025
Nippon Zoki (Japan)
2013-2019
Kawasaki Medical School
2012-2018
Hyogo Brain and Heart Center
2006-2016
Kurashiki Medical Center
2014
Kobe University
2010-2011
Hashimoto Municipal Hospital
2004-2010
Abstract Dysregulation of the gut microbiome is associated with several life-threatening conditions and thus might represent a useful target for prevention dementia. However, relationship between microbial population dementia has not yet been fully clarified. We recruited outpatients visiting our memory clinic to participate in this study. Information on patient demographics, risk factors, activities daily living was collected, cognitive function assessed using neuropsychological tests brain...
Abstract Recent studies have revealed an association between the dysregulation of gut microbiome and dementia. However, whether this is associated with mild cognitive impairment (MCI), early stage decline, in patients without dementia remains unclear. We performed a cross-sectional analysis to determine MCI. Data, including patient demographics, risk factors, function, brain imaging, were collected. The was assessed through terminal restriction fragment length polymorphism analysis....
We examined the nutritional status and its association with behavioral psychiatric symptoms of dementia (BPSD) among 741 memory clinic patients (normal cognition (NC), 152; mild cognitive impairment (MCI), 271; early-stage Alzheimer disease (AD), 318). Nutritional BPSD were assessed using Mini Assessment Short-Form (MNA-SF) Dementia Behavior Disturbance Scale (DBD), respectively. Compared to subjects NC, more MCI AD at risk malnutrition (MNA-SF, 8–11: 34.2%; MCI, 47.5%; AD, 53.8%)...
This study aimed to investigate the association between abdominal adiposity and change in cognitive function community-dwelling older adults.
To date, very little is known about the nature of sarcopenia in subjects with cognitive impairment. The aims this study were firstly to clarify prevalence at various stages impairment, and secondly examine factors related men women impairment.The 418 outpatients (normal cognition; NC: 35, amnestic mild impairment; aMCI: 40, Alzheimer disease; AD: 343) who attended Memory Clinic National Center for Geriatrics Gerontology Japan during period from October 2010 July 2014. Cognitive status,...
Abstract Dysregulation of the gut microbiome is associated with dementia. However, relationship between microbiome-associated metabolites and dementia has yet to be identified. Outpatients visiting a memory clinic in Japan enrolled this cross-sectional study; 107 subjects were eligible for study, 25 which had We collected demographics, activities daily living, risk factors, cognitive function, brain imaging data. The was assessed using terminal restriction fragment length polymorphism...
Hyperglycemia is recognized as a common occurrence associated with high risk of poor outcome in ischaemic stroke patients. However, little known about the association between elevated glucose level, growth infarct volume and neurological deterioration patients without diabetes. The present study aimed to clarify this issue acute arterial occlusion.We studied 375 occlusion within 24 h onset. Diabetes was diagnosed history diabetes or HbA1c value ≥ 6.5%. Infarct measured on admission at...
Background and Purpose— It is unknown whether new-extraischemic microbleeds (new-EMBs) develop rapidly after tissue-type plasminogen activator (tPA) infusion. We hypothesized that new-EMBs may tPA infusion using T2*-weighted MRI (T2*) investigated the frequency clinical factors associated with new-EMBs. Methods— Patients acute stroke within 3 hours of onset who were treated studied prospectively. T2* was performed before 24 therapy. Independent development examined multivariate logistic...
The mechanism of progressive neurological deficit (PND) in patients with ischemic stroke remains unclear. aim this study was to clarify whether arterial stiffness, a marker vascular endothelial impairment and arteriosclerosis, is associated PND acute deep subcortical infarction.We evaluated 156 consecutive first-ever infarction. defined as an increment ≥2 points the National Institute Health Stroke Scale score or increase ≥1 point limb weakness within 7 days onset. Patients were assessed for...
<i>Background:</i> White matter hyperintensities (WMHs) are a risk factor for stroke. Their etiology is considered to be cerebral microvascular abnormality. However, the association between WMHs and arteriosclerosis not yet clear. The aim of this hospital-based cohort study was identify arteriosclerotic characteristics associated with WMHs. <i>Methods:</i> We cross-sectionally included 240 consecutive patients no history measured brachial-ankle pulse wave velocity...
Objective The aim of this hospital-based cohort study was to clarify the independent association between silent brain infarct (SBI) and arterial stiffness indicated by brachial-ankle pulse wave velocity (baPWV) including cutoff value for SBI. Methods We studied 240 consecutive patients (mean age 69 years) with no history stroke. assessed presence SBI, white matter hyperintensities (WMHs), risk factors. Arterial evaluated using baPWV. measured intima-media thickness common carotid artery...
Previous studies have shown associations between the gut microbiota, microbial metabolites, and cognitive decline. However, effect of dietary composition on such has not been fully investigated. The aims this study were to evaluate relationships adherence a Japanese-style diet, Furthermore, we aimed three forms Japanese diet index (JDI; conventional [JDI9], updated [JDI12], newly modified JDI) determine which would show closest with cognition microbiota.We performed cross-sectional...
We conducted a multicenter retrospective cohort study to elucidate the characteristics of intracranial hemorrhage (ICH) in patients with atrial fibrillation treated non-vitamin K antagonist oral anticoagulants (NOACs).We sent questionnaire directors 241 stroke centers Japan establish clinical NOAC-associated cerebral (CH), including hematoma size, enlargement (HE) and in-hospital mortality their institutions. undertook literature review warfarin-associated CH compared these our data....
Purpose: To examine whether Functional Independence Measure (FIM) scores on admission can predict the future care levels of patients after acute stroke. Methods: In this multicenter retrospective cohort study, we enrolled post-acute stroke and assessed subtypes, self-care abilities using FIM scores, discharge destination. Patients' were according to Long-Term Care Insurance (LTCI) system (0–5: slight impairment bedridden), national insurance plan for in Japan, at discharge. We divided into...