A5038004243- Diet and metabolism studies
- Gut microbiota and health
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Nutrition, Health and Food Behavior
- Peroxisome Proliferator-Activated Receptors
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical effects in animals
- Lipid metabolism and biosynthesis
- Cholesterol and Lipid Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Sphingolipid Metabolism and Signaling
- Tea Polyphenols and Effects
- Eicosanoids and Hypertension Pharmacology
- Alzheimer's disease research and treatments
- Phytoestrogen effects and research
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
Tohoku University
2014-2023
Research Institute for Bioscience and Biotechnology
2009-2013
The development of Alzheimer's disease (AD) biomarkers remains an unmet challenge, and new approaches that can improve current AD biomarker strategies are needed. Recent reports suggested microRNA (miRNA) profiling biological fluids has emerg
Abstract Dysregulation of the gut microbiome is associated with several life-threatening conditions and thus might represent a useful target for prevention dementia. However, relationship between microbial population dementia has not yet been fully clarified. We recruited outpatients visiting our memory clinic to participate in this study. Information on patient demographics, risk factors, activities daily living was collected, cognitive function assessed using neuropsychological tests brain...
Abstract Recent studies have revealed an association between the dysregulation of gut microbiome and dementia. However, whether this is associated with mild cognitive impairment (MCI), early stage decline, in patients without dementia remains unclear. We performed a cross-sectional analysis to determine MCI. Data, including patient demographics, risk factors, function, brain imaging, were collected. The was assessed through terminal restriction fragment length polymorphism analysis....
Ferroptosis is a form of regulated cell necrosis, as consequence Fe(II)-dependent lipid peroxidation. Although ferroptosis has been linked to cancer death, neurodegeneration and reperfusion injury, physiological roles have not elucidated date mostly due the lack appropriate methodologies. Here, we show that 4-hydroxy-2-nonenal (HNE)-modified proteins detected by HNEJ-1 mouse monoclonal antibody robust immunohistochemical technology locate in tissues combination with morphological nuclear...
Amyloid β-peptide (Aβ) is hypothesized to play a key role by oxidatively impairing the capacity of red blood cells (RBCs) deliver oxygen brain. These processes are implicated in pathogenesis Alzheimer's disease (AD). Although plasma Aβ has been investigated thoroughly, presence and distribution human RBCs still unclear. In this study, we quantitated Aβ40 Aβ42 with ELISA assays, provided evidence that significant amounts could be detected RBC levels increased aging. The On other hand,...
Abstract Dysregulation of the gut microbiome is associated with dementia. However, relationship between microbiome-associated metabolites and dementia has yet to be identified. Outpatients visiting a memory clinic in Japan enrolled this cross-sectional study; 107 subjects were eligible for study, 25 which had We collected demographics, activities daily living, risk factors, cognitive function, brain imaging data. The was assessed using terminal restriction fragment length polymorphism...
Red blood cells (RBC) of Alzheimer's disease (AD) patients are known to be in an excessively oxidized state (i.e., with a high accumulation peroxidized phospholipids (PLOOH)). Previously we confirmed vitro, vivo murine, and human studies
Sphingolipids are ubiquitous in all eukaryotic organisms. Various physiological functions of dietary sphingolipids, such as preventing colon cancer and improving the skin barrier function, have been recently reported. One common sphingolipids used a foodstuff is glucosylceramide from plant sources, which composed sphingoid bases distinct those mammals. However, fate derived plants still not understood. In this study, we investigated absorption maize rat intestine using lipid assay lymph...
It was recently shown that administration of 1-deoxynojirimycin (DNJ) extracted from mulberry suppresses an increase in postprandial blood glucose humans. These findings are interest, but other physiological functions DNJ unknown. This study examined the effects oral (1 mg/kg body weight/day) or extracts enriched (meDNJ; 100 200 mg extract/kg weight/day, equivalent to 0.53 1.06 DNJ/kg male Sprague−Dawley rats for 4 weeks. and meDNJ enhanced expression adiponectin mRNA white adipose tissue;...
The effect of 1-deoxynojirimycin, a caloric restriction mimetic, was examined in ICR mice with azoxymethane dextran sodium sulfate-induced colorectal cancer. Azoxymethane is carcinogen (10 mg/kg body weight), and 2% sulfate (w/v) used as colitis-inducing agent. Mice were separated into 5 groups: group without cancer fed normal diet (CO- group), groups (CO+ calorie-restricted (caloric diets including 0.02% 0.1% 1-deoxynojirimycin (l-1-deoxynojirimycin H-1-deoxynojirimycin groups). tumor...
A lot of Japanese people are generally known for having a healthy diet, and consume variety mushrooms daily. Many studies have reported anti-obesity effects mushrooms, but few investigated the consuming edible mushroom types together in realistic quantities. In this study, we whether supplementation with affects visceral fat accumulation gut microbiota mice. The most popular varieties Japan were lyophilized mixed according to their local production ratios. C57BL/6J mice fed normal high-fat...
In our previous study, the health benefits of 1975 Japanese diet were shown to be highest, since suppressed visceral and liver fat accumulation, hyperglycemia. addition, promoted maintenance learning memory ability a lengthened life span. However, effect has not been ascertained in humans. current with characteristics was prepared examine if this is beneficial for human health. The purpose randomized controlled trial determine effects (JD) comparison modern (MD). Subjects aged 20~29 years...
Although it has been suggested that the Japanese diet contributes to longevity of population, no study examined association between and survival time. The present investigated time.We analyzed 20-year follow-up data from a cohort 14,764 men women aged 40-79 years. At baseline survey in 1994, we collected dietary information using validated 40-item food frequency questionnaire. Adherence consisting nine components (rice, miso soup, seaweeds, pickles, green yellow vegetables, fish, tea, beef...
Previous studies have shown associations between the gut microbiota, microbial metabolites, and cognitive decline. However, effect of dietary composition on such has not been fully investigated. The aims this study were to evaluate relationships adherence a Japanese-style diet, Furthermore, we aimed three forms Japanese diet index (JDI; conventional [JDI9], updated [JDI12], newly modified JDI) determine which would show closest with cognition microbiota.We performed cross-sectional...
Recently, tocotrienol (T3), a less well-known form of vitamin E, has gained considerable attention as potent antiangiogenic agent. However, the majority E research focused on tocopherol (Toc), with some studies indicating alpha-Toc may prevent tumor angiogenesis. In this study, we aimed to clarify differences in potential between delta-T3 and alpha-Toc. We showed (2.5-5 microM) completely abolished proliferation, migration tube formation human umbilical vein endothelial cells (HUVECs),...
The presence of amyloid β-peptide (Aβ) in human blood has recently been established, and it hypothesized that Aβ readily contacts red cells (RBC) oxidatively impairs RBC functions. In this study, we conducted vitro vivo studies, which provide evidence induces oxidative injury to by binding them, causing phospholipid peroxidation diminishing endogenous carotenoids, especially xanthophylls. This type damage is likely injure the vasculature, potentially reducing oxygen delivery brain...