A5025872451- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Frailty in Older Adults
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Health and Well-being Studies
- Noise Effects and Management
- Bone health and osteoporosis research
- Vestibular and auditory disorders
- Body Composition Measurement Techniques
- Health disparities and outcomes
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
- Health and Wellbeing Research
- Alcohol Consumption and Health Effects
- Work-Family Balance Challenges
- Liver Disease Diagnosis and Treatment
- Glaucoma and retinal disorders
- Aging and Gerontology Research
- Health Systems, Economic Evaluations, Quality of Life
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Balance, Gait, and Falls Prevention
Aichi Shukutoku University
2016-2025
National Center for Geriatrics and Gerontology
2016-2025
Japan Pediatric Society
2018
National Institute of Infectious Diseases
2018
GGG (France)
2013
Nagoya University
1987-2008
Tokyo Metropolitan Institute of Gerontology
2004
Suzuki (Japan)
2004
Nippon Medical School
2004
National Hospital Organization Kyushu Cancer Center
2004
A new comprehensive longitudinal study of aging, the National Institute for Longevity Sciences, Longitudinal Study Aging (NILS-LSA) started in November 1997. The participants this will be 2, 400 residents aged 40 to 79 years who were ageand gender-stratified random samples selected from NILS area. All provided written informed consent after a detailed explanation study. They examined at NILS-LSA Examination Center every two years. Their first wave examinations finished by end March 2000....
Background Some cross-sectional studies have suggested that age, systolic blood pressure and obesity are positively related to intraocular (IOP), but few longitudinal examined this relationship. This study was carried out evaluate the association between by analyses in a large Japanese population.
The present study aimed to evaluate age-related changes in skeletal muscle mass among community-dwelling middle-aged and elderly Japanese.This 12-year longitudinal of a population Japan included 15,948 examinations 1962 men 1990 women. We assessed appendicular (AMM) using dual X-ray absorptiometry calculated the index (SMI) AMM divided by height squared (kg/m(2) ). Low was defined as minus two standard deviations below mean for young healthy adults. Leg extension power (watts) measured an...
To clarify the effectiveness of dietary diversity, calculated by records, on cognitive decline.Data were derived from National Institute for Longevity Sciences - Longitudinal Study Aging. Participants comprised 298 men and 272 women aged 60-81 years at baseline (second wave) who participated in follow-up study (third to seventh least once. Cognitive function was assessed with Mini-Mental State Examination all waves. Dietary diversity determined using Quantitative Index Diversity based a...
Frequencies and circumstances of falls were assessed among 1030 middle-aged elderly people who participated in the NILS-LSA (National Institute for Longevity Sciences, Longitudinal Study Aging) from November, 1997 to March, 1999 responded questionnaires. The variables analyzed present study demography history past one year. Circumstances falls, e.g. time, location, activities associated with cause degree injury due asked when subjects experienced a fall. Fear falling was also investigated...
AbstractPurpose. Previous cross-sectional Japanese studies have shown that intraocular pressure (IOP) decreases with age. However, central corneal thickness (CCT) variation should also be considered when examining the relationship between age and IOP, since tonometry has an inherent measurement error due to CCT variations. This study investigates influence of on age-IOP in a population. Methods. The right eyes 1317 subjects from 40 80 years old selected general population using random...
This study examined associations between physical activity and depressive symptoms in 1,151 community-dwelling adults Japan. Physical was measured using a pedometer, whereas were assessed with the Center for Epidemiological Studies-Depression Scale. A structural equation modeling cross-lagged panel design revealed that older (65-79 years of age), daily walking at baseline predicted fewer 2-year follow-up, even after adjusting confounders. In contrast, association not confirmed middle-aged...
Silent brain infarcts (SBI) and white matter lesions are relatively common neuroimaging findings, especially in the elderly population. The genetic background for SBI a large Japanese general population was investigated.Subjects were recruited from participants National Institute Longevity Sciences, Longitudinal Study of Aging. Genotyping methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation MRI examination performed 1721 subjects free any history stroke. diagnosed findings.Of...
Serum uric acid (SUA) is related not only to an increased risk of gout, but also cardiovascular diseases. However, real age-related changes in SUA remain unknown.Longitudinal population-based study epidemiological follow-up data SUA, body mass index (BMI), and alcohol intake was conducted at a health examination center between 1989 1998. The subjects were 80,506 Japanese office workers or their families (50,157 men 30,349 women) with average age 44.5 years for the 43.7 women.SUA all birth...
To validate the Clock Drawing Test (CDT) as a screening method for detecting mild cognitive impairment (MCI) and to find appropriate scoring protocol its cutoff point, we compared sensitivity specificity of three CDT protocols. Subjects included 219 outpatients with memory complaints, who were attending geriatric clinic. Cahn’s protocol, point 7, was more successful at differentiating clinically diagnosed MCI subjects from normal elderly individuals, higher (74.7%) (75.6%), than other The...
Although bone mineral density (BMD) is a complex trait that influenced by both genetic and environmental factors, heritability studies in twins families have shown factors account for 60-85% of the variance BMD. We examined relations six candidate gene polymorphisms to BMD community-dwelling women men. The 2238 subjects (1110 women, 1128 men) were aged 40-79 years randomly recruited population-based prospective cohort study aging age-related diseases Japan. at distal proximal radius was...
We assessed longitudinal relationships between baseline testosterone and muscle mass changes in Japanese men. Data were collected from community-dwelling 957 adult men who participated a study of ageing biennially 1997–2010. Appendicular (AMM) was measured with dual-energy X-ray absorptiometry at follow-up examinations. The cut-off point sarcopenia defined as skeletal index (AMM/height2) < 6.87 kg/m2. Total (TT) free (FT) radioimmunoassay. calculated FT (cFT) determined formula using...
Introduction Brain atrophy is associated with impairment in cognitive function and learning function. The aim of this study was to determine whether daily physical activity prevents age-related brain progression. Methods participants were 381 men 393 women who had participated both the baseline follow-up surveys (mean duration = 8.2 yr). Magnetic resonance imaging frontal temporal lobes performed at time surveys. activities total energy expenditures recorded uniaxial accelerometry sensors....
A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in research expanded to brain imaging analyses with auditory function. The aim this study was investigate the link between ability, which assessed using pure-tone audiometry, volume regions, specifically hippocampus, entorhinal cortex, Heschl's gyrus, total gray matter, Freesurfer software T1-weighted magnetic resonance imaging. data for 2082 samples (age range = 40-89 years) were...
The relationship between physical frailty and regional gray matter volume in the brain was investigated among community-dwelling older Japanese people.Participants (N = 835; age range 65-89 years) were adults Obu City Higashiura Town Aichi Prefecture, Japan. Physical determined by modified criteria of Cardiovascular Health Study, which included weight loss, slowness, weakness, exhaustion, low activity. Regional volumes evaluated from 3-dimensional T1-weighted magnetic resonance images...
Hearing impairment (HI) is a major global health concern. In addition, social networks are important for healthy aging. This study aimed to examine the association between HI and relationships. was conducted by National Institute Longevity Sciences as part of its Longitudinal Study Aging with 1176 Japanese participants aged 60 years or older (mean age 71.0 ± 7.4). The convoy model used evaluate participants' network size. A pure-tone average hearing level (HL) 0.5, 1, 2, 4 kHz in better ear...