A5027007213- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Physical Activity and Health
- Cardiovascular and exercise physiology
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Frailty in Older Adults
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Regulation of Appetite and Obesity
- Ophthalmology and Eye Disorders
- Sports Performance and Training
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biochemical effects in animals
- Musculoskeletal pain and rehabilitation
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
Tottori University
2004-2024
Cincinnati Children's Hospital Medical Center
2024
University of Tsukuba
1997-2019
National Center for Geriatrics and Gerontology
2003-2018
Chubu National Hospital
2003
Mie University
2003
American College of Surgeons
1999
Omron (Japan)
1997
Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and β cell dysfunction. In recent studies reported that several markers associated with sensitivity in skeletal muscle, Adiponectin other parameters, such as fatty acid-binding protein (FABP4), have been to regulate resistance, but it remains unclear which factor mostly affects T2DM. this cross-sectional study, we evaluated the relationships between kinds of biomarkers secretion T2DM healthy controls. We recruited 30...
Background Screening for undiagnosed type 2 diabetes mellitus is recommended Asian Americans with a body mass index ≥23. However, the optimal cut-off score predicting risk of in Japanese people not well known. The aim this study was to determine best insulin resistance and population. Methods This had two parts, clinical investigation retrospective observational investigation. In part study, 58 participants (26 32 non-diabetics) underwent hyperinsulinemic-euglycemic clamp from which their...
We performed an electrophysiological study to investigate ion transport of pendrin and thereby understand the pathogenesis Pendred syndrome. Using pendrin-transfected COS-7 cells, we could show that transports both iodide chloride measured as voltage-dependent inward outward membrane currents. Chloride in culture medium, [Cl-]o, was efficiently exchanged with cytoplasmic iodide, [I-]i, under physiological concentrations, indicating is important for uptake efflux. Although exchange [I-]o,...
Fucoidan is derived from seaweed widely used in Japanese cuisine, but little known about its influence on glucose metabolism. To obtain information the physiological effects of fucoidan metabolism, digestive system, and gustatory system controlling taste sensation patients with type 2 diabetes, we conducted a randomized, double-blind, placebo-controlled study.Thirty diabetes diet therapy were recruited an outpatient clinic (22 men 8 women aged 59.10 ± 13.24 years, body mass index: 25.18...
<i>Objective</i>. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects animal and cell culture models may promote resistance nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs human serum. Here, we use this to investigate relationship between secretion patients with T2DM. <i>Methods</i>. Our study involved 15...
In Graves' ophthalmopathy (GO), fibrosis in extraocular muscles (EOMs) may be related to intravenous glucocorticoid (ivGC)-resistant diplopia. Signal intensity (SI) of magnetic resonance imaging (MRI) T1 mapping can quantify properties EOM components, including fibrosis. We investigated features GO patients with diplopia using SI and the predictive value response ivGCs.We performed a cross-sectional study that included 13 active patients, 34 inactive history diplopia, 20 disappearance, 14...
Introduction Hepatic insulin clearance (HIC) is an important pathophysiology of type 2 diabetes. HIC was reported to decrease in patients with diabetes and metabolic syndrome. However, hyperglycemia suggested enhance HIC, it not known whether poorly controlled increases We investigated increased diabetes, associated resistance incretins. Research design methods performed a meal tolerance test the hyperinsulinemic–euglycemic clamp 21 calculated postprandial C-peptide area under curve...
Graves' ophthalmopathy (GO) is a common manifestation of disease (GD); however, its pathogenesis not well understood. Recently, the dysregulation regulatory T cells (Tregs) has been thought to be closely associated with and clinical symptoms autoimmune disease. We therefore evaluated whether cell subsets, including Tregs, are GO symptoms. In this observational study we 35 GD patients overt (GOs) 28 without (non-GOs). Fifteen healthy euthyroid served as controls (HCs). Peripheral blood...
Abstract Objective Weight loss following vertical sleeve gastrectomy (VSG) in youth can range from 10% to 50%. We examined whether there are differences demographic or metabolic parameters before VSG who achieve above‐average weight (AAWL) versus below‐average (BAWL) at 1 year post and if with BAWL still health improvements VSG. Methods Demographic, anthropometric, clinical lab data were collected 1, 3, 6, 12 months after Results Forty‐three a mean age of 16.9 (SD 1.7) years studied; 70%...
In mitochondrial diabetes, apoptosis of β-cells caused by stress plays an important role in impaired insulin secretion. Several studies have reported that coenzyme Q10 (CoQ10) has therapeutic effects on but no reports examined the fundamental effectiveness or mechanism CoQ10 diabetes. We previously a Japanese article protective pancreatic against using mouse β-cell line MIN6 and staurosporine (STS). Here, we report protects cells STS describe more detailed apoptotic cascade. Apoptosis was...
Fortified milk and resistance training (RT) increase muscle mass, strength, physical performance in older adults, but it remains unclear whether RT combined with aerobic (AT) would have stronger effects on these outcomes. The purpose of this study was to examine the (ART) fortified consumption adults.
One hypothesis regarding the cause of diabetic complications is that advanced glycation end products (AGEs) bind to AGE receptor and induce changes in gene expression. However, what AGEs exist vivo how individual are produced impact body metabolic process diabetes not understood. We developed a new precise method measure using LC-MS/MS with column measured 7 free AGEs, including N(6)-carboxymethyllysine (CML), N(6)-(1-carboxyethyl)-l-lysine (CEL)...
Non-alcoholic fatty liver disease (NAFLD) is a chronic related to metabolic syndrome. No standard pharmacological treatment has yet been established. We retrospectively evaluated the efficacy of pemafibrate in 16 NAFLD patients (11 men and 5 women; median age, 59 years; range, 27-81 years) who had taken for at least one year. They were all diagnosed with according imaging clinical criteria. administered from October 2018 2021 (median, 94 weeks; 56-157 weeks). Serum triglyceride was...
Abstract Aims/Introduction The aim of the present study was to evaluate properties glucagon stimulation test ( GST ) and normal meal tolerance NMTT in patients with type 2 diabetes. Materials Methods We enrolled 142 diabetes, carried out a . using calorie‐controlled based on an intake 30 kcal/kg ideal bodyweight/day. calculated change C‐peptide immunoreactivity (Δ CPR by subtracting fasting from 6 min after 1‐mg injection or 120 ). Results Mean Δ for 2.0 ng/ mL , 3.1 A total 104 had greater...
Abstract Sodium–glucose cotransporter 2 inhibitor (SGLT2i) treatment is a therapeutic approach for type diabetes mellitus (T2DM). Some reports have shown that SGLT2i improves insulin resistance; however, few studies evaluated resistance by the glucose clamp method. Hepatic clearance (HIC) new pathophysiological mechanism of T2DM. The effect on hepatic and not well known. We investigated resistance, secretion, incretin levels, body composition, clearance. conducted meal tolerance test (MTT)...
Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme involved in alcohol metabolism. ALDH2 polymorphism has been reported as a risk factor for type diabetes mellitus (T2DM) and associated with liver insulin resistance due to consumption non-diabetic individuals. Herein, we investigated the association between polymorphisms patients T2DM.We performed meal tolerance test hyperinsulinemic-euglycemic clamp on 71 Japanese participants: 34 T2DM, 37 participants. We analyzed (ALDH2 rs67); GG was...
Background Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim this study to analyze an effective resistance (IR) index that minimally affected by HIC. Methods Our involved 20 participants with T2DM and 21 healthy without (Non-DM). Participants underwent a meal tolerance test from which plasma glucose, serum C-peptide immunoreactivity (CPR) were measured, HOMA-IR HIC calculated. then hyperinsulinemic-euglycemic clamp...
Background Training peer leaders to deliver patient education is expected be a low-cost approach providing healthcare in urban-poor areas affected by shortage of professionals. The purpose this study was examine the effects training program on self-efficacy and knowledge with type 2 diabetes.
Abstract Background Dipeptidyl peptidase 4 inhibitor (DPP4i) is an effective medicine for type 2 diabetes mellitus (T2DM). Some articles reported DPP4i improves insulin secretion and resistance. However, these effects are not well established by glucose clamp test meal in Japanese. We investigated the effect of on resistance using tolerance (MTT). Methods performed a MTT, hyperinsulinemic-euglycemic 8 Japanese patients with T2DM. This study was single-arm study. measured fasting postprandial...
Epstein-Barr virus (EBV) is a human herpes that latently infects B lymphocytes. When EBV reactivated, host cells differentiate into plasma and produce IgM-dominant antibodies as well many progeny virions. The aims of the present study were to confirm IgM dominance thyrotropin-receptor (TRAbs) produced by reactivation investigate roles TRAb-IgM in Graves' disease. Peripheral blood mononuclear (PBMCs) containing TRAb-producing stimulated for reactivation, TRAb-IgG measured ELISA. purified...