Cisplatin (cis-diamminedichloroplatinum II), an anticancer chemotherapeutic agent with the dose-limiting side effect of nephrotoxicity, caused a statistically significant increase in lipid peroxidation, monitored by measuring production malondialdehyde, rat kidney 72 hr after injection. Treatment rats beforehand antioxidant α-tocopherol or N-N′-diphenyl-p-phenyl-enediamme (DPPD) effectively decreased such peroxidation. DPPD was more effective inhibitor than α-tocopherol, since it is known...

Aim Little is known about longitudinal changes of body composition measured by dual‐energy X ‐ray absorptiometry ( DXA ) in middle‐aged and elderly individuals. We evaluated composition, age sex differences appendicular skeletal muscle mass. Methods Participants were 1454 community‐dwelling Japanese men women aged 40–79 years. Body at baseline 6‐year follow up was . Results Fat increased significantly all ages, their 40s 50s. Among men, arm lean tissue mass LTM changed 0.9%, −0.5%, −1.4%...

Whether smokers and former have worse lipid profiles or glucose levels than non-smokers remains unclear.

Cisplatin (cis-diamminedichloroplatinum II), an anticancer chemotherapeutic agent with the dose-limiting side effect of nephrotoxicity, caused a statistically significant increase in lipid peroxidation, monitored by measuring production malondialdehyde, rat kidney 72 hr after injection. Treatment rats beforehand antioxidant α-tocopherol or N-N′-diphenyl-p-phenyl-enediamme (DPPD) effectively decreased such peroxidation. DPPD was more effective inhibitor than α-tocopherol, since it is known...

Body fat distribution and abdominal fatness are indicators of risks for coronary heart disease. However, the relationships between resting energy expenditure (REE) body or unclear. We examined REE with whole-body (waist, hip waist-to-hip ratio: WHR) (intra-abdominal fat: IF subcutaneous SF) after adjustment composition. 451 men 471 women were subdivided into two groups, 40–59 years: middle-aged group 60–79 elderly group. was measured by an indirect calorimetry system. Percentage mass (%FM),...

Abstract We investigated the relationship of polymorphisms in cholecystokinin 1 receptor [ CCK1R ; G to T (n‐128), A (n‐81)] and β 3 ‐ adrenergic (β AR Trp64Arg) with midlife weight gain. The participants were 1012 Japanese men women (40 59 years age). Their at 18 old was obtained from a questionnaire. Weight change defined as current minus old. Subjects grouped into four categories by these genotypes: W/W = noncarriers, W/H Arg 64 carriers , H/W (n‐128) or (n‐81) H/H carriers. In men,...

To prevent a decline in gait with age, it is necessary to investigate age-related changes performance and detect related factors. The purpose of this study was assess the association between ability leg extension power among middle-aged elderly people. Height, weight, maximum velocity (MGV) (LEP) were measured 752 males females who participated National Institute for Longevity Sciences, Longitudinal Study Aging (NILS-LSA). Age-related MGV LEP assessed. There significant trends height,...

This study aimed to assess the relationship between weight gain from early adulthood and visceral fat accumulation.The participants were 549 men aged 42 64 years who randomly selected local resident registry for National Institute Longevity Sciences' neighbourhood. They asked recall their at 18 of age, then, post-18 weight-change values calculated each participant (their current minus 18). The divided according median body mass index (BMI) age (initial BMI) (<20.14 ≥20.14 kg m-2). Visceral...

大規模集団の縦断データを用いて, 年齢階級別に体重変動と血清脂質および血圧の変化の関係について検討した. 人間ドックを連続2年間受診した19歳～88歳の男女17,689名を対象として, 1年間の体重変動による血清脂質および血圧の変化量を, 性, BMI, 喫煙, 飲酒, 各血清脂質または血圧の観察開始時の値で調整後, 線形回帰分析より年齢階級別 (45歳未満, 45歳以上65歳未満, 65歳以上) に推定した. その結果, いずれの年齢階級でも体重変動により血圧に有意な変化がみられ, 体重減少によって血圧は低下し, 体重増加によって上昇した. 一方血清脂質では, 体重変動との関係に年齢階級による違いが認められた. 65歳未満では体重の減少によって総コレステロール, 中性脂肪, βリポ蛋白は低下した. しかし, 65歳以上で体重減少により有意な変化がみられたのは中性脂肪とβリポ蛋白で, 総コレステロールには有意な変化はみられなかった. また, 体重増加との関係をみてみると, 65歳未満では総コレステロール, βリポ蛋白の増加, HDLコレステロールの減少がみられた....

Underwater weighing is based on the assumption that fat-free body density roughly constant among humans. This should be examined, because may in fact depend bone mineral and water contents of body, with fat excluded. The purpose this study was to investigate effects content (BMC) (BMD) accuracy measured underwater. subjects were 12 young men (25.1±3.7 years, mean ± SD), some whom trained athletes. BMC BMD by dual-energy x-ray absorptiometry (DXA), as fat, a percentage weight; method not same...

NaClにKClを20%増しに加えた食塩6種を作り, これを白菜, きゅうり, 大根のキムチに使用して, 許容されるKClの添加割合を, 成分分析, 官能検査等により検討した。その結果は次のとおりであった。1) K, Naは, 使用するK塩添加食塩中のK, Na量に比例して漬物中に浸透した。2) Ca, Mg, アミノ態窒素, 有機酸については, 測定値に一定の傾向が認められず, K塩添加食塩中のK量によって影響をうけることはなかった。3) 官能検査の結果は, 色を除いては, 全般にK量の増加に従って好まれない傾向がみられた。総合評価では, 韓国人では全試料とも100%および80%K塩添加食塩を用いたものは, NaCl100%のものに比べて1または5%危険率で有意に好まれなかった。日本人では, 60%K塩添加食塩を用いたキムチでも有意に好まれないものがあった。4) K塩添加食塩を使用したキムチに対する韓国人と日本人の嗜好の相関を検討した結果, 色については, 嗜好に差があることがうかがわれたが, 香り, 味, 総合評価等については, ほぼ一致する傾向がみられた。

こんぶだし汁の味を特徴づける成分を明らかにするため, 分析値をもとに調製したグルタミン酸, アスパラギン酸, 5'-AMP, マンニトール, 塩化カリウム, 塩化ナトリウムよりなる合成だし汁から, 一成分ずつを除去し, オミッションテストを行った.また市販の合成だし汁に塩化カリウムと塩化ナトリウムの割合を変えて加え, 味の違いを検討した.結果は, 次のように要約された.1) こんぶだし汁の味に大きく関与する成分は, グルタミソ酸, カリウム, ナトリウムであった.2) 市販の合成だし汁に, 塩化カリウムを添加した塩化ナトリウムを加えたところ, 塩化ナトリウムのみを加えた場合よりも総合評価において高く評価された.