A5088851018- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Frailty in Older Adults
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Immune cells in cancer
- Venous Thromboembolism Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Tracheal and airway disorders
- Bladder and Urothelial Cancer Treatments
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
Tottori University
2015-2024
Weatherford College
2024
Osaka International Cancer Institute
2017-2019
Sapporo Medical University
2002-2008
University of Tsukuba
1991-2007
Fukuoka University
2007
Pfizer (United States)
2001
Sapporo City General Hospital
1998
Ipsen (France)
1991
Abstract Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of tumoral evasion. However, role B (Bregs) this remains unclear. Here, we identified a for Bregs evasion gastric cancer (GC) patients. The frequency peripheral was significantly higher GC patients than healthy controls ( P = 0.0023). Moreover, CD19 + CD24 hi CD27 tissue blood and tissue. Carboxyfluorescein succinimidyl ester labeling revealed could suppress proliferation autologous...
The molecular genetic defect of a female patient with apolipoprotein A-I (apoA-I) deficiency and premature atherosclerosis was examined. Her parents were first cousins. plasma density fraction from 1.063 to 1.21 g/ml contained no apoA-I on SDS/PAGE measurable high lipoprotein cholesterol. Southern blot hybridization showed gross abnormality be present in the patient's gene homozygosity for haplotype restriction fragment length polymorphisms region. Sequencing after amplification by PCR...
Abstract Background Co‐signaling molecules play an important role in T cells. Programmed death‐1 (PD‐1) is immunoinhibitory receptor and its overexpression on cells appears to be involved immune evasion cancer patients. The present study was designed investigate PD‐1 expression relationship with gastric Methods CD4+ CD8+ obtained from peripheral blood mononuclear (PBMC), normal mucosa, tissue evaluated by multicolor flow cytometry. Results patients significantly higher than that controls....
Background: A recent study demonstrated that immune-checkpoint molecules are associated with tumoral immune evasion. Materials and Methods: Programmed cell death protein 1 (PD-1) expression on CD4<sup>+</sup> CD8<sup>+</sup> T-cells obtained from gastric cancer tissue was evaluated by multicolor flow cytometry. Immunohistochemical staining also performed to evaluate programmed ligand-1 (PD-L1) cells. Results: There were statistically significant correlations between PD-L1 age, histology,...
The association between the presence of sarcopenia and systemic inflammatory response is unclear in patients with esophageal cancer. This study was performed to investigate relationship clarify effect these factors on prognosis cancer.This included 163 patients' body composition assessed before esophagectomy using multifrequency bioelectrical impedance. were investigated surgery.Sarcopenia significantly associated a high C-reactive protein-to-albumin (CRP/Alb) ratio (p=0.046). Patients worse...
Detailed evaluation of the overall incidence postoperative pancreatic fistula (POPF) after early drain removal (EDR) in distal pancreatectomy (DP) is lacking. This study aimed to assess complications, including POPF, with EDR following DP. Ninety-nine patients who underwent DP regardless fluid amylase level between January 2017 and December 2024 were enrolled this study. Data retrospectively analyzed evaluate POPF. The POPF was 31.3% (31/99 patients), which clinically relevant requiring...
Several studies have investigated the safety of laparoscopic gastrectomy (LG) for gastric cancer (GC). However, many these excluded older patients, and few multicenter compared LG open (OG) in patients with GC. We postoperative short- long-term outcomes OG >75 years old GC a study. The study included 926 aged who underwent from January 2003 to December 2017 at 12 regional hospitals. After propensity score-matching (PSM), two surgical groups' were analyzed. PSM was applied variables such as...
SUMMARY Fas (APO-1/CD95)-mediated apoptosis plays an important role in liver cell destruction viral hepatitis. Using sandwich ELISA, we measured serum levels of soluble (sFas) patients with hepatocellular carcinoma (HCC) who were positive for hepatitis B surface antigen (HBsAg) or anti-hepatitis C virus (HCV) antibody. sFas significantly higher HCC (median 4·07 ng/ml; range 0·14–29·18 ng/ml) than age-matched healthy donors (0·29 0–4·90 (P &lt; 0·0001) and HBsAg anti-HCV antibody-positive...
Nutritional status is strongly associated with cancer prognosis. The aim of this study was to identify the most useful combination nutrition-related serum markers for predicting prognosis patients colorectal (CRC).A total 523 who underwent proctocolectomies CRC at our hospital were enrolled in study. Serum concentrations albumin, cholinesterase and cholesterol, peripheral lymphocyte count (TLC) used as markers.In multivariate analysis markers, albumin levels found be independent prognostic...
Background/Aim: Although many prognostic indicators have been identified for resectable gastric cancer (GC), unresectable GC (urGC) not widely studied. The aim of the current study was to investigate that could be determined through routine blood examinations in patients with urGC. Patients and Methods: We retrospectively analyzed clinicopathological factors 92 advanced recurrent adenocarcinoma. Results: Based on receiver operating curve analysis, neutrophil–to–lymphocyte ratio (NLR) had...
Abstract Background Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate function T cells. Although recent studies indicate PD-1 also expressed on other cells besides cells, its role remains unclear. This study aims to evaluate expression macrophages and examine effect anti-tumor immunity in gastric cancer (GC) patients. Methods The frequency + obtained from GC tissue was determined by multicolor flow cytometry ( n = 15). Double...
Despite carrying better overall prognoses, some node-negative gastric cancer patients die from recurrent malignancies. Identifying factors associated with disease-specific survival in adequately staged is important, as these are presumably free of microscopic regional metastases and may derive significant benefit existing or future adjuvant strategies.To investigate prognostic indicators advanced patients, we reviewed 777 who had undergone curative gastrectomies.The 5-year rate 84.9%, which...
Abstract Background Several studies have reported that modified Collard anastomosis is useful for cervical after esophagectomy thoracic esophageal cancer. However, no large‐scale study has confirmed the efficacy of anastomosis. Methods Between 2008 and 2016, 398 consecutive cancer patients who underwent were enrolled in this study. Patients with a short remnant esophagus excluded. We investigated utility by comparing results postoperative complications using propensity score‐matched analysis...
Abstract Background The geriatric nutritional risk index (GNRI), originally developed as a assessment tool to evaluate mortality and morbidity in older hospitalized patients (i.e., those aged ≥65 years), is regarded prognostic factor several cancers. Body composition also an important consideration when predicting the prognosis of with cancer. This study aimed investigate relationship between GNRI psoas muscle volume (PMV) for survival outcomes pancreatic Methods retrospective evaluated...
Abstract Background Several studies investigated the utility of inflammation and nutritional markers in predicting prognosis patients with gastric cancer; however, best predictive ability remain unclear. This retrospective study aimed to determine that predicted elderly over 75 years age undergoing curative gastrectomy for cancer. Methods Between January 2005 December 2015, 497 consecutive cancer aged underwent 12 institutions. The geriatric risk index (GNRI), prognostic index,...
Abstract Intraperitoneal (IP) chemotherapy with paclitaxel (PTX) for gastric cancer (GC) peritoneal metastasis (PM) is considered a promising treatment approach, however, there are no useful biomarkers to predict the efficacy of IP therapy. We examined association between intra-peritoneal exosomes, particularly exosomal micro-RNAs (exo-miRNAs), and IP-chemo sensitivity. MKN45 cells that were cultured exosomes from patients who did not respond therapy PTX (IP non-respond group) exhibited...
Background The incidence of gastric cancer (GC) among older adults is increasing. Therefore, determining postoperative age-associated prognostic factors clinically important. This study retrospectively investigated the significance serum albumin level in GC patients.