A5101873827- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Vaccine Coverage and Hesitancy
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Phagocytosis and Immune Regulation
- Mesoporous Materials and Catalysis
- Cancer Immunotherapy and Biomarkers
- Carbon dioxide utilization in catalysis
- Chronic Lymphocytic Leukemia Research
- Data Visualization and Analytics
- Amoebic Infections and Treatments
- biodegradable polymer synthesis and properties
- Antimicrobial agents and applications
- Layered Double Hydroxides Synthesis and Applications
- Silicone and Siloxane Chemistry
- Coccidia and coccidiosis research
- Chemical Synthesis and Analysis
- Parasitic Infections and Diagnostics
Yokohama City University
2021-2023
Musashino University
2023
Japan Wildlife Research Center
2023
National Institute of Health Sciences
2021-2022
Waseda University
2021
Tottori University
2019
Abstract Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of tumoral evasion. However, role B (Bregs) this remains unclear. Here, we identified a for Bregs evasion gastric cancer (GC) patients. The frequency peripheral was significantly higher GC patients than healthy controls ( P = 0.0023). Moreover, CD19 + CD24 hi CD27 tissue blood and tissue. Carboxyfluorescein succinimidyl ester labeling revealed could suppress proliferation autologous...
Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It important to select an appropriate linker, E3 ligase ligand, a target ligand in development; however, it necessary synthesize large number PROTACs through trial error. Herein, using docking simulation ternary complex hematopoietic prostaglandin D synthase (H-PGDS) degrader, H-PGDS, cereblon, we have succeeded developing PROTAC(H-PGDS)-7 (6),...
Although hematopoietic prostaglandin D synthase (H-PGDS) is an attractive target for treatment of a variety diseases, including allergic diseases and Duchenne muscular dystrophy, no H-PGDS inhibitors have yet been approved these diseases. Therefore, the development novel agents having other modes action to modulate activity required. In this study, chimeric small molecule that degrades via ubiquitin-proteasome system,
MODAN is a multi-objective Bayesian framework for automated design of antimicrobial peptides containing various non-proteinogenic amino acids and side-chain stapling.
Degradation of hematopoietic prostaglandin D2 synthase (H-PGDS) by proteolysis-targeting chimeras (PROTACs) is expected to be important in the treatment allergic diseases and Duchenne's muscular dystrophy. We recently reported that PROTAC(H-PGDS)-7 (PROTAC1), which composed H-PGDS inhibitor (TFC-007) cereblon (CRBN) E3 ligase ligand (pomalidomide), showed potent degradation activity. Here, we investigated structure-activity relationships PROTAC1, focusing on C4- or C5-conjugation...
Antimicrobial peptides (AMPs) have attracted attention as next-generation antimicrobial drugs. Designing AMPs while considering multiple properties, such activities and toxicity, requires numerous trials errors by chemists. In this study, we propose MODAN, a machine learning-assisted AMP design framework based on multi-objective Bayesian optimisation. The primary advantage of MODAN is its ability to handle various non-proteinogenic amino acids, which recently shown the potential activity...
Pseudomonas acidophila is a bacterial strain producing poly(3-hydroxyalkanoic acid) (PHA) copolymer from low-molecular-weight organic compounds such as formate and acetate. The genes responsible for PHA production were cloned in cosmid pIK7 containing 14.8-kb HindIII fragment of P. DNA. With the aim developing means CO(inf2), was introduced into polymer-negative mutant chemolithoautotrophic bacterium Alcaligenes eutrophus PHB(sup-)4. However, recombinant produced homopolymer 3-hydroxybutyric...
Abstract Interlayer silylation of layered sodium octosilicate (Na‐Oct) with various organoalkoxysilanes was conducted using hexadecyltrimethylammonium ion‐exchanged (C 16 TMA‐Oct) as an intermediate in the presence or absence tetrabutylammonium fluoride (TBAF). The degree increased by adding TBAF. It is suggested that F − ions perform a nucleophilic attack on alkoxysilanes, which promotes reaction. C TMA‐Oct silylated octyltriethoxysilane 8 TES) 3‐mercaptopropyltriethoxysilane (MPTES) to...
In reptiles, infection with Cryptosporidium parasite can be lethal, especially in species of family Eublepharidae such as Eublepharis macularius and Goniurosaurus splendes species. We investigated the presence spp. wild spp., five islands Japan. Nested PCR was performed to detect 38 fecal samples 9 reptile from Japan, 3 (3/8) positive kuroiwae sengokui Tokashikijima, Okinawa Prefecture were detected. A BLAST search detected gene sequences revealed that all identified serpentis, a...
We have proposed a multi-objective Bayesian framework for the automated design of antimicrobial peptides that considers non-proteinogenic amino acids and side-chain stapling. Furthermore, we succeeded in designing potent low haemolytic activities within two cycles, based on strategy chemists do not usually consider.
This paper presents a method for visualizing members' activities in series of multiple group work sessions with the same members each time, using time-series feature comparison method. It is becoming increasingly important organizations to produce deliverables through work. However, inefficient owing lack review itself, which performed by have become problem. If it possible capture and visualize who talking about what when work, will be reflect on improve its efficiency In this study, we...
Hematopoietic prostaglandin D synthase (H-PGDS) is an attractive target for the development of therapeutic agents Duchenne muscular dystrophy (DMD) and other H-PGDS-related diseases. We have recently developed H-PGDS degrader PROTAC(H-PGDS)-1 , which a chimeric molecule in TFC-007 (that binds to H-PGDS) pomalidomide cereblon [CRBN]) were conjugated PEG5 linker. Herein, using docking simulation ternary complex degrader, H-PGDS, CRBN, we succeeded developing PROTAC(H-PGDS)-7, new that does not...