A5075835917- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Metastasis and carcinoma case studies
- Bladder and Urothelial Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Frailty in Older Adults
- Ferroptosis and cancer prognosis
- Dysphagia Assessment and Management
- Electrolyte and hormonal disorders
- Intestinal and Peritoneal Adhesions
- Enhanced Recovery After Surgery
- Cancer, Stress, Anesthesia, and Immune Response
- Light effects on plants
- Biocrusts and Microbial Ecology
- Educational Robotics and Engineering
- Heme Oxygenase-1 and Carbon Monoxide
Tottori University
2018-2023
Utsunomiya University
2020
Kanto Gakuin University
2019
Abstract Background Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate function T cells. Although recent studies indicate PD-1 also expressed on other cells besides cells, its role remains unclear. This study aims to evaluate expression macrophages and examine effect anti-tumor immunity in gastric cancer (GC) patients. Methods The frequency + obtained from GC tissue was determined by multicolor flow cytometry ( n = 15). Double...
Background The purpose of this study was to compare postoperative complications and nutritional status between esophagogastrostomy double-tract reconstruction in patients who underwent laparoscopic proximal gastrectomy, assess the advantages both surgical procedures.
The systemic inflammatory response resulting from the complex interactions between cancer and host plays an important role in development. Recently, lymphocyte-C-reactive protein ratio (LCR), which is a hematological biochemical marker that reflects nutritional status, has been reported to be associated with poor survival. Similar results were observed patients certain types. However, these studies focused on preoperative LCR, thus far, no have relationship postoperative LCR prognosis...
Abstract Background Ferroptosis suppressor protein 1 and glutathione peroxidase 4 have been identified as key molecules in two independent pathways associated with ferroptosis inhibition. This study investigated the prognostic significance clinical associations of FSP1 GPX4 expression esophageal squamous cell carcinoma (ESCC) assessed therapeutic potential regulating these ESCC cells. Methods Immunohistochemical analysis was performed on surgical specimens 97 patients for expression. To...
We compared short- and long-term clinical outcomes including inflammatory marker levels between robotic gastrectomy (RG) laparoscopic (LG) to define the advantages of RG over LG.We enrolled 209 patients with gastric cancer who underwent curative distal gastrectomy. LG LG. C-reactive protein (CRP) levels; CRP-to-albumin, neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios; prognostic nutritional index were as systemic markers.RG was associated a longer operative time. The incidence...
Abstract Background This study was conducted to assess the long-term outcomes of elderly patients among propensity-score-matched gastric cancer after curative gastrectomy and propose proper management patients. Methods We enrolled 626 with who underwent at our institution between January 2004 December 2015. To minimize selection bias 2 groups, propensity score matching performed. Results Patients were divided into an group over 75 years old (EP group; n = 186) a non-elderly (NEP 440). After...
Abstract Background The mortality rate of patients with unresectable gastric cancer (UGC) has decreased the development chemotherapies and surgical techniques. However, survival remains low. We retrospectively examined prognostic significance pretreatment skeletal muscle mass index (SMI) nutritional inflammatory factors in UGC. Methods This study included 83 diagnosed UGC at Tottori University Hospital who received palliative chemotherapy based on 5-fluorouracil. Pretreatment computed...
Patients who undergo gastrectomy for gastric cancer (GC) are likely to have nutritional difficulty after surgery. Readmission due is common in such patients. Thus, this study, we aim identify the predictive indicators readmission patients underwent GC.
The standard procedure for remnant gastric cancer after esophago-proximal gastrectomy is total resection of the stomach considering blood supply.However, sometimes surgery may be too invasive due to severe adhesion in thoracic and mediastinal cavity.The supply depends on right gastroepiploic artery artery.Therefore, preservation proximal region thought anatomically impossible.We report a case that developed more than 12 years lower esophagectomy plus Siewert Type I squamous cell carcinoma.We...
Abstract Background We retrospectively examined the relationship among skeletal muscle mass index (SMI), prognosis, and chemotherapy side effects in patients with recurrent gastric cancer (RGC). Methods Sixty-seven who developed recurrence after undergoing curative gastrectomy for at Tottori University Hospital received palliative were included this study. Pretreatment computed tomography was performed to measure (SMM) cross-sectional SMM third lumbar vertebra. focused on haematologic...
Immune-check point inhibitors (ICPIs) for treatment of cancer patients sometimes induce potentially life-threatening immune-related adverse events (irAEs), which predict ICPIs efficacy. Prediction irAEs would be useful management and prediction This study aimed to determine predictors in with recurrent or unresectable advanced gastric (RUGC) treated nivolumab.Seventy-eight RUGC nivolumab at nine institutions between January 2017 April 2020 were included this study. The usefulness specific...
Thoracoscopic esophagectomy has been extensively used worldwide as a curative surgery for patients with esophageal cancer; however, complications such anastomotic leakage and stenosis remain major concern. Therefore, the objective of this study was to evaluate efficacy circular stapling anastomosis indocyanine green (ICG) fluorescence imaging, which standardized cervical esophagogastric after thoracoscopic esophagectomy.Altogether, 121 cancer who underwent radical lymph node dissection from...
Background Esophagectomy is an invasive and complication-prone surgical procedure. Therefore, a tool that can predict the occurrence of postoperative complications may be useful for perioperative management. In this study, we investigated whether modified frailty index (mFI) could predicting esophagectomy.
Background/Aim: M1 macrophages have antitumour effects, while M2 promote tumour proliferation and invasion. The clinical significance of the M2-specific marker CD204 has not been elucidated in colorectal cancer (CRC). We investigated prognostic CD204- CD68-positivity specimens from patients with CRC examined effects polarized-macrophages on proliferative invasive potentials cell lines vitro. Materials Methods: Surgical 206 Stage II III were by immunohistochemistry. Proliferation invasion...
There have been two reports on preserving the proximal gastric tube by using intraoperative indocyanine green (ICG)-based photodynamic detection to evaluate blood flow through anastomosis for cancer after esophagectomy. However, in those cases, period since first operation was > 3 years 11 months, and there no of cases with < 1-year periods operation.A 59-year-old man underwent video-assisted thoracic subtotal esophagectomy reconstruction courses preoperative chemotherapy middle esophageal...
Colonic metastasis is uncommon in patients with hepatocellular carcinoma (HCC). In the past, extrahepatic of HCC was not treated aggressively because its poor prognosis. Herein, we describe case a patient who survived for 30 months following resection metastatic tumor ascending colon.An 80-year-old man presented at our hospital symptoms abdominal pain on right side and fever. He had undergone transcatheter arterial chemoembolization posterior segment liver HCC, followed by radiofrequency...
Abstract Background: Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate function T cells. Although recent studies indicate PD-1 also expressed on other cells besides cells, its role remains unclear. This study aims to evaluate expression macrophages and examine effect anti-tumor immunity in gastric cancer (GC) patients. Methods: The frequency PD-1+ obtained from GC tissue was determined by multicolor flow cytometry (n = 15). Double...
Background: Despite improved treatment for gastric cancer (GC), the prognosis of advanced disease remains poor. Further investigation oncogenic sequence GC is needed. Materials and Methods: The expression TYRO3 protein tyrosine kinase in five cell lines was confirmed using western blotting. knockdown cells, bromodeoxyuridine Transwell assays were used to examine functions tumor proliferation invasion. Finally, 138 patients who underwent curative resection (Union International Cancer Control...
A drain is often placed in the abdominal cavity for postoperative monitoring and early detection of complications such as rebleeding pancreatic or bile leaks. Since determining color drainage fluid subjective, an objective method judging needed.The hemoglobin concentration after gastrointestinal surgery was measured using Hemato Check Module, a newly developed instrument capable absorbance analysis with optical sensor. The correlation between results those by existing blood count measuring...
Congenital nephrogenic diabetes insipidus (CNDI) is a rare disease that results in polyuria due to decreased responsiveness the antidiuretic hormone collecting ducts of kidney. Without compensation by drinking large amounts water, dehydration and hypernatremia can rapidly develop. We present case patient originally diagnosed with CNDI who required surgery fasting period adhesive bowel obstruction. The was 46-year-old man CNDI. He prescribed trichlormethiazide but self-discontinued treatment...
Switched Reluctance Motor (SRM) is noticed as low-cost and robust motor. However, position sensor needed to drive SRM it not robust. So, sensorless of strongly expected for practical use. In addition, necessary that torque ripple reduction control SRM. This paper presents a novel estimation method based on nonlinear flux model any controls proposed verified through simulations experiments.
The standard treatment for resectable advanced esophageal squamous cell carcinoma in Japan is surgery followed by neoadjuvant chemotherapy, and it important to predict the effect of chemotherapy before treatment. Therefore, this study aims extract conventional blood examination data, such as tumor markers and/or inflammatory/nutritional index levels, that can pathological response patients with chemotherapy.We retrospectively analyzed medical records 66 thoracic who received curative...