A5007671862- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Infant Development and Preterm Care
- Synthesis and biological activity
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Photoreceptor and optogenetics research
- Mesenchymal stem cell research
- Metabolism, Diabetes, and Cancer
- EEG and Brain-Computer Interfaces
- Pancreatic function and diabetes
- Synthesis and Characterization of Heterocyclic Compounds
- Peroxisome Proliferator-Activated Receptors
- Photosynthetic Processes and Mechanisms
- Alkaline Phosphatase Research Studies
- Respiratory viral infections research
- Synthesis and Reactions of Organic Compounds
- Indoor and Outdoor Localization Technologies
- Cancer, Lipids, and Metabolism
- Cerebral Palsy and Movement Disorders
- Congenital Diaphragmatic Hernia Studies
- Radio Wave Propagation Studies
- Infant Nutrition and Health
- Adipose Tissue and Metabolism
Anjo Kosei Hospital
2019-2024
Meijo University
2023-2024
Japanese Red Cross Nagoya Daiichi Hospital
2022-2024
Nagoya University Hospital
2014-2020
Nagoya University
1994-2019
Kashiwa Municipal Hospital
2012
Nagoya Institute of Technology
2007-2011
Kajima Corporation (Japan)
2011
Matsumoto Livestock Hygiene Service Center
2006
Takeda (Japan)
1984-1997
This study aimed to investigate whether the administration of mononuclear cells derived from human umbilical cord blood (UCBCs) could ameliorate hypoxic-ischemic brain injury in a neonatal rat model. The left carotid arteries 7-day-old rats were ligated, and then exposed 8% oxygen for 60 min. Mononuclear UCBCs using Ficoll-Hypaque technique injected intraperitoneally 6 h after insult (1.0 × 107 cells). Twenty-four hours insult, number positive oxidative stress markers 4-hydroxy-2-nonenal...
Perinatal hypoxic-ischemic (HI) brain injury occurs in 1 1000 live births and remains the main cause of neurological disability death term infants. Cytotherapy has recently emerged as a novel treatment for tissue injury. In particular, mesenchymal stem cells (MSCs) are thought to have therapeutic potential, but little is known about differences according their origin. current study, we investigated effects safety intravenous injection allogeneic bone marrow-derived MSCs (BM-MSCs)...
Mitigation measures implemented during the coronavirus disease 2019 (COVID-19) pandemic remarkably reduced incidence of infectious diseases among children. However, a re-emergence respiratory syncytial virus (RSV) infection was observed in 2021 Japan. We compared clinical characteristics hospitalized patients with RSV before and COVID-19.We retrospectively enrolled children aged <6 years who were 18 hospitals their (January to April 2020, 1675 patients) COVID-19 (September 2020 December...
We have cloned and sequenced the gene that encodes archaerhodopsin, a light-driven H+ pump in Halobacterium sp. aus-1 (Mukohata, Y., Sugiyama, Ihara, K., Yoshida, M. (1988) Biochem. Biophys. Res. Commun. 151, 1339-1345). The nucleotide sequence of this contained an open reading frame which corresponded to protein 260 amino acids with molecular mass 27,851 daltons, including precursor 6 at terminus 2 carboxyl terminus. deduced acid archaerhodopsin exhibited 59 32% homology sequences...
Objective The aim of this prospective multicenter randomized controlled trial was to compare the efficacy silver nitrate cauterization against that topical steroid ointment in treatment neonatal umbilical granuloma. Methods An open-label, non-inferiority conducted from January 2013 2016. primary endpoint for and groups healing rate after 2 weeks treatment, applying a margin 10%. evaluated until completion 3 treatment. Results Participants comprised 207 neonates with newly diagnosed...
To compare magnetic resonance spectroscopy (MRS) metabolite ratios in preterm infants at term-equivalent age with those term and to evaluate the association between MRS metabolites neurodevelopmental outcomes 18 months corrected infants.We studied born a gestational <37 weeks weighing <1500 g during 2009-2013 using age. Infants major brain abnormalities were excluded. The of N-acetylaspartate (NAA) creatine (Cre), NAA choline-containing compounds (Cho) Cho Cre frontal white matter thalamus...
Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are the leading causes of acute tract infection in children, clinical manifestations these infections considered similar. To investigate differences characteristics between HMPV RSV young we prospectively enrolled children ＜ 3 years old who required hospitalization with due to or at 10 hospitals Japan. We 48 141 infection. Patients were older than those High-grade fever was more frequently observed patients infection, whereas...
Recently, cell therapy has been developed as a novel treatment for perinatal hypoxic-ischemic encephalopathy (HIE), which is an important cause of neurological disorder and death, stem cells from human exfoliated deciduous teeth (SHED) express early markers mesenchymal neuroectodermal cells. We investigated the effect SHED HIE in neonatal rats. Seven-day-old rats underwent ligation left carotid artery were exposed to 8% hypoxic treatment. (1 × 105 cells) injected via right external jugular...
Abstract Hypoxic–ischemic encephalopathy (HIE), associated with high mortality and neurological sequelae, lacks established treatment except therapeutic hypothermia. Clinical-grade multilineage-differentiating stress-enduring (Muse) cells (CL2020) demonstrated safety efficacy in nonclinical HIE rat models, thereby leading to an investigator-initiated clinical trial evaluate CL2020 tolerability neonatal as a single-center open-label dose-escalation study 9 neonates moderate-to-severe who...
Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) remains a major cause of mortality and persistent neurological disabilities in affected individuals. At present, hypothermia is considered to be the only applicable treatment option, although growing evidence suggests that cell-based therapy might achieve better outcomes. Dedifferentiated fat (DFAT) cells are derived from mature adipocytes via dedifferentiation strategy called ceiling culture. Their abundance ready availability make them an...
Background/objective: Perinatal hypoxia-ischemia (HI) is an important cause of neonatal death and permanent neurological deficits. Cell therapy using various cell sources has been recently identified as a novel for perinatal HI. This study aimed to investigate whether the administration bone marrow-derived mononuclear cells (BMMNCs) ameliorated HI brain injury in rat model. Methods: Seven-day-old rats underwent ligation left carotid arteries were exposed 8% oxygen 60 min. BMMNCs collected...