A5103282576- Prenatal Screening and Diagnostics
- Neuroendocrine regulation and behavior
- Genetic Syndromes and Imprinting
- Genomic variations and chromosomal abnormalities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Stress Responses and Cortisol
- Human-Animal Interaction Studies
- Retinal Development and Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Medical Research and Treatments
- Pediatric Urology and Nephrology Studies
- Venous Thromboembolism Diagnosis and Management
- Medical Imaging and Pathology Studies
- Dermatological and Skeletal Disorders
- Intramuscular injections and effects
- Histiocytic Disorders and Treatments
- Cholesterol and Lipid Metabolism
- Public Health Policies and Education
- Consumer Attitudes and Food Labeling
- Liver physiology and pathology
- Sarcoidosis and Beryllium Toxicity Research
- Acute Ischemic Stroke Management
- Retinal Diseases and Treatments
- Clinical practice guidelines implementation
- Pharmacy and Medical Practices
Tosei General Hospital
2023
Fujita Health University
2017-2022
Tokyo Women's Medical University
2017-2022
Fujita Health University Hospital
2019
Nagoya University Hospital
2019
Otsuka (Japan)
2017
Azabu University
2012-2016
Toho University
2016
University of Calgary
2015
Jichi Medical University Hospital
2011
The objective of this study was to evaluate the effects diet on feline stress response by measuring plasma and urinary cortisol. A developed with a unique combination nutrients that supports management stressful situations. specific formulation included alpha-casozepine, which is believed have an anxiolytic effect, tryptophan supplementation. Tryptophan precursor for synthesis neurotransmitter serotonin. Twenty-one indoor cats were fed (n = 10) or control 11) 8 weeks, after physiological...
It is important to establish experimental animal techniques that are applicable the newborn and infant phases for nutrition pharmacological studies. Breeding technology using artificial suckling method without breast milk very effective study of nutrition. Using this method, we separated mice from dams within 48 h birth provided them with milk. We evaluated mouse anxiety levels after early postnatal maternal separation. Artificially reared were subjected elevated plus-maze tests assess...
Abstract Mammalian Müller glia express transcription factors and cell cycle regulators essential for the function of retinal progenitors, indicating latent neurogenic capacity; however, role these remains unclear. To gain insights into in glia, we analyzed expression (Pax6, Vsx2 Nfia) (cyclin D1 D3) rodent focusing on their age- cycle-related patterns. Expression Pax6, Vsx2, Nfia cyclin D3, but not D1, increased during development. Photoreceptor injury induced cycle-associated increase Nfia,...
We report a case of premature chromatid separation/mosaic variegated aneuploidy syndrome identified by microcephaly on fetal ultrasound and confirmed cytogenetic analysis amniotic fluid. Initial mutational the entire coding region BUB1B gene failed to identify any causative mutations. However, further revealed known compound heterozygous mutation in upstream this novel Alu insertion intron.
A 65-year-old man with presumed choroideremia preserved central vision was examined by fundus autofluorescence (FAF) and optical coherence tomography angiography (OCTA). FAF showed an isolated area of hyperautofluorescence that involved the fovea. Although choroid capillary slab OCTA medium large choroidal vessels inferior to retinal pigment epithelium (RPE) atrophy, choriocapillaris visible in a relatively wider than hyperautofluorescent images. images allowed us detect damage RPE before...
Abstract Premature chromatid separation/mosaic variegated aneuploidy (PCS/MVA) syndrome is a rare genetic disorder. In this case report, we describe the prenatal diagnosis of PCS/MVA in 24‐year‐old, gravida 1, para woman who was referred to us her second trimester due fetal growth restriction and extreme microcephaly (−5.0 standard deviations). Amniocentesis chromosomal analysis confirmed PCS 80% cultured cells. findings were positive 9% paternal cells 11% maternal cells, indicative that...
Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by loss-of-function mutations in either of two tumor suppressor genes, TSC1 and TSC2. These lead to the growth benign tumors hamartomas many organs, including those central nervous system, skin, kidneys. To investigate genotype-phenotype correlation, we performed sequence analysis TSC1/2 genes using next-generation sequencing. We classified 30 patients with TSC whose pathogenic variants were identified into groups:...
Abstract Background Female carriers of a balanced X; autosome translocation generally undergo selective inactivation the normal X chromosome. This is because critical genes within autosomal region derivative chromosome would compromise cellular function. We here report female patient with bilateral retinoblastoma and severe intellectual disability who carries reciprocal X-autosomal translocation. Case presentation Cytogenetic molecular analyses, HUMARA (Human androgen receptor) assay,...
Abstract We herein report a novel mutation in familial progressive hyper‐ and hypopigmentation (FPHH). The KITLG gene encoding the KIT ligand protein is disease‐causing for FPHH. Various gain‐of‐function mutations, which reside within or adjacent to conserved VTNN motif of this gene, have been described date. now identified mutation, c.337G>A (p.Glu113Lys), FPHH located another ligand‐receptor interaction site.
ヘパリン起因性血小板減少症（heparin-induced thrombocytopenia；HIT）は近年本邦でも広く認知されるようになってきた．今回われわれは，シャント造設中のヘパリン投与後より出現した呼吸器症状がHIT診断の契機となった1透析症例を経験した．症例は81歳，女性．真性多血症の既往があり，糖尿病性腎症による慢性腎不全の進行のため，平成19年12月28日カテーテル挿入下に透析導入となった．9日後の内シャント造設術中のヘパリン静注直後より肺血栓塞栓症を思わせる胸痛，頻呼吸，低酸素血症が出現し，翌日には透析導入時に52.8×104/μLであった血小板数が3.2×104/μLまで著減した．画像上右内頸静脈カテーテル周囲の血栓および腎梗塞像を認めたが，肺血栓塞栓症の所見は確認されなかった．抗platelet factor...
Welcome to Annals of Global Health,Annals Health is a peer-reviewed, fully open access, online journal dedicated publishing high quality articles all aspects global health. The journal's mission advance health, promote research, and foster the prevention treatment disease worldwide. Its goals are improve health well-being people, equity, wise stewardship earth's environment. latest impact factor 3.64.Annals supported by Program for Public Common Good at Boston College. It was founded in 1934...
Objective: This study aimed to clarify the relationship between level of herniation and paraspinal muscle atrophy in patients with lumbar disc (LDH) by measuring muscles' cross-sectional area (CSA). Methods:We retrospectively analyzed data obtained from 54 LDH (level herniation; 25 L4/5, 29 L5/S1).The CSA measurements at each spinal (lower vertebral endplate L1 L5 upper S1) were determined outlining fascial boundary (i.e., multifidus, erector spinae, psoas major, quadratus lumborum).The aff...
血液透析症例におけるvascular accessの狭窄や閉塞に対して経皮的血管形成術（percutaneous transluminal angioplasty：PTA）が臨床応用されるようになり，vascular access修復の選択肢が近年拡がっている．今回われわれは，内シャント造設後に，ヘパリンにより血小板減少や血栓塞栓症がひき起こされるヘパリン起因性血小板減少症（heparin-induced thrombocytopenia：HIT）の診断に至った78歳女性の症例を経験した．シャント造設後，シャントの発達が不良であったことから，argatrobanによる抗凝固療法下にPTAを施行した．シース挿入後にargatroban 5 mgを静脈内に投与したのち，シャント近位側静脈本幹の狭窄部に対してPTAを行い，シャント血流不全の解除に成功した．治療時間は30分で，術後の経過も良好であった．ヘパリンを抗凝固療法として用いることのできないHIT症例において，内シャントPTA施行時にargatrobanが抗凝固薬として応用される可能性が示唆された．