A5102780176- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Barrier Structure and Function Studies
- Cancer-related Molecular Pathways
- Retinal Diseases and Treatments
- Immune Response and Inflammation
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Hereditary Neurological Disorders
- Advanced Fluorescence Microscopy Techniques
- Neurosurgical Procedures and Complications
- DNA Repair Mechanisms
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- bioluminescence and chemiluminescence research
- Hippo pathway signaling and YAP/TAZ
- Photochromic and Fluorescence Chemistry
Tokyo Women's Medical University
2007-2024
University Health Network
2005
Canada Research Chairs
2003
University of Toronto
2002-2003
Centre for Addiction and Mental Health
2002-2003
Tokyo Medical and Dental University
1994-1999
Color vision is supported by retinal cone photoreceptors that, in most mammals, express two photopigments sensitive to short (S-opsin) or middle (M-opsin) wavelengths. Expression of the Opn1sw and Opn1mw genes, encoding S-opsin M-opsin, respectively, under control nuclear receptors, including thyroid hormone receptor beta2 (TRbeta2), retinoid X gamma (RXRgamma), RORbeta, a member retinoic acid receptor-related orphan (ROR) family. We now demonstrate that RORalpha, another ROR family,...
The fate of neutrophils in the peripheral circulation is poorly understood. In this study, role Kupffer cells eliminating aged and apoptotic was investigated. Liver, spleen, lung, blood samples from Wistar rats were examined by light electron microscopy, terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate–biotin nick end labeling (TUNEL) method, immunohistochemistry after intravenous injection OK–432, a streptococcal preparation. Neutrophils trapped predominantly...
Müller glia, the principal glial cell type in retina, have potential to reenter cycle after retinal injury. In mammals, proliferation of glia is followed by gliosis, but not regeneration neurons. Retinal injury also accompanied phagocytic removal degenerated cells. We here investigated possibility that and gliosis phagocytosis cells may be regulated same molecular pathways. After N-methyl-N-nitrosourea-induced injury, photoreceptors were eliminated prior infiltration microglia/macrophages...
Purpose: Müller glia, the principal glial cell type in retina, have potential to proliferate and regenerate neurons after retinal damage. However, unlike situation fish birds, this capacity of glia is extremely limited mammals. To gain new insights into mechanisms that hamper regeneration mammals, we examined cycle progression DNA damage response Methods: Expression cycle-related proteins were analyzed adult rat mouse retinas N-methyl-N-nitrosourea (MNU)- or N-methyl-D-aspartate...
Abstract Rapid saltatory nerve conduction is facilitated by myelin structure, which produced Schwann cells (SC) in the peripheral nervous system (PNS). Proper development and degeneration/regeneration after injury requires regulated phenotypic changes of SC. We have previously shown that glutamate can induce SC proliferation culture. Here we show signals through metabotropic receptor 2 (mGluR2) to Erk phosphorylation mGluR2-elicited ErbB2/3 tyrosine kinase limit signaling cascade promotes...
Abstract Mammalian Müller glia express transcription factors and cell cycle regulators essential for the function of retinal progenitors, indicating latent neurogenic capacity; however, role these remains unclear. To gain insights into in glia, we analyzed expression (Pax6, Vsx2 Nfia) (cyclin D1 D3) rodent focusing on their age- cycle-related patterns. Expression Pax6, Vsx2, Nfia cyclin D3, but not D1, increased during development. Photoreceptor injury induced cycle-associated increase Nfia,...
Abstract Animal models for retinal degeneration are essential elucidating its pathogenesis and developing new therapeutic strategies in humans. N -methyl- -nitrosourea (MNU) has been extensively used to construct a photoreceptor-specific model, which served unveil the molecular process of photoreceptor as well mechanisms regulating protective responses remaining cells. Methyl methanesulphonate (MMS), also known cause degeneration, is considered good alternative MNU due higher usability;...
Cyclin-dependent kinase (CDK) inhibitors play an important role in regulating cell cycle progression, exit and differentiation. p27KIP1 (p27), one of the major CDK retina, has been shown to control timing retinal progenitors. However, precise this protein development remains largely unexplored. We thus analyzed p27-deficient mice characterize effects p27 loss on proliferation, differentiation, survival cells.Expression developing mature mouse retina was by immunohistochemistry using...
This report presents a case of deep peroneal nerve palsy caused by an injury during drilling for distal locking screws T-shaped plate used osteosynthesis medial open-wedge high tibial osteotomy. A cadaveric simulation study reproduced the risk surgery.
Abstract Retinal Müller glia have a capacity to regenerate neurons in lower vertebrates like zebrafish, but such ability is extremely limited mammals. In proliferate after injury, which promotes their neurogenic reprogramming while inhibiting reactive gliosis. mammals, however, how the cell cycle affects fate of injury remains unclear. Here, we focused on expression proneural transcription factors, Ngn2 and Ascl1, gliosis marker glial fibrillary acidic protein (GFAP) rat N -methyl-...
Abstract Animal models for retinal degeneration are essential elucidating its pathogenesis and developing new therapeutic strategies in humans. N-methyl-N-nitrosourea (MNU) has been extensively used to construct a photoreceptor-specific model, which served unveil the molecular process of photoreceptor as well mechanisms regulating protective responses remaining cells. Methyl methanesulphonate (MMS), also known cause degeneration, is considered good alternative MNU due higher usability;...