A5014900608- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Diet and metabolism studies
- Tryptophan and brain disorders
- Growth Hormone and Insulin-like Growth Factors
- Eating Disorders and Behaviors
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Nitric Oxide and Endothelin Effects
- Spaceflight effects on biology
- Birth, Development, and Health
- Dietary Effects on Health
- Treatment of Major Depression
- Hypothalamic control of reproductive hormones
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Schizophrenia research and treatment
- Pituitary Gland Disorders and Treatments
- Bipolar Disorder and Treatment
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Adrenal Hormones and Disorders
University of Toronto
2014-2024
Centre for Addiction and Mental Health
2014-2024
Case Western Reserve University
2023
Auburn University
2023
Pontificia Universidad Católica Argentina
2022
Nipissing University
2022
Addiction Research Foundation
2018
The University of Queensland
2016
University of Liechtenstein
2010
McMaster University Medical Centre
1979-2009
Cognitive studies of memory processes demonstrate that for stimuli is a function how they are encoded; processed semantically better remembered than those in perceptual or shallow fashion. This study investigates the neural correlates this cognitive phenomenon. Twelve subjects performed two different tasks on series visually presented nouns. In one task, detected presence absence letter a; other, categorized each noun as living nonliving. Positron emission tomography (PET) scans using...
Clonidine (0.15 mg iv), a selective noradrenergic receptor agonist, increased serum growth hormone (GH) levels (greater than 6 ng/ml) on 8 out of 12 administrations to normal men. This increase was independent the hypotensive effects drug and unrelated changes in cortisol. induced hyperglycemic effect all subjects which greatest 15 min after commencint injection. No blood sugar or GH occurred placebo Apomorphine, dopamine elevated each these 10 ng/ml). had no prolactin (PRL), luteinizing...
Retrieval of information from episodic memory involves the processes invoked by attempt to remember (retrieval attempt) as well associated with successful retrieval stored (ecphory). Previous PET studies have shown an activation prefrontal cortex in tasks, and we hypothesised that this represents retreival attempt, not ecphory. This hypothesis was directly directed using [15O]H2 imaging 19 healthy subjects who performed three matched tasks which involved different levels The results showed...
OBJECTIVE: Dysfunctional attitudes are negatively biased assumptions and beliefs regarding oneself, the world, future. In healthy subjects, increasing serotonin (5-HT) agonism with a single dose of d-fenfluramine lowered dysfunctional attitudes. To investigate whether converse, low level 5-HT agonism, could account for higher levels observed in patients major depression or self-injurious behavior, cortex 5-HT2 receptor binding potential were measured depressive disorder, history comparison...
OBJECTIVE: In the cortex of animals, serotonin (5-HT) levels increase after several weeks treatment with selective reuptake inhibitors (SSRIs). Studies using an intrasubject design to examine effects SSRI on 5-HT2A receptors in drug-free depressed patients are needed. theory, agonist stimulation could be relevant by promoting neuronal growth and survival as well direct elevation mood. The objective this study was evaluate effect 6 paroxetine patients. METHOD: After a medication-free period...
Corticosterone, prolactin, and growth hormone responses to 5 s of handling or 3 min novel environment were compared in rats at crest trough the diurnal adrenal rhythm 0,5, 15, 30, 60 after stimulation. All hormones responded stimulation, corticosterone prolactin with a dramatic rise, precipitous fall. Resting levels evidenced expected variation, but not also showed baseline variation small magnitude times studied. Growth response characteristics unaffected by time day type Both profiles...
In order to determine whether the basal hypothalamus or pituitary (or both) is likely locus of action tuberoinfundibular (TI) dopamine neurons, these regions were examined for and neuroleptic receptors. High affinity receptors haloperidol found in rat while none detected hypothalamus. The relative ability two neuroleptics, chlorpromazine haloperidol, displace (3H)haloperidol from receptor monkey similar that striatum. lack capable binding (3H)dopamine strongly suggests TI neurons do not...
The circadian rhythm of melatonin in saliva or plasma, the metabolite 6-sulfatoxymelatonin (a6MTs) urine, is a defining feature suprachiasmatic nucleus (SCN) function, body's endogenous oscillatory pacemaker. primary objective this review to ascertain clinical benefits and limitations current methodologies employed for detection quantification biological fluids tissues.A search English-language literature (Medline) systematic published articles were carried out.Articles that specified both...
Temporal characteristics of hormonal responses to handling and novel environment were studied in the rat order determine whether same factors which modify corticosterone responses, i.e., time day type stimulus, also prolactin GH responses. Resting showed expected difference between crest trough diurnal cycle. In contrast, no at these times. Prolactin elevation occurred response stimuli produced adrenal activation. however, differed from being more rapid cycle slower crest. contrast...
Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology depression. Of 5-HT receptor abnormalities reported, most replicated finding is increased 5-HT2 binding postmortem prefrontal cortex depressed suicide victims. The extent to which these findings exist persons without recent attempts uncertain. objective this study was evaluate receptors patients who were medication-free and had not made attempts.With use [18F]setoperone positron emission tomography (PET),...
Objective The effects of exogenous melatonin on sleep, daytime sleepiness, fatigue, and alertness were investigated in 22 patients with delayed sleep phase syndrome whose nocturnal was restricted to the interval from 24:00 08:00 hours. This study a randomized, double-blind, placebo-controlled crossover trial. Subjects received either placebo or (5 mg) daily for 4 weeks, underwent 1-week washout period, then given other treatment an additional weeks. Patients could take between 19:00 21:00...