A5103084382- Sleep and Wakefulness Research
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- Restless Legs Syndrome Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Asthma and respiratory diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Child Nutrition and Feeding Issues
- Body Composition Measurement Techniques
- Early Childhood Education and Development
- Sports Performance and Training
- Glaucoma and retinal disorders
- Obesity, Physical Activity, Diet
- Childhood Cancer Survivors' Quality of Life
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Syndromes and Imprinting
- Thermoregulation and physiological responses
University of Toronto
2014-2024
Toronto Western Hospital
2008-2023
Child, Adolescent and Family Mental Health
2012-2022
Toronto Sleep Institute
2009-2022
Ontario Centre of Excellence for Child and Youth Mental Health
2011-2020
University Health Network
2009-2019
Canadian Sleep & Circadian Network
2019
Western Research Institute
2007
University of Waterloo
2007
Scripps Research Institute
2000
Abstract Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that evoked detailed autobiographical memories. Associative memory tasks conducted in double‐blinded “on” versus “off” manner demonstrated increased recollection but not familiarity‐based recognition, indicating functional engagement of the hippocampus. Electroencephalographic source localization showed drove activity mesial temporal lobe structures....
We have observed patients who clinically the obstructive sleep apnea syndrome but no apneas, instead having recurrent nocturnal hypoventilation. There is disagreement about definition and significance of such sleep-related hypopneas. thus analyzed breathing patterns, oxygenation records 50 consecutive referred with clinical features found to abnormal during determine: (1) best hypopnea, (2) how frequently without apneas. Hypopnea definitions based on decreases in thoracoabdominal movement...
Objective Solriamfetol (JZP‐110) is a selective dopamine and norepinephrine reuptake inhibitor with wake‐promoting effects. This phase 3 study (NCT02348593) evaluated the safety efficacy of solriamfetol in narcolepsy. Methods Patients narcolepsy mean sleep latency <25 minutes on Maintenance Wakefulness Test (MWT), Epworth Sleepiness Scale (ESS) score ≥10, usual nightly ≥6 hours were randomized to 75, 150, or 300 mg, placebo for 12 weeks. Coprimary endpoints change from baseline week MWT...
Heart rate variability was measured in 77 healthy controls and 343 diabetic patients by a count of the number beat-to-beat differences greater than 50 ms RR interval during 24 hour ambulatory electrocardiogram. In lower 95% tolerance limits for total counts were approximately 2000 at age 25, 1000 45, 500 65 years. Six confined to bed after injury had normal patterns counts, while eight other showed loss diurnal variation both heart period sleep deprivation. ten on off night duty increased...
SUMMARY The behavioural effects of varying the replacement dose oral androgen testosterone undecanoate (TU, Restandol) were investigated in eight hypogonadal men. Each man was withdrawn from his previous regimen and after a period no treatment administered four doses TU (40, 80, 120 160 mg/d) successive one‐month periods using double‐blind design. Throughout study each recorded sexual interest, behaviour mood state daily diary form. In addition, subjects had sleep erections quality assessed...
We measured ear oxygen saturation (SaO2), chest wall movement, and oronasal air flow, took electroencephalographic tracings during nocturnal sleep in 20 healthy subjects similarly aged patients with chronic obstructive pulmonary disease (COPD), none of whom was obese. Thirteen the COPD were persistently hypoxemic hypercapnic when awake ("blue bloated", Type B); remaining 7 maintained relatively normal arterial gas tensions despite equally severe airways obstruction ("pink puffing", A)....
Abstract Background: Anesthetics, analgesics, and surgery may profoundly affect sleep architecture aggravate sleep-related breathing disturbances. The authors hypothesized that patients with preoperative polysomnographic evidence of obstructive apnea (OSA) would experience greater changes in these parameters than without OSA. Methods: After obtaining approvals from the Institutional Review Boards, consented underwent portable polysomnography preoperatively on postoperative nights (N) 1, 3,...
The knowledge on the mechanism of postoperative exacerbation sleep-disordered breathing may direct perioperative management patients with obstructive sleep apnea. objective this study is to investigate factors associated severity breathing.After obtaining approvals from Institutional Review Boards, consenting underwent portable polysomnography preoperatively, and nights 1 3 in hospital or at home. primary outcomes were parameters measuring breathing. They treated as repeated measurement...
Sleep recordings were carried out on athletes four successive nights after completing a 92-kilometer road race. Significant increases in total sleep time and slow-wave found this metabolic stress. The results show definite exercise effect support sleep-restoration hypotheses.
We conducted a longitudinal polysomnographic study in five healthy primiparous subjects, whose sleep was first recorded between 8 and 16 weeks of gestation, then every 2 months until parturition at 1 month postpartum. The 6 hours were used for statistical analysis. In contrast to previous studies, we found no reduction stage 4 with pregnancy. Slow-wave (comprising stages 3 4), significantly higher 27-39 gestation than 8-16 weeks, as predicted by the restorative theory sleep. There...
Objective The effects of exogenous melatonin on sleep, daytime sleepiness, fatigue, and alertness were investigated in 22 patients with delayed sleep phase syndrome whose nocturnal was restricted to the interval from 24:00 08:00 hours. This study a randomized, double-blind, placebo-controlled crossover trial. Subjects received either placebo or (5 mg) daily for 4 weeks, underwent 1-week washout period, then given other treatment an additional weeks. Patients could take between 19:00 21:00...
Most patients with asthma waken nocturnal from time to time. To assess morbidity in sleep quality, daytime sleepiness, and cognitive performance were measured prospectively 12 (median age 43 years) intellect matched normal subjects. The median (range) percentage overnight fall peak expiratory flow rate (PEF) was 22 (15 50) the 4 (-4 7) had poorer average scores for subjective quality than subjects paired difference 1.1 (95% confidence limits 0.1, 2.3)). Objective also worse asthmatic...
The role of drug therapy in the treatment sleep apnea/hypopnea syndrome is unclear. In a randomised, double-blind, placebocontrolled study, we investigated value 14-day with protriptyline (20 mg daily) or acetazolamide (250 4 times per day) on symptoms and frequency apneas, hypopneas, arousals, 4% de saturations 10 patients obstructive syndrome. Overall, did not have significant effect either any above polysomnographic criteria. Acetazolamide reduced [placebo 50 ± 26 (SD); 20/h sleep, p <...
Changes in the density of eye movement during rapid (REM) sleep are associated with changes ventilation and ventilatory response animals. Recent data patients chronic obstructive pulmonary disease suggest that periods frequent movements may be hypoxemia REM sleep. We have therefore investigated association between pattern 10 normal men. Expired was measured using a pneumotachograph attached to valved face mask dead space 50 ml incorporating peripheral CO2 leak detector. Ventilation reduced...