A5072054080- Growth Hormone and Insulin-like Growth Factors
- Neuropeptides and Animal Physiology
- Genetic Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Pituitary Gland Disorders and Treatments
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroendocrine Tumor Research Advances
- Hypothalamic control of reproductive hormones
- Thyroid Disorders and Treatments
- Neurology and Historical Studies
- Neuroscience of respiration and sleep
- Amino Acid Enzymes and Metabolism
- Health and Medical Research Impacts
- Neurological diseases and metabolism
- Diet and metabolism studies
- Biomedical Research and Pathophysiology
- Neurotransmitter Receptor Influence on Behavior
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
John Peter Smith Hospital
2023
Harvard University
2004-2020
University of Toronto
1974-2017
McGill University
1974-2015
Montreal General Hospital
1972-2015
Bradford Royal Infirmary
2015
St. Luke's Medical Center
2015
Tufts Medical Center
2015
Icahn School of Medicine at Mount Sinai
2014
Harvard University Press
1996-2001
Sequential blood samples were obtained from undisturbed freely-behaving male rats bearing chronic intracardiac venous cannulae. Blood was withdrawn every 15 min for periods of 4-24 h; plasma separated, and saline-resuspended red cells reinjected. Plasma GH determined by radioimmunoassay. Pulsatile secretion evident in each animal with most peak values greater than 200 ng/ml trough less ng/ml. The secretory episodes occurred at approximately 3 h intervals, this rhythmic pattern persisted...
EXERCISE training is used increasingly to prevent and treat disease, millions of healthy persons participate in strenuous sports; yet, the mechanisms by which exercise produces various clinical effects are imperfectly understood. Emerging evidence suggests that endogenous opioid peptides influence diverse functions linked with body's energy balance, including appetite,1 thermorégulation,2 lipolysis,3 reproduction.4 Preliminary observations athletes indicate acute expenditure during...
Clonidine (0.15 mg iv), a selective noradrenergic receptor agonist, increased serum growth hormone (GH) levels (greater than 6 ng/ml) on 8 out of 12 administrations to normal men. This increase was independent the hypotensive effects drug and unrelated changes in cortisol. induced hyperglycemic effect all subjects which greatest 15 min after commencint injection. No blood sugar or GH occurred placebo Apomorphine, dopamine elevated each these 10 ng/ml). had no prolactin (PRL), luteinizing...
We have previously found that a biochemically distinct subset of neurons, containing nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), is selectively resistant to the degenerative process affects striatum in Huntington's disease (HD). report morphologic and histochemical characteristics these striatal neurons their distribution with respect compartments as defined by acetylcholinesterase (AChE) activity. Sections were stained histochemically for NADPH-d AChE...
Somatostatin receptor concentrations were measured in patients with Alzheimer's disease and controls. In the frontal cortex (Brodmann areas 6, 9, 10) temporal area 21), of somatostatin receptors reduced to approximately 50 percent control values. A 40 reduction was seen hippocampus, while no significant changes found cingulate cortex, postcentral gyrus, pole, superior gyrus. Scatchard analysis showed a number rather than change affinity. Somatostatin-like immunoreactivity significantly both...
Young adult cyclic female rats were each injected with 2 mg estradiol valerate (EV) in sesame oil. Controls received an equivalent volume of Within months after injection, most the EV-treated animals showed persistent vaginal estrus and small polyfollicular ovaries as well pathological changes hypothalamic arcuate nucleus. This process was gradually progressive such that by 6 EV basal lateral region nucleus contained numerous reactive microglia, astrocytes, degenerating elements neuropil....
Somatostatin receptors in rat brain, pituitary, and pancreas were labeled with two radioiodinated analogs of somatostatins 14 28. Two cyclic somatostatin, SMS201-995 cyclo(Ala-Cys-Phe-D-Trp-Lys-Thr-Cys), showed biphasic displacement binding to somatostatin by these radioligands. In contrast, all other analogs, including somatostatin-14, competed for the receptor sites monophasic radioligand binding. Thus types identified. It was found that pituitary have predominantly one type whereas brain...
Clinical records were evaluated for 163 Huntington9s disease patients in whom postmortem brain specimens had been graded degree of neuropathologic involvement the striatum. Juvenile/adolescent onset (4 to 19 years age) was associated with very severe produced by an apparent rapid degenerative process. Cases early (20 34 years) and midlife (35 49 respectively less striatal involvement, suggesting a slower progression. High correlations among grade cell counts neurons, rating physical...
Immunoreactive calcitonin (CT), indistinguishable from human CT-(1-32) and its sulfoxide, has been identified in extracts of the hypothalamus, pituitary, thyroid obtained subjects at autopsy. DCT concentrations were highest a region encompassing posterior median eminence, pituitary; intermediate substantia nigra, anterior globus pallidus, inferior colliculus; low caudate nucleus, hippocampus, amygdala, cerebral cerebellar cortices. Specific CT binding measured with 125I-labeled salmon was...
Adult rats which have received monosodium-L-glutamate (MSG) (4 mg/g body weight) on alternate days for the first ten of life acquire neurotoxic lesions retina and arcuate nucleus manifest an endocrine deficiency syndrome characterized by stunted growth, obesity, hypothyroidism, hypogonadism pituitary atrophy. In present study, biochemical basis MSG-induced dysfunction has been examined findings note are as follows: normal serum levels TSH LH despite hypothyroidism gonadal atrophy,...
Huntington disease (HD) is an autosomal dominant hereditary disorder characterized by premature cell death, predominantly in the neostriatum. Decreased concentrations of several neurotransmitters and neuropeptides have been reported basal ganglia disease. We now report that radioimmunoassayable somatostatin are increased extracts caudate (mean +/- standard error mean, ng/gm net weight; 247 24 versus 85 11), putamen (275 48 74 external globus pallidus (100 10 27 6), internal (108 21 8) The...
The probability of carrying the gene for Huntington's disease can in many cases be estimated children affected persons by identifying a specific DNA marker that is genetically linked to gene. We studied 47 at 50 percent risk inheriting who requested presymptomatic or prenatal genetic-linkage test between September 1986 and January 1988. participants were given pre-test counseling psychological neurologic evaluations. Nineteen later voluntarily withdrew from protocol, including one would have...
Plasma growth hormone levels fall and remain low for several hours after stress in the rat. When antiserums to somatostatin are administered rats prior stress, secretory pulses partially restored. The results provide evidence that circulating plays a prominent role stress-induced inhibition of secretion
The role of SRIF in starvation-induced inhibition GH and insulin secretion was assessed by passive immunization with anti-SRIF serum. Six-hour secretory profiles obtained from chronically cannulated male rats deprived food for 72 h showed marked suppression bursts significant depression plasma levels. Administration 1 ml antiserum (SRIF AS) iv to starved resulted rapid (within 15 min) restoration high amplitude pulses (600-800 ng/ml) sighificant elevation trough values. mean 6-h level SRIF,...