The rate of disease progression was assessed for 42 persons affected by Huntington's who had been neurologically examined at least six times and followed up 3 years. Disease a disability rating scale administered each examination. Slow associated with older age onset heavier weight (body mass index) the first Men tended to have slower than did women, this particularly evident among men inheriting from mothers. Neither butyrophenone haloperidol nor tricyclic antidepressant imipramine were...

<h3>Importance</h3> Depression and anxiety are associated with adverse cardiovascular outcomes in patients recent acute cardiac events. There has been minimal study of collaborative care (CC) management models for mental health disorders high-risk inpatients, no prior CC intervention simultaneously managed depression disorders. <h3>Objective</h3> To determine the impact a low-intensity depression, generalized disorder, panic disorder among hospitalized an illness. <h3>Design, Setting,...

The probability of carrying the gene for Huntington's disease can in many cases be estimated children affected persons by identifying a specific DNA marker that is genetically linked to gene. We studied 47 at 50 percent risk inheriting who requested presymptomatic or prenatal genetic-linkage test between September 1986 and January 1988. participants were given pre-test counseling psychological neurologic evaluations. Nineteen later voluntarily withdrew from protocol, including one would have...

The management of depression and other negative psychological states in cardiac patients has been a focus multiple treatment trials, though such trials have not led to substantial improvements outcomes. In contrast, there minimal on interventions increase positive patients, despite the fact that optimism associated with superior cardiovascular Our objective was develop an 8-week, phone-based psychology intervention for hospitalized acute disease (acute coronary syndrome or decompensated...

Abstract One hundred thirty‐one individuals at 50% risk of inheriting Huntington disease (HD) responded to a survey study their attitudes toward taking genetic test based on the identification genetically linked DNA polymorphism. Ninety‐six percent respondents believe that presymptomatic testing should be available, and 66% say they will use it themselves. Fewer married individuals, in comparison those single, separated, divorced, intend take test. Many (40%) said primary reason for wanting...

Background— Depression is independently associated with poor outcomes among patients acute cardiac disease. Collaborative care depression management programs have been used in outpatients to improve outcomes, but such a program had never initiated the hospital or for wide range of illnesses. Methods and Results— This was prospective, randomized trial low-intensity, 12-week collaborative versus usual 175 depressed hospitalized coronary syndrome, arrhythmia, heart failure. Study assessed using...

Background Positive psychological constructs have been associated with reduced suicidal ideation, and interventions to cultivate positive feelings the potential reduce suicide risk. This study compares efficacy of a 6-week, telephone-based psychology (PP) intervention against cognition-focused (CF) control among patients recently hospitalized for depression ideation or behavior. Method A total 65 adults current major depressive episode reporting recent attempt were enrolled from...

ABSTRACT Objective Despite the clear benefits of physical activity and related behaviors on prognosis, most patients experiencing an acute coronary syndrome (ACS) remain nonadherent to these behaviors. Deficits in positive psychological constructs (e.g., optimism) are linked reduced participation health behaviors, supporting potential utility a psychology (PP)-based intervention post-ACS patients. Accordingly, we aimed identify optimal components PP-based promote activity. Methods As part...

The aim of this study was to determine the prevalence psychiatric symptoms among nondemented individuals with memory changes and whether such predict progression functional decline or diagnosis Alzheimer disease (AD). A semi-structured interview administered at baseline controls (n = 32) subjects 112) each subject's collateral source. assessed impact cognition on abilities in daily life a variety symptoms, including psychosis, depression, personality change. Participants were followed...

Depression and anxiety in patients with cardiac disease are common independently associated morbidity mortality. We aimed to explore the use of a 3-step approach identify inpatients depression, generalized disorder (GAD), or panic disorder; understand predictive value individual screening items identifying these disorders; assess relative prevalence disorders this cohort.To depression as part care management trial, an iterative procedure was used. This included existing 4-item (Coping...

By understanding common motivations for participating in observational research studies, clinicians may better understand the perceived benefits of participation from their clients' perspective. We enrolled 164 cardiac patients a study about effects gratitude and optimism. Two weeks post-enrollment, participants completed four-item questionnaire regarding enrollment. Altruistic motivation ranked highest, while intellectual, health-related, financial rated lower. Four subgroups emerged, each...

Positive psychological states are linked to superior cardiac outcomes, possibly mediated through increased participation in health behaviors. Trained study staff conducted in-depth semi-structured interviews the hospital and 3 months later for 34 patients diagnosed with an acute coronary syndrome. These focused on positive states, behaviors, their connection; were transcribed independently coded using directed content analysis. Both optimism affect associated completion of physical activity...

Asymptomatic persons at risk for Huntington's disease (HD) (N = 28) were assessed with neuropsychological, psychiatric, and neurologic tests while undergoing genetic linkage studies to determine their probability of carrying the HD gene. Those participants who subsequently identified as probable gene carriers did not differ on or psychiatric examination from those noncarriers. Neuropsychological data are presented a subset free other conditions (such alcoholism) putting them cognitive...

Abstract The predictive test for Huntington disease (HD) has allowed those at risk to determine gene status prior symptoms. purpose of this research was understand the motivation and anticipated reactions requesting test. Forty persons 50% HD 31 companions participated in a structured personal interview as part protocol. Reasons taking centered on reduction anxiety uncertainty associated with being enhanced planning decision making. Participants also believed that would produce more positive...

Background: There are few effective treatments for bipolar depression, a common and debilitating illness.Aims: We aimed to examine the feasibility preliminary efficacy of four-week, telephone-delivered positive psychology (PP) intervention patients with depression.Methods: Twenty-five hospitalized depression were randomized receive PP (n = 14) or control condition (CC; n 11) intervention. Following discharge, participants completed weekly exercises phone calls study trainer. was assessed by...

Background: Positive psychological constructs, such as optimism, are associated with greater participation in cardiac health behaviors and improved outcomes. psychology interventions, which target well-being, may represent a promising approach to improving high-risk patients. However, no study has assessed whether positive intervention can promote physical activity following an acute coronary syndrome. Objective: In this article we will describe the methods of novel factorial design aid...

To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization.Data were analyzed from 137 depressed patients hospitalized on inpatient units for acute coronary syndrome, decompensated heart failure, or arrhythmia who enrolled a randomized trial collaborative care management. Subjects' demographic, medical, psychiatric information at was compiled. Measures health-related quality life, symptoms, including...