A5102729265- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Remote Sensing in Agriculture
- Remote Sensing and Land Use
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Gastroesophageal reflux and treatments
- Respiratory Support and Mechanisms
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Helicobacter pylori-related gastroenterology studies
- Neurotransmitter Receptor Influence on Behavior
- Urban Heat Island Mitigation
- High Altitude and Hypoxia
- Environmental Changes in China
- Remote Sensing and LiDAR Applications
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Primate Behavior and Ecology
- Photoreceptor and optogenetics research
Tokyo Metropolitan Institute of Medical Science
2013-2024
Tokyo Women's Medical University
2009-2024
Tokyo Metropolitan Police Department
2009-2023
Toho University
2008-2021
Chiba University
1998-2021
Toho University Omori Medical Center
2008-2020
University of Tsukuba
2003-2017
Fumakilla (Japan)
2017
University Medical Center
2016
University Hospital and Clinics
2016
Abstract The cytotoxicity of NK cells has been thought to be mediated mainly by the perforin-dependent pathway. We investigated involvement Fas-mediated pathway in killing activity purified human CD3-, CD16+ cells. Fas ligand mRNA was expressed freshly isolated Apoptosis, which identified fragmented chromatin individual cells, induced that high levels via direct NK-to-target cell interaction or Ab-dependent cell-mediated cytotoxicity, even Ca(2+)-free medium, perforin pores are known not...
Aim Although the prevalence of H elicobacter pylori ( . ) increases with age and main period acquisition is childhood, route transmission infection remains unclear. This study aims to evaluate relationship between children grandparents. Methods A total 838 consecutive who attended Urita clinic whose blood was taken for work up were enrolled in present study. They 449 boys 389 girls, a mean 12.4 years. serology their family members living together one house picked analyse intra‐familial...
Methylphenidate (MPH; trade name Ritalin) is a widely used drug for the treatment of attention deficit hyperactivity disorder (ADHD) and often as cognitive enhancer. Because MPH increases dopamine (DA) release by blocking DA transporter in human striatum, supposed to work on cognition through increase striatum. However, ADHD patients show impaired prefrontal cortex (PFC) function administration associated with increased neural activity PFC. Although indicated rat PFC, there has been no study...
The sulfhydryl reagent thimerosal enhanced the sensitivity of hamster eggs to injected inositol 1,4,5‐trisphosphate (InsP 3 ) or Ca 2+ generate regenerative release from intracellular pools. A monoclonal antibody (mAb) InsP receptor blocked both ‐induced (IICR) and (CICR). mAb also oscillations induced by thimerosal. results indicate that enhances IICR sensitized cytosolic , but not CICR ‐insensitive pools, causes repetitive releases ‐sensitive
Abstract The organization of the laminar and topographical projections from presubiculum to entorhinal area was studied in rat by anterograde labeling with Phaseolus vulgaris leucoagglutinin retrograde horseradish peroxidase conjugated wheat germ agglutinin. We found that pattern presubiculo‐entorhinal differs between superficial deep layers presubiculum. (layers II III) gave rise bilateral I–VI medial (MEA). Many terminals were distributed layer III, fewer portion I, many V VI) MEA. In...
Abstract Global hypomethylation is frequently reported in immune-mediated diseases; however, its extent and underlying mechanisms are largely unknown. By examining seven diseases, we found that most exhibited global hypomethylation, particularly at CpGs the solo-WCGW context — sequences lacking neighboring (W = A/T) which prone to passive demethylation during cell division. The hypomethylated were predominantly located transcriptionally repressed regions, potentially reflecting increased...
We investigated responses of respiration, blood pressure, and heart rate to tracheal mucosa irritation induced by injection distilled water at three different levels CO2 ventilatory drive in 11 spontaneously breathing female patients under a constant depth enflurane anesthesia [1.1 minimum alveolar concentration (MAC)]. The airway the resting level spontaneous caused variety respiratory such as coughing, expiration reflex, apnea, spasmodic panting, with considerable increases pressure rate....
The results of aeromagnetic observations at Izu-Oshima, Japan using an unmanned autonomous helicopter are reported. A practical observation system was assembled, adopting a bird-type magnetometer installation, and dense the northern half caldera area including central cone were made from very low altitude. In detailed magnetization intensity mapping deduced collected data, vent three rows high on floor found. former is interpreted as presence high-temperature materials, such magma or hot...
The presubiculum is one of the important regions parahippocampal area known to be responsible for processing and integrating spatial representation information. To understand better functional roles played by presubiculum, it essential elucidate how output signals from distribute its target regions. In present study, axonal branching patterns single pyramidal neurons in layer V rat were investigated using vivo injection a viral vector expressing membrane-targeted palmitoylation site-attached...
Frankincense essential oil, obtained from Boswellia carteri, is a popular which widely used in many parts of the world. While some its properties are known, effects on stress and sleep have not been studied. The frankincense oil major components, limonene α-pinene, plasma corticosterone glutathione (GSH) levels, as well wakefulness behaviour, were studied sleep-deprived rats. substances applied topically after dilution jojoba (vehicle). As compared to vehicle, at 1/1000 (1:103) significantly...
BACKGROUNDSince high-quality evidence on conservative treatment of acute appendicitis using antibiotics has increased, differentiation patients with complicated (CA) from those simple (SA) become increasingly important.Previous studies have revealed that male gender, advanced age, comorbid conditions, prehospital delay, fever, and anorexia are risk factors perforated appendicitis.Elevated serum C-reactive protein (CRP) level hyponatremia also been reported as predictive biomarkers...
Honda, Y., H. Tani, A. Masuda, T. Kobayashi, Nishino, Kimura, S. Masuyama, and Kuriyama. Effect of prior O 2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans. J. Appl. Physiol. 81(4): 1627–1632, 1996.—Sixteen healthy volunteers breathed 100% or room air for 10 min random order, then their normocapnic (80% arterial saturation, as measured with a pulse oximeter) was studied 20 min. In addition, detect agents possibly responsible the respiratory changes, blood...
Breathing pattern and steady-state CO2 ventilatory response during mouth breathing were compared with those nose in nine healthy adults. In addition, the effect of warming humidification inspired air on was observed through a mouthpiece. We found following. 1) Dead space airway resistance significantly greater than breathing. 2) The slope responses did not differ appreciably two types breathing, but occlusion pressure enhanced 3) Inhalation warm humid mouthpiece depressed ventilation...
Abstract The anterior thalamic nuclei consist of the anterodorsal (AD), anteroventral, and anteromedial nuclei, each which are highly differentiated may contribute to different aspects various cognitive memory functions. In particular, AD is unique in that it implicated learning at earliest stage discriminative avoidance conditioning rabbit. To better understand functional roles played by processes, we analyzed organization thalamocortical projections rabbit, using anterograde tracer...