A5049208277- IgG4-Related and Inflammatory Diseases
- Ocular Oncology and Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Soft tissue tumor case studies
- Vascular Malformations and Hemangiomas
- Cutaneous Melanoma Detection and Management
- CNS Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Vascular Tumors and Angiosarcomas
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Otitis Media and Relapsing Polychondritis
- Histiocytic Disorders and Treatments
- Viral-associated cancers and disorders
- Metastasis and carcinoma case studies
- Sinusitis and nasal conditions
- Neuroendocrine Tumor Research Advances
- Ear and Head Tumors
- Breast Lesions and Carcinomas
- Myasthenia Gravis and Thymoma
- Body Image and Dysmorphia Studies
- Cytomegalovirus and herpesvirus research
- Meningioma and schwannoma management
- Analytic Number Theory Research
Nagoya Medical Center
2012-2024
National Hospital Organization
2011-2024
Higashi Nagoya National Hospital
2003
Saiseikai Central Hospital
1998
Nagoya University
1997
<h3>Objective</h3> To determine the clinicopathological characteristics of patients with infiltration IgG4-positive plasma cells into ocular adnexa. <h3>Methods</h3> We designed a prospective study to evaluate 24 adnexal lymphoplasmacytic infiltrative lesions, including sclerosing inflammation and reactive lymphoid hyperplasia. analyzed peripheral blood biopsy specimens from all patients. The classification criteria for placement in IgG4-related group included having both an elevated serum...
Orbital IgG4-related disease, which can occur in adults of any age, is characterized by IgG4-positive lymphoplasmacytic infiltrations ocular adnexal tissues. The signs and symptoms include chronic noninflammatory lid swelling proptosis. Patients often have a history allergic disease elevated serum levels IgG4 IgE as well hypergammaglobulinemia. must be differentiated from idiopathic orbital inflammation marginal zone B-cell lymphoma to ensure appropriate effective treatment. Systemic steroid...
To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) IgG4-positive plasma cells.114 biopsy samples MZBLs were analysed. cells included when IgG4:IgG ratio was >40% (IgG4-related group). The serum levels each subclass immunoglobulins and soluble interleukin-2 receptor in IgG4-related group compared those 61 consecutive having MZBL without (IgG4-unrelated They also 10 lymphoplasmacytic disorder inflammatory group).Ten (9%)...
Granular cell tumors are uncommon, usually benign of Schwann origin. The malignant variant is extremely rare, representing <2% all granular tumors. Therefore, standard systemic chemotherapy for this disease does not exist. present study reports the case a 40-year-old female with tumor that originally arose in right orbit and subsequently relapsed. patient was started on pazopanib monotherapy following treatment two investigational drugs, smoothened inhibitor then phosphatidylinositol...
To determine the long-term outcomes of ocular adnexal lesions in immunoglobulin G4-related ophthalmic disease (IgG4-ROD).This retrospective, non-randomised exploratory study included 82 patients with lesions. We evaluated 71 during median follow-up period 30 months, who underwent either watchful waiting (n=20; range 12-90 months) or systemic corticosteroid treatment, delivered according to consensus guidelines (n=51; 9- 115 months). also analysed factors that might contribute recalcitrance...
Abstract A 9‐year‐old boy who received allogeneic stem cell transplantation began to vomit from day 10 after transplantation. In addition vomiting, the patient had a fever (from 26) and severe headache 34). His cerebrospinal fluid (CSF) (day 41) demonstrated pleocytosis with an absence of leukemic cells. Although patient's symptoms were resolved further supportive care, abrupt onset bilateral decreased vision occurred at 54. He was diagnosed optic neuritis, due presence disc edema redness....
To evaluate the long-term efficacy and toxicity of radiation therapy in patients with Stage IE primary ocular adnexal mucosa-associated lymphoid tissue lymphoma.We designed a retrospective analysis to 81 lymphoma treated between 2006 2016. The median dose was 30 Gy (range, 30-36 15-18 fractions). Local control, progression-free survival, overall cumulative incidence Grade 3 cataract were calculated by using Kaplan-Meier method.The follow-up time 74 months 4-157 months). 5-year local control...
Idiopathic orbital inflammation (IOI) is a group of inflammatory diseases unknown etiopathogenesis. We investigated whether patients with IOI have clinical heterogeneity based on the presence (typical group) or absence (atypical unique onset that periocular symptoms emerge suddenly but progress slowly.This retrospective cohort study included 195 diagnosed IOI. analysed data patients, including outcomes corticosteroid treatment, in two subgroups stratified basis (130 patients) (65...
Abstract Background Female carriers of a balanced X; autosome translocation generally undergo selective inactivation the normal X chromosome. This is because critical genes within autosomal region derivative chromosome would compromise cellular function. We here report female patient with bilateral retinoblastoma and severe intellectual disability who carries reciprocal X-autosomal translocation. Case presentation Cytogenetic molecular analyses, HUMARA (Human androgen receptor) assay,...
To determine the clinicopathological properties of ocular adnexal marginal zone B cell lymphomas (MZBLs) with CD5+ cells.This study determined MZBL samples from 97 patients MZBLs and searched for hallmarks systemic autoimmunity in these patients.Two elderly female were found to have cells; flow cytometry analysis suggested that one had clonal proliferation. The levels anti-single stranded (SS)-DNA anti-SS-A/Ro antibodies two significantly higher than those controls matched age, gender...