A5108669073- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Body Composition Measurement Techniques
- Frailty in Older Adults
- Scoliosis diagnosis and treatment
- Muscle activation and electromyography studies
- Advanced Sensor and Energy Harvesting Materials
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Adipose Tissue and Metabolism
- Cancer Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Bone health and osteoporosis research
- Gastric Cancer Management and Outcomes
- Effects of Vibration on Health
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- Dysphagia Assessment and Management
- Musculoskeletal pain and rehabilitation
- Prosthetics and Rehabilitation Robotics
- Plant Disease Management Techniques
- Ubiquitin and proteasome pathways
- Recycling and utilization of industrial and municipal waste in materials production
Kurume University Hospital
2016-2025
University of Health Sciences
2023
Hyogo University of Health Sciences
2023
Juntendo University
2023
Kurume University
2000-2022
Tokushima College of Technology
2017
Tokyo Institute of Technology
2016
Tottori University
2015
Sarcopenia and physical disability assessed by a 6-min walking test (6MWT) are associated with poor prognosis of patients chronic liver disease (CLD). However, CLD hepatocellular carcinoma (HCC) mostly rest in bed during hospitalization. We aimed to investigate the effects therapeutic exercise on function, 6MWT, skeletal muscle mass HCC treatment CLD.We enrolled 54 (median age, 76 years). During hospitalization, performed combination stretching, strength training, balance practice, endurance...
Abstract Background and Aim Sarcopenia is a prognostic factor in hepatocellular carcinoma (HCC) patients. HCC patients who underwent transcatheter arterial chemoembolization (TACE) are at risk of muscle atrophy. We aimed to investigate the effects in‐hospital exercise on mass factors associated with hypertrophy TACE. Methods enrolled 209 Patients were classified into either an ( n = 102) or control 107) group. In group, treated (median 2.5 metabolic equivalents/20–40 min/day). The evaluated...
Muscle strength and joint nervous system functions decline with age in patients undergoing hemodialysis. The Japanese Orthopaedic Association has defined locomotive syndrome (LoS) as a musculoskeletal disorder primarily caused by aging. Therefore, this study aimed to investigate the prevalence of LoS identify factors associated its development Patients receiving outpatient hemodialysis at Kurume University Hospital were categorized into non-LoS groups using cutoff value 25-question Geriatric...
Sarcopenia is a prognostic factor for patients with hepatocellular carcinoma (HCC). Cancer rehabilitation (CR) improves patients' physical function and muscle mass. We investigated the effects of CR on prognosis HCC. The present study was prospective observational study, which analyzed 152 HCC who underwent transcatheter arterial chemoembolization (TACE) between 2013 2016. Patients were classified into (n=85) control (n=67) groups. mass evaluated by changes in skeletal index (SMI) before...
Biological soil disinfestation (BSD) using plant biomass incorporation is an effective method and a good alternative to chemical fumigants for controlling soil-borne pathogens. In this study the bacterial communities in pot treated with three different BSD conditions (without Brassica juncea L. plants or bran of wheat, Triticum aestivum L.) were analyzed mainly molecular techniques. Earlier dropping redox potential both biomass-treated soils indicated rapid development anaerobic soil. The...
Frailty including physical inactivity is associated with the survival of patients hepatocellular carcinoma (HCC). We aimed to investigate effects in-hospital exercise on frailty in HCC. This was a multi-center observational study. Patients HCC were classified into (n = 114) and non-exercise 67) groups. The group treated mixture aerobic resistance exercises (20–40 min/day, median four days). assessed using liver index (LFI). Factors for changes LFI examined by multivariate decision-tree...
Aim Walking speed and grip strength are parameters of muscle function; however, evaluating walking is not always available in clinical practice. We aimed to investigate the impact on evaluation dysfunction chronic liver disease (CLD) patients with hepatocellular carcinoma (HCC). Methods enrolled 107 consecutive CLD HCC this study (age 76 years [range 60–92 years]; female/male 39/68; body mass index 22.9 20.0–25.3]; hepatitis/liver cirrhosis 25/82). Muscle was evaluated using Asian Working...
Muscle atrophy is a prognostic factor for patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). The Liver Frailty Index (LFI) simple physical function test; however, an association between LFI muscle mass remains unclear. We aimed to investigate the utility of predicting in CLD HCC.We enrolled 138 HCC (aged 77 years, female/male 34.8%/65.2%). was assessed by skeletal index, were classified into group (n = 109) or non-muscle 29). Physical frailty LFI. optimal cut-off...
Abstract Aims Exercise is effective for the prevention of liver cancer. exerts biological effects through regulation microRNAs (miRNAs) and cytokines/myokines. We aimed to investigate low‐intensity resistance exercise on serum miRNA cytokine/myokine expressions in subjects with no habits. Methods enrolled seven male habits this prospective before‐after study. All performed a program (three metabolic equivalents, approximately 20 min/session). Serum were evaluated using microarrays. Kyoto...
We aimed to investigate the impact of muscle atrophy and neutrophil-to-lymphocyte ratio (NLR), a sub-clinical biomarker inflammation nutrition, on prognosis patients with unresectable advanced gastric cancer. retrospectively enrolled 109 stage IV cancer (median age 69 years; female/male 22%/78%; median observational period 261 days). Independent factors profiles for overall survival (OS) were determined by Cox regression analysis decision-tree analysis, respectively. OS was calculated using...
The ubiquitin-proteasome system (UPS) is a selective protein degradation that plays critical role in many essential biological processes by regulating the existence of various cellular proteins. target proteins UPS are recognized and tagged with polyubiquitin chains E3 ubiquitin ligases, which have high substrate-specific activities. Here we present novel injectable imaging probe POL-N can detect UPS-regulated hypoxia-inducible factor (HIF) activity vivo. Because luciferase fused to...
The outcome of patients with hepatocellular carcinoma (HCC) is still poor. Decorin a small leucine-rich proteoglycan, which exerts antiproliferative and antiangiogenic properties in vitro. We aimed to investigate the associations decorin physical function prognosis HCC. enrolled 65 HCC treated transcatheter arterial chemoembolization (median age, 75 years; female/male, 25/40). Serum levels were measured using enzyme-linked immunosorbent assays; classified into High or Low groups by median...
Abstract Background Sarcopenia frequently occurs in patients with liver cirrhosis (LC). The skeletal muscles secrete myokines, including myostatin, irisin, and decorin, which regulate muscle mass. This study aimed to investigate the association between myokine levels mass identify independent factors for LC. Methods Results Thirty‐nine LC were enrolled this (mean age, 75 years [41–84], female/male, 19/20) classified into atrophy or non‐atrophy groups according Japan Society of Hepatology...
Nivolumab extends the overall survival (OS) of patients with advanced gastric cancer (AGC). Intramuscular adipose tissue (IMAT) is associated prognosis various cancers. We investigated effect IMAT on OS in AGC treated nivolumab.We enrolled nivolumab (n = 58, 67 years old, men/women 40/18). The subjects were classified into long-term or short-term groups according to median value. was evaluated using computed tomography scans at umbilical level. decision tree algorithm employed reveal profile...
Severe ascites is an adverse event of ramucirumab (RAM), a second‑line treatment for hepatocellular carcinoma (HCC). Ascites can be associated with various factors, including nutritional status and muscle quality. The aim the present study was to investigate prevalence profiles RAM‑associated severe in patients HCC. This retrospective enrolled 14 consecutive HCC treated RAM (median age, 72 years; Barcelona Clinic Liver Cancer stage B/C, 6/8). Nutritional quality were evaluated using...
Objective: Muscle atrophy is associated with autologous stem cell transplantation (ASCT) -related outcomes in patients malignant lymphoma (ML). However, the impact of ASCT on muscle mass remains unclear ML. The aims this study were to investigate changes and risk profiles for after ASCT. Method: We enrolled 40 refractory ML (age 58 [20-74] years, female/male 16/24, body index (BMI) 21.1 kg/m2 [17.1-29.6]). Psoas was assessed using psoas (PMI) before Statistical analysis used: Independent...
Activities of daily living (ADL) are frequently impaired in patients with hepatocellular carcinoma (HCC). In this retrospective study, we aimed to investigate the effects physical therapy on ADLs HCC during hospitalization for cancer treatment. Nineteen were enrolled. During hospitalization, performed a combination resistance training, stretching, and aerobic exercise (20–60 min/day). assessed using functional independence measure (FIM). Changes FIM evaluated by before–after analysis. No...
Abstract Aims Sarcopenia is a prognostic factor in patients with hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may aggravate sarcopenia because of post‐embolization syndrome. The aims this study are to investigate changes skeletal muscle mass after TACE and its risk profiles HCC. Methods results We enrolled 104 HCC (age 73.5 [41.0–88.0] years, female/male 35/69, body index 22.4 [16.0–32.7]). Changes were evaluated by Δskeletal (SMI) using computed tomography...
Trunk muscle mass can be evaluated by skeletal index (SMI), which is a prognostic factor in patients with hepatocellular carcinoma (HCC); however, this requires the use of computed tomography, and simpler assessment for trunk urgently needed. We aimed to examine whether an association between SMI lower extremity compartments including subcutaneous fat thickness limbs (SFT-LL) could identified means ultrasonography HCC.We retrospectively enrolled male HCC (n=30). was using tomography....
We developed a low-intensity 10-min resistance exercise program for nonalcoholic fatty liver disease (NAFLD). report case of NAFLD with elevated hepatic fibrosis indices, which were improved by 60-week daily program. A 71-year-old female patient whose stage corresponded to F2 was referred our hospital. She performed the once day no changes in other lifestyle habits and medications. The homeostasis model assessment-insulin value NAFLD-liver fat score, Hepamet enhanced score decreased. FIB-4...
Abstract Lumbar spinal stenosis (LSS) can interfere with daily life and quality of (QOL). Evaluating physical function QOL helping patients to improve is the focus rehabilitation. Phase angle (PhA) assessment widely used measure body composition considered an indicator QOL. This study investigated relationship between PhA function, activity, in LSS. PhA, handgrip strength, walking speed, Timed Up Go test (TUG), Life Space Assessment (LSA), Prognostic Nutritional Index (PNI), Japanese...