A5019660253- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Diabetes Treatment and Management
- Diabetes Management and Research
- Bladder and Urothelial Cancer Treatments
- Nerve injury and regeneration
- Prostate Cancer Treatment and Research
- Chronic Kidney Disease and Diabetes
- Urinary and Genital Oncology Studies
- Trace Elements in Health
- Nutrition and Health in Aging
- Antibiotics Pharmacokinetics and Efficacy
- Radiopharmaceutical Chemistry and Applications
- Metabolism, Diabetes, and Cancer
- Lung Cancer Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Diagnosis and Treatment
- Balance, Gait, and Falls Prevention
- COVID-19 impact on air quality
- Sleep and related disorders
- Pancreatic function and diabetes
- Environmental Education and Sustainability
- Multiple and Secondary Primary Cancers
- Anesthesia and Sedative Agents
Hiroshima Prefectural Rehabilitation Center
2024
Jikei University School of Medicine
2021-2024
Matsuyama Shimin Hospital
2007-2024
University of Occupational and Environmental Health Japan
2015-2023
National Sagamihara Hospital
2014-2022
Hiroshima University
2017-2021
ORCID
2021
Kurume University
2018-2020
Saiseikai Nakatsu Hospital
2020
Tokyo National Hospital
2015
Excessive activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) plays a prominent role in various models cellular injury. Here, we identify (PAR) polymer, product PARP-1 activity, as previously uncharacterized cell death signal. PAR polymer is directly toxic to neurons, and degradation by glycohydrolase (PARG) or phosphodiesterase 1 prevents polymer-induced death. PARP-1-dependent, NMDA excitotoxicity cortical neurons reduced neutralizing antibodies overexpression PARG....
The water channel AQP4 is concentrated in perivascular and subpial membrane domains of brain astrocytes. These membranes form the interface between neuropil extracerebral liquid spaces. anchored at these by its carboxyl terminus to α-syntrophin, an adapter protein associated with dystrophin. To test functions pool, we studied mice homozygous for targeted disruption gene encoding α-syntrophin (α- Syn −/− ). animals show a marked loss from but no decrease other domains, as judged quantitative...
Cytochrome P450 epoxygenase metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are produced in the brain and perform important biological functions, including vasodilation neuroprotection. However, rapidly metabolized via soluble epoxide hydrolase (sEH) dihydroxyeicosatrienoic (DHETs). We tested hypothesis that sEH gene deletion is protective against focal cerebral ischemia through enhanced collateral blood flow.sEH knockout (sEHKO) mice with without antagonist 14, 15...
The aquaporin-4 (AQP4) pool in the perivascular astrocyte membranes has been shown to be critically involved formation and dissolution of brain edema. Cerebral edema is a major cause morbidity mortality stroke. It therefore essential know whether AQP4 up- or down-regulated after an ischemic insult, because such changes would determine time course formation. Here we demonstrate by quantitative immunogold cytochemistry that striatum neocortex show distinct patterns expression reperfusion phase...
<b><i>Background:</i></b> Japanese cedar (JC) pollinosis is the most common seasonal allergic rhinitis in Japan. Standardized JC pollen extract available for subcutaneous immunotherapy, but this treatment limited by potentially serious side effects. The aim of double-blind, randomized comparative study was to evaluate efficacy and safety standardized a new oral formulation (CEDARTOLEN®, Torii Pharmaceutical Co., Ltd., Tokyo, Japan) sublingual immunotherapy (SLIT)...
Abstract Increases in COX‐2 enzymatic activity and prostaglandin production have been associated with neuronal injury both acute age‐related degenerative neurological diseases. In this study, we tested the effects of increased a model transient focal ischemia using transgenic mouse which human is constitutively expressed selectively neurons striatum, cerebral cortex, hippocampus. These mice harbor elevated levels PGE 2 that are 10‐fold higher than nontransgenic levels. A significant increase...
This study was undertaken to identify characteristics of follicular regulatory T (Tfr) cells and elucidate the mechanisms by which helper (Tfh) convert Tfr cells. We probed phenotype in patients with systemic lupus erythematosus (SLE) underlying transcriptional regulation using cytokine-induced STAT family factors.Peripheral blood mononuclear from 41 SLE 26 healthy donors were used sort out memory Tfh cell subset, cultured under various conditions. The flow cytometry quantitative polymerase...
Abstract Background and Aim Sarcopenia is a prognostic factor in hepatocellular carcinoma (HCC) patients. HCC patients who underwent transcatheter arterial chemoembolization (TACE) are at risk of muscle atrophy. We aimed to investigate the effects in‐hospital exercise on mass factors associated with hypertrophy TACE. Methods enrolled 209 Patients were classified into either an ( n = 102) or control 107) group. In group, treated (median 2.5 metabolic equivalents/20–40 min/day). The evaluated...
Social interaction can have a profound effect on health. The purpose of the present study was to determine whether affiliative social interactions before and after stroke improve ischemic outcomes as assessed through histological analysis behavioral assays.Male female C57BL/6 mice were housed individually or with an ovariectomized female. Behavioral assessments made 24 hours 60 90 minutes transient intraluminal middle cerebral artery occlusion (MCAO) SHAM surgery 7 days reperfusion. Two...
We determined the population pharmacokinetics of vancomycin (VAN) using glomerular filtration rate (GFR) estimated from serum cystatin C concentration. examined predictive performance trough VAN concentration for determination initial dose by a new model analysis pharmacokinetic parameters. Data 86 patients were used to estimate values Analysis with nonlinear mixed-effects modeling program was done one-compartment model. 78 evaluate The GFR Hoek's formula correlated linearly clearance (VAN...
Basic studies have shown that glucagon-like peptide-1 (GLP-1) analogs exert a direct protective effect on the vascular endothelium in addition to their indirect effects postprandial glucose and lipid metabolism. GLP-1 are also reported inhibit endothelial dysfunction. This study examined whether analog exenatide inhibits dysfunction patients with type 2 diabetes mellitus (T2DM).Seventeen T2DM underwent meal tolerance test examine changes function metabolism, both without (baseline) after...
Sarcopenia is a prognostic factor for patients with hepatocellular carcinoma (HCC). Cancer rehabilitation (CR) improves patients' physical function and muscle mass. We investigated the effects of CR on prognosis HCC. The present study was prospective observational study, which analyzed 152 HCC who underwent transcatheter arterial chemoembolization (TACE) between 2013 2016. Patients were classified into (n=85) control (n=67) groups. mass evaluated by changes in skeletal index (SMI) before...
Poly(ADP-ribose) polymerase-2 (PARP-2) is a member of the PARP enzyme family, and, similarly to PARP-1, catalyzes formation ADP-ribose polymers in response DNA damage. While PARP-1 overactivation contributes ischemic cell death, no information available regarding role PARP-2. In this study, we evaluated impact PARP-2 deletion on histopathological outcome from two different experimental models cerebral ischemia. Male −/- mice and wild-type (WT) littermates were subjected either 2 h middle...
Deoxypyrimidine kinase (deoxythymidine [TdR] and deoxycytidine kinase) activity was induced in human embryonic lung cells after infection with varicella-zoster virus (VZ virus). Increased enzyme also produced by using cell-associated as inoculum instead of cell-free virus. Anti-VZ serum inhibited both the appearance cytopathic effect induction activity. The TdR more thermostable than that herpes simplex type 1. Also, VZ virus-infected dTTP less mock-infected 1-infected cells.
Fundamental cures of central nervous system (CNS) diseases are rarely achieved due to the low regenerative ability CNS. Recently, cell-based therapy using mesenchymal stem cells (MSCs) has been explored as an effective treatment for CNS diseases. Among various tissue-derived MSCs, we have isolated human cranial bone-derived MSCs (cMSCs) in our laboratory. In addition, focused on simulated microgravity (MG) a valuable culture environment MSCs. However, detailed mechanisms underlying...
We analyzed the cell characteristics, neuroprotective, and transplantation effects of human cranial bone-derived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats compared with iliac (hiMSCs). The expressions brain-derived neurotrophic factor (BDNF) vascular endothelial growth (VEGF ) as factors were both MSCs. hiMSCs or hcMSCs intravenously administered into at 3 24 h after middle cerebral artery occlusion (MCAO) neurological function was evaluated. survival rate neuroblastoma ×...
The functional disorders caused by central nervous system (CNS) diseases, such as ischemic stroke, are clinically incurable and current treatments have limited effects. Previous studies suggested that cell-based therapy using mesenchymal stem cells (MSCs) exerts therapeutic effects for stroke. In addition, the characteristics of MSCs may depend on their sources. Among derived tissues MSCs, we focused cranial bones originating from neural crest. We previously demonstrated neurogenic potential...
Abstract Cell-based therapy using mesenchymal stem cells (MSCs) is a novel treatment strategy for spinal cord injury (SCI). MSCs can be isolated from various tissues, and their characteristics vary based on the source. However, reports demonstrating effect of transplanted rat cranial bone-derived (rcMSCs) SCI models are lacking. In this study, we determined transplanting rcMSCs in models. were established collected bone marrow bones. rats weight-drop method intravenously with at 24 h post...
In recent years, it has been suggested that the glomerular filtration rate (GFR) can be predicted on basis of serum cystatin C concentrations and this measurement is more sensitive than creatinine concentration as a marker renal function. study, to investigate clinical utility initial dose setting vancomycin by population mean method with use function, we compared correlations between measured based or in elderly (>/=65 years old) nonelderly (<65 patients. An analysis prediction accuracy...
This study examined the impact of platelet transfusion (PLT) on survival intracerebral hemorrhage (ICH) patients who had been administered anti-platelet agents (APA). retrospective cohort analysis investigated 432 (259 men, 60%) were newly diagnosed with ICH between January 2006 and June 2011 at tertiary emergency center Kitasato University Hospital. Median age arrival was 67.0 years (range, 40–95 years). subcortical in 72 (16.7%), supratentorial 233 (53.9%), infratentorial 133 (30.8%). PLT...
Background There is sparse evidence regarding optimal management and prognosticators for oncologic outcomes in patients with clinical node‐positive (cN+) upper tract urothelial carcinoma (UTUC). Methods We retrospectively analyzed the data from 105 UTUC cN1‐2M0 between June 2010 2022 at multiple institutions affiliated our university. At time of diagnosis, all received standard‐of‐care treatment including radical nephroureterectomy (RNU), chemotherapy, and/or palliative care. employed a Cox...
Zinc levels in the prostate have been reported to be associated with development and progression of malignant cells. To investigate reason why zinc content decreases during cancer an androgen-independent state, we compared expression metallothionein transporters between androgen-responsive LNCaP cells its subline, AIDL showed lower than comparable androgen receptor cells, consistent some clinical aspects prostatic cancer. exhibited a transporter 1 (ZnT1) higher ZnT3 The metallothionein,...
Although prostate cancer is a very common form of malignancy in men, the clinical significance androgen deprivation therapy (ADT) with abiraterone acetate versus nonsteroidal antiandrogen bicalutamide has not yet been verified patients high-risk metastatic hormone-sensitive (mHSPC). The present study was designed to initiate this verification real-world Japanese practice.We retrospectively analyzed records 312 mHSPC based on LATITUDE criteria and had received ADT (n = 212) or 100) between...