A5018304441- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Human-Animal Interaction Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Evolutionary Psychology and Human Behavior
- Intensive Care Unit Cognitive Disorders
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Neurotransmitter Receptor Influence on Behavior
- Cancer-related cognitive impairment studies
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Neurotoxicity Research
- Identity, Memory, and Therapy
- Health and Lifestyle Studies
- S100 Proteins and Annexins
- Immune responses and vaccinations
- Menopause: Health Impacts and Treatments
- Mitochondrial Function and Pathology
The Ohio State University
2004-2025
Institute for Behavioral Medicine
2006-2025
University of Maryland, College Park
2014-2024
The Ohio State University Wexner Medical Center
2022-2024
Princeton University
2007-2015
3M (United States)
2009
Emory University
2006
Oregon Health & Science University
2005
Johns Hopkins Hospital
2005
UConn Health
2005
Aversive stressful experiences are typically associated with increased anxiety and a predisposition to develop mood disorders. Negative stress also suppresses adult neurogenesis restricts dendritic architecture in the hippocampus, brain region regulation. The effects of aversive on hippocampal structure function have been linked stress-induced elevations glucocorticoids. Normalizing corticosterone levels prevents some deleterious consequences stress, including suppressed structural...
From 5 to 22 months of age, cognitive and emotional responses nulliparous, primiparous, multiparous rats were assessed using a dry land maze (DLM) an elevated plus-maze (EPM) at 4-month intervals. Parous exhibited improved spatial memory in the probe competitive versions DLM, more exploration EPM novel stimulus test relative nulliparous females. The females, however, outperformed parous during DLM visual cue 17 age. At 23 months, no differences stressed corticosterone levels or Golgi-stained...
Adult neurogenesis is often studied by labeling new cells with the thymidine analog bromodeoxyuridine (BrdU) and using immunohistochemical methods for their visualization. Using this approach, considerable variability has been reported in number of produced dentate gyrus adult rodents. We examined whether methods, including BrdU antibodies from different vendors (Vector, BD, Roche, Dako, Novocastra, Accurate) DNA denaturation pretreatments alter quantitative qualitative patterns labeling....
Abstract Physical exercise enhances adult neurogenesis in the hippocampus. Running induces uptake of blood insulin‐like growth factor‐I (IGF‐I) into brain. A causal link between these two phenomena has been reported; running‐induced increases can be blocked by peripheral infusion anti‐IGF‐I. also alters other aspects hippocampal structure, including dendritic spine density. It remains unclear, however, whether effects are mediated through an IGF‐I mechanism. To examine this possibility, we...
Paternal care is rare among mammals, occurring in ≈6% of species. California mice (Peromyscus californicus) are unusual; fathers participate extensively raising their young and display the same components parental as mothers, with exception nursing. Parenting a complex experience, having stressful enriching aspects. The hippocampus sensitive to experience responds both stress environmental enrichment changes structure function. In rats, where females exclusively for offspring, parenting...
Social interaction can have a profound effect on health. The purpose of the present study was to determine whether affiliative social interactions before and after stroke improve ischemic outcomes as assessed through histological analysis behavioral assays.Male female C57BL/6 mice were housed individually or with an ovariectomized female. Behavioral assessments made 24 hours 60 90 minutes transient intraluminal middle cerebral artery occlusion (MCAO) SHAM surgery 7 days reperfusion. Two...
In vitro studies have pointed to the collapsin response mediator proteins (CRMPs) as key regulators of neurite outgrowth and axonal differentiation. CRMP3 is expressed mostly in nervous system during development but remains at high levels hippocampus adults. To explore function vivo, we generated mice with targeted disruption gene. Immunohistochemistry Golgi staining CA1 showed abnormal dendrite spine morphogenesis CRMP3-deficient mice. Apical dendrites displayed an increase undulation a...
Stress is an important risk factor for cardiovascular disease; however, most of the research on this topic has focused incidence rather than outcome. The goal study was to determine effects prior exposure chronic stress ischemia-induced neuronal death, microglial activation, and anxiety-like behavior.In Experiment 1, mice were exposed 3 weeks daily restraint (3 hours) then subjected either 8 minutes cardiac arrest/cardiopulmonary resuscitation (CA/CPR) or sham surgery. Anxiety-like behavior,...
Abstract Following diagnosis but before treatment, up to 30% of breast cancer patients report behavioral side effects (e.g., anxiety, depression, memory impairment). Our rodent mammary tumor model recapitulates aspects these sequelae, as well elevated circulating and brain inflammatory mediators. Neuroinflammation is a proposed mechanism underlying the etiology mood disorders cognitive deficits, therefore may be contributing tumor‐associated effects. The cellular mechanisms by which...
Abstract Aging is associated with compromised hippocampal function and reduced adult neurogenesis in the dentate gyrus. As new neurons have been linked to functions, such as cognition, age‐related decline neuron formation may contribute impaired function. We investigated whether a rewarding experience known stimulate young rats, namely sexual experience, would restore production middle‐aged rats. Sexual enhanced number of newly generated gyrus both single repeated exposures Following...
Abstract Background Dopaminergic circuits play important roles in the motivational control of behavior and dysfunction dopaminergic have been implicated several psychiatric disorders, such as schizophrenia depression. While these disorders exhibit different incidence rates men women, potential sex differences underlying neural are not well-understood. Previous anatomical tracing studies mammalian species revealed a prominent circuit projection connecting midbrain ventral tegmental area (VTA)...
The hippocampus is highly sensitive to ischemia and one of the most extensively damaged regions brain during cardiac arrest. Damage can subsequently lead learning memory deficits. current study used Morris water maze characterize spatial deficits elicited by 8 min arrest with cardiopulmonary resuscitation (CA/CPR) in mice, which associated a 25-50% decrease CA1 neurons. Mice were trained navigate prior CA/CPR or sham surgery (SHAM). They retested on days 7 postsurgery; both SHAM groups able...
Adolescents living with human immunodeficiency virus (HIV) comprise approximately 12% of the HIV-positive population worldwide. adolescents experience a higher rate clinical depression, greater risk sexual and drug abuse behaviors, decreased adherence to highly active antiretroviral therapies (HAART). Using adolescent HIV-1 transgenic rats (HIV-1 tg) that display related immune response alterations pathologies, this study tested hypothesis developmental expression HIV-1-related proteins...
Abstract Introduction Parenting alters the hippocampus, an area of brain that undergoes significant experience‐induced plasticity and contributes to emotional regulation. While relationship between maternal care hippocampal neuroplasticity has been characterized, extent which fatherhood structure function hippocampus is far less understood. Methods Here, we investigated what altered anxiety regulation dendritic morphology using highly paternal California mouse ( Peromyscus californicus )....