A5088471566- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Pain Mechanisms and Treatments
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Salivary Gland Disorders and Functions
- Temporomandibular Joint Disorders
- Multiple Myeloma Research and Treatments
- Urinary and Genital Oncology Studies
Niigata University
2023-2025
Jikei University School of Medicine
2019-2025
Abstract Background Despite its demonstrated efficacy in prolonging overall survival (OS) and delaying skeletal-related events the ALSYMPCA trial, optimal timing of radium-223 initiation remains unclear. This study investigated factors influencing treatment outcomes, including completion rates survival. Methods retrospective, multi-institutional included 164 patients with metastatic castration-resistant prostate cancer (CRPC) who received therapy. The primary endpoint was OS following...
This study examined the effects of treadmill running (TR) regimens on craniofacial pain- and anxiety-like behaviors, as well their neural changes in specific brain regions male mice subjected to repeated social defeat stress (SDS) for 10 days. Behavioral immunohistochemical experiments were conducted evaluate impact TR SDS-related those epigenetic activity markers anterior cingulate cortex (ACC), insular (IC), rostral ventromedial medulla (RVM), cervical spinal dorsal horn (C2). responses...
Although prostate cancer is a very common form of malignancy in men, the clinical significance androgen deprivation therapy (ADT) with abiraterone acetate versus nonsteroidal antiandrogen bicalutamide has not yet been verified patients high-risk metastatic hormone-sensitive (mHSPC). The present study was designed to initiate this verification real-world Japanese practice.We retrospectively analyzed records 312 mHSPC based on LATITUDE criteria and had received ADT (n = 212) or 100) between...
Abstract Purpose The aim of this study was to investigate the oncologic efficacy combining docetaxel with androgen deprivation therapy (ADT) versus nonsteroidal antiandrogen (NSAA) ADT in patients high-volume metastatic hormone-sensitive prostate cancer (mHSPC) focus on effect sequential a real-world clinical practice setting. Methods records 382 who harbored mHSPC, based CHAARTED criteria, and had received either ( n = 92) or NSAA (bicalutamide) 290) were retrospectively analyzed. cohorts...
Abstract The conditions of stress contagion are induced in bystanders without direct experiences stressful events. This study determined the effects on masseter muscle nociception mice. Stress was developed after cohabitating with a conspecific mouse subjected to social defeat for 10 days. On Day 11, increased anxiety‐ and orofacial inflammatory pain‐like behaviors. c‐Fos FosB immunoreactivities evoked by stimulation were upper cervical spinal cord, while expressions rostral ventromedial...
Objective To evaluate the clinical usefulness of Immunotherapy Response Evaluation Criteria in Solid Tumours (iRECIST) patients with metastatic urothelial carcinoma (UC) treated pembrolizumab. The iRECIST is designed to accurately capture tumour response immunotherapy. Patients and methods We conducted a multicentre retrospective study evaluating utility 91 UC second‐line objective (OR) time progression (TTP) accordance both RECIST version 1.1 were compared overall survival (OS) risk...
Abstract Objective We determined the optimal timing for initiating androgen receptor signaling inhibitor (ARSI) therapy in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC) and assessed its impact on oncological outcomes. Materials methods This retrospective study included 145 nmCRPC who received enzalutamide, apalutamide or darolutamide at Jikei University Hospital affiliated institutions between May 2014 November 2022. Patients were stratified based...
Abstract Background Docetaxel (DOC) has been widely accepted as a therapeutic option for castration‐resistant prostate cancer (CRPC). Evidence‐based clinical guidelines have stipulated its use up to 10 cycles in most health care systems. There paucity of information regarding potential benefits over cycles. The purpose this study is re‐examine the rationale concerning DOC CRPC. Methods Between July 2007 and 2016, total 122 CRPC patients received at least five Jikei University affiliate...