A5007054640- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Urinary and Genital Oncology Studies
- Esophageal Cancer Research and Treatment
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Statistical Methods in Clinical Trials
- Adrenal and Paraganglionic Tumors
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Cervical Cancer and HPV Research
- Single-cell and spatial transcriptomics
- Ion Transport and Channel Regulation
- Neurofibromatosis and Schwannoma Cases
- Ferroptosis and cancer prognosis
Jikei University School of Medicine
2014-2025
Kansai Rosai Hospital
2023
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Abstract Background Despite its demonstrated efficacy in prolonging overall survival (OS) and delaying skeletal-related events the ALSYMPCA trial, optimal timing of radium-223 initiation remains unclear. This study investigated factors influencing treatment outcomes, including completion rates survival. Methods retrospective, multi-institutional included 164 patients with metastatic castration-resistant prostate cancer (CRPC) who received therapy. The primary endpoint was OS following...
MicroRNA-based screening identifies the novel regulators of EV secretion from cancer cells.
Bone metastases are still incurable and result in the development of clinical complications decreased survival for prostate cancer patients. Recently, a number studies have shown that extracellular vesicles (EVs) play important roles tumour progression. Here, we show EVs from metastatic cells promote osteoclast formation presence receptor activator NF-κB ligand (RANKL). EV characterization followed by functional siRNA screening identified CUB-domain containing protein 1 (CDCP1),...
Background/Aim: The lung immune prognostic index (LIPI), which is determined by assessing the derived neutrophil-to-lymphocyte ratio in conjunction with level of lactate dehydrogenase, predicts outcomes various cancers. Its utility as a preoperative biomarker upper tract urothelial carcinoma (UTUC) patients remains unexplored. Patients and Methods: This retrospective study UTUC who underwent radical nephroureterectomy. were stratified into favorable, intermediate, poor LIPI groups....
The incidence of prostate cancer (PCa) has increased worldwide in recent years along with the recommendation for prostate-specific antigen testing, and mortality been declining owing to advances fragmented simplified access treatment care. However, GLOBOCAN (Global Cancer Observatory) data show that this result is not true all countries. It reported degree PCa progression at diagnosis survival rates differ among racial groups. Based on various comparisons between Caucasians Asians, it was...
Background: Few studies have addressed the efficacy of nephroureterectomy for managing upper tract urothelial carcinoma (UTUC) in very elderly patients (those aged 85 years and older). We aimed to elucidate association between age clinical outcomes with UTUC who underwent radical nephroureterectomy. Methods: retrospectively analyzed data from 847 UTUC. These were classified into four brackets: young (≤64 years, n=177), intermediate (65–74 n=300), (75–84 n=312), (≥85 n=58). applied logistic...
Targeting extracellular vesicle (EV) secretion can have potential clinical implications for cancer therapy, however the precise regulatory mechanisms of EV are not fully understood. Recently, we shown a novel pathway biogenesis in PCa cell lines, PC3 and PC3M. However, as characteristics EVs divergent even among hypothesized that other pathways or common still exist. Here, performed quantitative high-throughput screening to determine key genes involved 22Rv1 cells, which secrete different...
Radical cystectomy is the gold-standard treatment for muscle-invasive bladder cancer and aggressive non-muscle-invasive cancer. To enhance clinical decision-making regarding patients with who underwent radical cystectomy, a recurrence prediction biomarker high accuracy urgently needed. In this study, we developed model of after by combining serum microRNA pathological factor.We retrospectively analyzed records 81 between 2008 2016. The dataset was divided into two, Fisher linear discriminant...
Cisplatin (cis-diamminedichloroplatinum II [CDDP] ) is a well-known chemotherapeutic drug that has been used for the treatment of various types human cancers, including head and neck cancer. exerts anticancer effects by causing DNA damage, replication defects, transcriptional inhibition, cell cycle arrest, induction apoptosis. However, resistance one most serious problems with cancer chemotherapy, it causes expected therapeutic to not always be achieved. Here, we analyzed global microRNA...
Cancer cells secrete extracellular vesicles (EVs) to regulate in the tumor microenvironment benefit their own growth and survive patient's body. Although emerging evidence has demonstrated molecular mechanisms of EV release, regulating cancer-specific secretion remains challenging. In this study, we applied a microRNA library reveal universal from cancer cells. Here, identified miR-891b its direct target gene, phosphoserine aminotransferase 1 (PSAT1), which promotes through serine-ceramide...
To evaluate the role of androgen receptor-axis-targeted drugs (ARAT) in non-metastatic castration-resistant prostate cancer (nmCRPC) versus mCRPC.Chemotherapy-naive patients (n = 114) with CRPC who had no metastasis at time diagnosis were included this retrospective study. All treated ARAT Jikei University and its affiliated hospitals from July 2014 to March 2017. The stratified into nmCRPC 81) mCRPC 33) groups according their metastatic status induction. primary outcome measure was...
Guidelines define docetaxel as a first-line therapeutic option for metastatic castration-resistant prostate cancer (mCRPC). However, the role of in non-metastatic (nmCRPC) has not been fully investigated. The aim this retrospective study was to evaluate potential nmCRPC. Clinical outcomes including overall survival were compared between CRPC patients who had introduced while nonmetastatic versus diseases.A total 98 therapy. Of these 46 received nmCRPC, and 52 distant metastases. from time...
Microfluidics is applied in biotechnology research via the creation of microfluidic channels and reaction vessels. Filters are considered to be able simulate microfluidics. A typical example cell culture insert, which comprises two vessels connected by a filter. Cell inserts have been used for years study cell-to-cell communication. These systems generally bucket-in-bucket structure hereafter referred as vertical-type co-culture plate (VTCP). However, VTCPs several disadvantages, such...
Clinically, the osteolytic phenotype is rare in prostate cancer (PCa), and prognosis generally worse than that of osteoblastic phenotype. Osteoblastic (BPCa) a major type bone metastasis. Several factors responsible for osteogenesis have been identified, but molecular mechanism metastasis PCa not fully understood. Here, we show osteogenic tumor‐suppressive roles SERPINA3 LCN2 BPCa. In co‐culture osteoblasts (OBs) BPCa cells, were remarkably upregulated via OB‐derived extracellular vesicles,...
Abstract Antiandrogens were originally developed as therapeutic agents for prostate cancer but are also expected to be effective breast cancer. However, the role of androgen signaling in has long been controversial due limited number experimental models. Our study aimed comprehensively investigate efficacy antiandrogens on In present study, a total 18 cell lines treated with agonist or antagonists receptor (AR). Among tested, only T‐47D cells proliferated an androgen‐dependent manner, while...