A5039425264- Reproductive tract infections research
- Bacterial Infections and Vaccines
- Urinary Tract Infections Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Urology and Nephrology Studies
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Syphilis Diagnosis and Treatment
- Renal cell carcinoma treatment
- Neuroscience and Neuropharmacology Research
- Pneumonia and Respiratory Infections
- Urinary Bladder and Prostate Research
- Renal Transplantation Outcomes and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Urinary and Genital Oncology Studies
- Adrenal and Paraganglionic Tumors
- Urological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Organ Donation and Transplantation
- Clinical practice guidelines implementation
- HIV/AIDS drug development and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Urologic and reproductive health conditions
- Streptococcal Infections and Treatments
Fukuoka University
2011-2021
Jikei University School of Medicine
2018-2021
Fukuoka Tokushukai Hospital
2021
ShinKokura Hospital
2014-2020
Fukuoka University Hospital
2005-2019
Kyushu University
1997-2015
Kurume University Medical Center
2005-2012
Kurume University
1993-2008
Japan Society of Chemotherapy
2008
Rockefeller University
2005
Cyclooxygenase (COX) is a key enzyme in the synthesis of prostanoids. Two isoforms this have been identified: COX-1 and COX-2. Recent studies suggested that COX-2, but not COX-1, may play role colorectal tumorigenesis. In present study, we investigated expression COX-2 as well human hepatocellular carcinoma (HCC) tissues using immunohistochemistry immunoblotting. Forty-four surgically resected HCC with adjacent nontumorous livers (NTs), involving 17 cases chronic viral hepatitis 27...
Recently, pleiotropic benefits of incretin therapy beyond glycemic control have been reported. Although cancer is one the main causes death in diabetic patients, few reports describe anticancer effects incretin. Here, we examined effect drug exendin (Ex)-4, a GLP-1 receptor (GLP-1R) agonist, on prostate cancer. In human tissue obtained from patients after they had undergone radical prostatectomy, GLP-1R expression colocalized with P504S, marker vitro experiments, Ex-4 significantly decreased...
ABSTRACT To assess the antimicrobial resistance of Neisseria gonorrhoeae isolated from 1993 through 1998 in Japan, susceptibility testing was conducted on 502 isolates. Selected isolates were characterized by auxotype and analysis for mutations within quinolone resistance-determining region (QRDR) gyrA parC genes, which confer fluoroquinolone organism. Plasmid-mediated penicillin (penicillinase-producing N. ) decreased significantly 1993–1994 (7.9%) to 1997–1998 (2.0%). Chromosomally...
Dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) plays a central role in medium spiny neurons the neostriatum integration various neurotransmitter signaling pathways. In its Thr-34-phosphorylated form, it acts as potent protein phosphatase-1 inhibitor, and, Thr-75-phosphorylated cAMP-dependent kinase inhibitor. Here, we investigated glutamate-dependent cascades mouse neostriatal slices by analyzing phosphorylation DARPP-32 at Thr-34 Thr-75. Treatment with glutamate (5 mM)...
The prognosis of platinum-based chemotherapy-resistant metastatic urothelial cancer the bladder remains poor. Personalized selection right peptides for each patient could be a novel approach vaccine to boost anticancer immunity.In this randomized, open-label, phase II study, patients ages ≥18 years with progressive after first-line chemotherapy were randomly assigned (1:1) receive personalized peptide vaccination (PPV) plus best supportive care (BSC) or BSC. PPV treatment used maximum four...
Abstract In dopaminergic neurons, chondroitin sulfate (CS) proteoglycans play important roles in neuronal development and regeneration. However, due to the complexity heterogeneity of CS, precise structure CS with biological activity molecular mechanisms underlying its influence on neurons are poorly understood. this study, we investigated ability synthetic oligosaccharides natural polysaccharides promote neurite outgrowth mesencephalic signaling pathways activated by CS. CS‐E...
We fabricated novel tissue engineered urethral grafts using autologously harvested oral cells. report their viability in a canine model.Oral tissues were by punch biopsy and divided into mucosal muscle sections. Epithelial cells from sections cultured as epithelial cell sheets. Simultaneously derived seeded on collagen mesh matrices to form At 2 weeks the sheets joined tubularized 2-layer urethras, which grafted surgically induced defects 10 dogs experimental group. Tissue not applied defect...
The current guidelines recommend a combination of ceftriaxone and azithromycin as first-line treatment gonorrhea in the United States Europe. Despite not being recommended regimen Japan, an oral 2-g dose did become available for gonococcal infections 2009. Recently, emergence azithromycin-resistant Neisseria gonorrhoeae isolates has been reported several countries, including Japan.Antimicrobial susceptibility testing was performed on total 677 clinical N. obtained from January 2010 to...
At partial nephrectomy there is a risk of excessive blood loss, which necessitates transfusion and also results in renal function deterioration when vascular clamp used. We evaluated the usefulness microwave tissue coagulator for cell carcinoma.Partial was performed without pedicle clamping using 4 patients with small kidney tumor.In 3 successful clamping. Mean operative time loss were 203 minutes 153 ml., respectively, no significant complications. In remaining case resection any However,...
BACKGROUND AND OBJECTIVES: Gonococcal fluoroquinolone resistance is now a significant problem in Japan. We generated gonococcal mutants resistant to norfloxacin vitro from sensitive isolates and analysed the contribution of three known mechanisms quinolone Neisseria gonorrhoeae. MATERIALS METHODS: Three clinical N gonorrhoeae susceptible were exposed increasing concentrations norfloxacin. To identify mutations gyrA parC genes mutants, determining regions polymerase chain reaction (PCR)...
No AccessJournal of Urology1 Apr 1994Suppression Renal Scarring by Prednisolone Combined with Ciprofloxacin in Ascending Pyelonephritis Rats Masashi Haraoka, Tetsuro Matsumoto, Koichi Takahashi, Shuta Kubo, Masatoshi Tanaka, and Joichi Kumazawa HaraokaMasashi Haraoka , MatsumotoTetsuro Matsumoto TakahashiKoichi Takahashi KuboShuta Kubo TanakaMasatoshi Tanaka KumazawaJoichi View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35187-XAboutPDF ToolsAdd to favoritesDownload...
Eltrombopag is an oral thrombopoietin receptor agonist that stimulates thrombopoiesis and shows higher exposure in East Asian patients than non-Asian patients. We evaluated the pharmacokinetics, efficacy, safety of eltrombopag Japanese with thrombocytopenia associated chronic liver disease (CLD).
Adrenal rest is uncommon in adults, and usually represents a small lesion incidentally detected during surgery or autopsy. The adrenal can be anywhere along the path of embryonic migration cortex, including celiac axis, genitals broad ligament, may formed with separation cortical fragments by medullary elements from sympathochromaffin tissue into preformed primordium. In addition, even primary adrenocortical carcinoma rare tumor incidence 0.5-2 per million annually; therefore, arising rests...
Abstract Aims/Introduction Incretin therapy is a common treatment for type 2 diabetes mellitus. We have previously reported an anti‐prostate cancer effect of glucagon‐like peptide‐1 receptor (GLP‐1R) agonist exendin‐4. The attenuation cell proliferation in the prostate line was dependent on GLP‐1R expression. Here, we examined relationship between human severity and expression, as well forced expression using lentiviral vector. Materials Methods Prostate tissues were extracted by...