A5044622097- Muscle Physiology and Disorders
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Phytase and its Applications
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Heat shock proteins research
- DNA Repair Mechanisms
- Cell Adhesion Molecules Research
- Blood groups and transfusion
- Advanced Synthetic Organic Chemistry
- Microtubule and mitosis dynamics
- Cell death mechanisms and regulation
- Diabetes and associated disorders
Kyoto Prefectural University of Medicine
2014-2025
Hiroshima University
2001-2024
National Center for Global Health and Medicine
2021
Toujinkai Hospital
2020
Fukuoka University
2007-2015
Shimane University
2010-2011
Osaka University
1987-2004
Kyoto Sangyo University
2001
Ehime University
1991-1992
University of California, San Diego
1988
Abstract Adult T‐cell leukemia‐lymphoma (ATL) is an aggressive peripheral neoplasm that develops after long‐term infection with human leukemia virus (HTLV‐1). SIRT1, a nicotinamide adenine dinucleotide + ‐dependent histone/protein deacetylase, plays crucial role in various physiological processes, such as aging, metabolism, neurogenesis and apoptosis, owing to its ability deacetylate numerous substrates, histone NF‐κB, which implicated exacerbation factor ATL. Here, we assessed how SIRT1...
Various ryanodine receptor 2 (RyR2) point mutations cause catecholamine-induced polymorphic ventricular tachycardia (CPVT), a life-threatening arrhythmia evoked by diastolic intracellular Ca2+ release dysfunction. These occur in essential regions of RyR2 that regulate release. The molecular dysfunction caused CPVT-associated as well the functional consequences remain unresolved. Here, we study most severe mutation (K4750Q) known to date. We define and cellular generated this detail how it...
Abstract Arc , activity‐regulated cytoskeleton‐associated gene, is an immediate early and its expression regulated by a variety of stimuli, such as electric stimulation methamphetamine. The function Arc, however, unknown. To explore this function, we carried out experiments transfecting green fluorescent protein (GFP)‐Arc constructs or using transduction system in hippocampal cultured neurons. We found that the overexpression well induction seizure vivo decreased microtubule‐associated 2...
Growth and differentiation of colonic epithelium are regulated in the three-dimensional (3D) physiological architecture, crypt, deregulation 3D interactions is involved tumorigenesis. Cell-based culture systems provide a suitable approach bridging gap between two-dimensional (2D) animal models. KRAS mutations found at high frequencies human colorectal cancer (CRC); however, KRAS-targeted therapy has not been developed. Here, we have established cell model resembling crypt by use HKe3 cells,...
Abstract Background We previously established a three-dimensional (3-D) colonic crypt model using HKe3 cells which are human colorectal cancer (CRC) HCT116 with disruption in oncogenic KRAS, and revealed the crucial roles of KRAS both inhibition apoptosis cell polarity; however, molecular mechanism KRAS-induced these 3-D specific biological changes remains to be elucidated. Results Among genes that were upregulated by this model, we focused on phosphodiesterase 4B ( PDE4B ) expression levels...
Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved neurotransmission may influence susceptibility to PD.We investigated the relationship of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), dopamine receptor (DR) D2 and DRD4 PD risk with special attention interaction cigarette smoking among 238 patients 369 controls a Japanese population.Subjects AA genotype MAOB rs1799836 showed significantly increased...
ZFAT (also known as ZNF406), originally identified a candidate gene for autoimmune thyroid disease, encodes zinc-finger protein, however, its function has not been elucidated. Here, we report that human protein is expressed in peripheral B and T lymphocytes acute lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing mouse expression CD4(+) increased during blast formation. Furthermore, ZFAT-knockdown induces apoptosis via activation of caspases. These results suggested critical...
TAL1 plays pivotal roles in vascular and hematopoietic developments through the complex with LMO2 GATA1. Hemangioblasts, which have a differentiation potential for both endothelial lineages, arise primitive streak migrate into yolk sac to form blood islands, where hematopoiesis occurs. ZFAT (a zinc-finger gene autoimmune thyroid disease susceptibility region / an immune-related transcriptional regulator containing 18 C 2 H -type domains one AT-hook) was originally identified as AT-hook, is...
Tespa1 has been recently reported to be a critical molecule in T-cell development, however, the precise molecular mechanisms of remain elusive. Here, we demonstrate that shows amino-acid sequence homology KRAS-induced actin-interacting protein (KRAP), an inositol 1,4,5-trisphosphate receptor (IP3R) binding protein, and physically associates with IP3R T B lymphocytes. Two-consecutive phenylalanine residues (Phe185/Phe186) Tespa1, which are conserved between KRAP, indispensable for association...