A5019584033- Inhalation and Respiratory Drug Delivery
- Stress Responses and Cortisol
- Neonatal Respiratory Health Research
- Particle Dynamics in Fluid Flows
- Tissue Engineering and Regenerative Medicine
- Respiratory Support and Mechanisms
- Aerosol Filtration and Electrostatic Precipitation
- Congenital Diaphragmatic Hernia Studies
- Quantum, superfluid, helium dynamics
- Air Quality and Health Impacts
- Health and Wellbeing Research
- Mental Health Research Topics
- Adipose Tissue and Metabolism
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Congenital heart defects research
- Behavioral Health and Interventions
- Psychological Well-being and Life Satisfaction
- Neuropeptides and Animal Physiology
- Health and Well-being Studies
- Receptor Mechanisms and Signaling
- Cancer Cells and Metastasis
- Lattice Boltzmann Simulation Studies
- Angiogenesis and VEGF in Cancer
- Preterm Birth and Chorioamnionitis
Harvard University
2013-2024
Kurume University
2013-2024
Teikyo University
2024
Teikyo University of Science
2022-2024
Harvard University Press
2010-2021
Kanazawa Institute of Technology
2019
Smith College
2019
Syracuse University
2019
University of Memphis
2019
Texas A&M University
2019
A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of lung adenocarcinoma. As expected, there was an abrupt decrease her vital capacity, but unexpectedly, it increased during the subsequent 15 years. Serial computed tomographic (CT) scans showed progressive enlargement remaining left and increase tissue density. Magnetic resonance imaging (MRI) with use hyperpolarized helium-3 gas overall acinar-airway dimensions that were consistent alveolar number rather than...
The objectives of this study were (1) to determine whether short-term exposures concentrated air particles (CAPs) cause pulmonary inflammation in normal rats and with chronic bronchitis (CB); (2) identify the site within lung parenchyma where CAPs-induced occurs; (3) characterize component(s) CAPs that is significantly associated development inflammatory reaction. Four groups animals studied: treated, filtered exposed (air-sham); sulfur dioxide treated (CB), (CB-sham); (air-CAPs); (4)...
ABSTRACT Aims To assess the prevalence of current tobacco smoking, associations with beliefs about health benefits not smoking and awareness risks for lung cancer heart disease in university students sampled from 23 countries, to explore utility World Health Organization (WHO) model world‐wide epidemic understanding differences between countries. Design Anonymous questionnaire survey. Participants A total 19 298 (8482 men, 10 816 women) aged 17–30 years studying courses unrelated health....
Activation of the innate immune system is commonly accompanied by a set behavioural, psychological and physiological changes known as 'sickness behaviour'. In animals, infection-related sickness symptoms are significantly increased exposure to psychosocial stress, suggesting that stressors may operate through similar pathways induce sickness. We used double-blind, randomised, placebo-controlled design examine effect acute stress on subjective mood responses typhoid vaccination in 59 men....
After delineating the roots of harmony in literature from both Eastern and Western perspectives, paper introduces new Psychology terms harmonization that widens perspective calling for psychological contributions regarding components, processes building strengths a preventive perspective. The complex construction Harmony underlines concept relationality. results at three main points, with oneself, others, nature/the natural world, also taking into account spatial temporal perspectives. as...
We examined the effects of rhythmic expansion alveolar walls on fluid mechanics in pulmonary acinus. generated a realistic geometric model an alveolated duct that expanded and contracted geometrically similar fashion to simulate tidal breathing. Time-dependent volumetric flow was by adjusting proximal distal boundary conditions. The low Reynolds number velocity field solved numerically over physiological range. found for given geometry, ratio (QA) ductal (QD) played major role determining...
The inhalation of micron-sized aerosols into the lung’s acinar region may be recognized as a possible health risk or therapeutic tool. In an effort to develop deeper understanding mechanisms responsible for deposition, we have numerically simulated transport nondiffusing fine inhaled particles (1 μm and 3 in diameter) two models varying complexity: (i) simple alveolated duct (ii) space-filling asymmetrical branching tree following description lung structure by Fung (1988, “A Model Lung...
In most rodents and some other mammals, the removal of one lung results in compensatory growth associated with dramatic angiogenesis complete restoration capacity. One pivotal mechanism neoalveolarization is neovascularization, because without new alveoli can not be formed. The aim this study to image analyze three-dimensionally different patterns neovascularization seen following pneumonectomy mice on a sub-micron-scale. C57/BL6 underwent left-sided pneumonectomy. Lungs were harvested at...
L-ornithine is a non-essential, non-protein amino acid. Although contained in various foods, the amount usually small. Recently, studies have shown that orally administered reduced stress response animals. From these findings, we speculated may play role relieve of and improve sleep fatigue symptoms humans. Through randomised, double-blind, placebo-controlled clinical study, asked if could be beneficial to healthy workers. Fifty-two apparently Japanese adults who had previously felt slight...
Our current understanding of the transport and deposition aerosols (viruses, bacteria, air pollutants, aerosolized drugs) deep in lung has been grounded dispersive theories based on untested assumptions about nature acinar airflow fields. Traditionally, these have taken to be simple kinematically reversible. In this article, we apply recently discovered fluid mechanical phenomenon irreversible low-Reynolds number flow lung. We demonstrate, through visualization studies rhythmically...
In a previous simulation, our laboratory demonstrated that the flow induced by rhythmically expanding and contracting alveolus is highly complex (Haber S, Butler JP, Brenner H, Emanuel I, Tsuda A, J Fluid Mech 405: 243–268, 2000). Based on these earlier findings, we hypothesize trajectories deposition of aerosols inside alveoli differ substantially from those previously predicted. To test this hypothesis, fine particles (0.5–2.5 μm in diameter) moving foregoing alveolar field simultaneously...
Current theories describe aerosol transport in the lung as a dispersive (diffusion-like) process, characterized by an effective diffusion coefficient context of reversible alveolar flow. Our recent experimental data, however, question validity these basic assumptions. In this study, we behavior fluid particles (or bolus) realistic, numerical, alveolated duct model with rhythmically expanding walls. We found acinar flow exhibiting multiple saddle points, characteristic chaotic flow, resulting...
Arterial occlusion is a leading cause of cardiovascular disease. The main mechanism causing vessel thrombus formation, which may be initiated by the activation platelets. focus this study on mechanical aspects platelet-mediated thrombosis includes motion, collision, adhesion and aggregation activated platelets in blood. A review existing continuum-based models given. model platelet accumulation onto wall developed using dissipative particle dynamics (DPD) method blood (i.e....
The alveolated structure of the pulmonary acinus plays a vital role in gas exchange function. Three-dimensional (3D) analysis parenchymal region is fundamental to understanding this structure-function relationship, but only limited number attempts have been conducted past because technical limitations. In study, we developed new image processing methodology based on finite element (FE) for accurate 3D structural reconstruction regions lung. Stereologically well characterized rat lung samples...
A series of three studies was performed to investigate the effects ability avoid or escape shock (controllability) and lack do so (uncontrollability) on noradrenergic neurons in various brain regions male Wistar rats. The levels noradrenaline (NA) its major metabolite, 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4), hypothalamus, amygdala, thalamus, midbrain, hippocampus, cerebral cortex, pons plus medulla oblongata, basal ganglia were measured fluorometrically. These indicated...
The past decade has seen significant increases in combustion-generated ambient particles, which contain a nanosized fraction (less than 100 nm), and even greater have occurred engineered nanoparticles (NPs) propelled by the booming nanotechnology industry. Although inhalation of these particulates become public health concern, human effects mechanisms action for NPs are not well understood. Focusing on airway smooth muscle cell, here we show that cellular mechanical function is altered...