A5102707267- Diabetes Management and Research
- Diabetes Treatment and Management
- Parathyroid Disorders and Treatments
- CO2 Sequestration and Geologic Interactions
- Bone health and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes and associated disorders
- Nitric Oxide and Endothelin Effects
- Electron Spin Resonance Studies
- Metabolism and Genetic Disorders
- Bone health and osteoporosis research
- Metabolism, Diabetes, and Cancer
- Enhanced Oil Recovery Techniques
- Hypothalamic control of reproductive hormones
- Adipokines, Inflammation, and Metabolic Diseases
- Photodynamic Therapy Research Studies
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hydraulic Fracturing and Reservoir Analysis
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Neuropeptides and Animal Physiology
- Bone Metabolism and Diseases
- Medical Imaging and Pathology Studies
Tohoku University Hospital
2025
University of Tokyo Hospital
2023
Kyoto University
2003-2022
The University of Tokyo
1993-2022
National Hospital Organization
2021
University of Occupational and Environmental Health Japan
2011-2020
Kyoto Prefectural University of Medicine
1997-2018
Kumamoto University Hospital
2018
The Ohio State University
2015-2018
Japanese Red Cross Hokkaido College of Nursing
2016
Abstract Background Fluctuations in blood glucose level cause endothelial dysfunction and play a critical role onset and/or progression of atherosclerosis. We hypothesized that fluctuation levels correlate with vascular this relationship can be assessed using common bedside medical devices. Methods were measured over 24 hours by continuous monitoring (CGM) on admission day 2 57 patients type diabetes mellitus. The reactive hyperemia index (RHI), an function, was peripheral arterial tonometry...
Epigenetic histone modifications are emerging as important mechanisms for conveyance of and maintenance effects the hormonal milieu to developing brain. We hypothesized that alteration acetylation status early in development by sex steroid hormones is sexual differentiation It was found during critical period differentiation, histones associated with promoters essential genes masculinization brain (estrogen receptor α aromatase) medial preoptic area, an area necessary male behavior, were...
MINT‐7301204, MINT‐7301186: RhoA (uniprotkb:P61586) physically interacts (MI:0915) with RAGE (uniprotkb:Q15109) by anti bait coimmunoprecipitation (MI:0006)
Abstract Introduction The aim of the present study was to determine effect sitagliptin on microalbuminuria in patients with type 2 diabetes mellitus. Materials and Methods A total 85 mellitus (age >20 years, <80 hemoglobin 1c [ H bA1c] <8.4%) were randomized taking 50 mg or other oral glucose‐lowering agents. following parameters evaluated at 0, 3 6 months after treatment: bodyweight, blood pressure, b 1c, fasting plasma glucose, insulin, low‐density lipoprotein cholesterol,...
Abstract Background Statins are used to treat hypercholesterolemia in patients with type 2 diabetes mellitus, but many of these fail achieve the target LDL-C level. Recent reports have suggested that a synergistic effect can be obtained by concomitant administration cholesterol absorption inhibitor ezetimibe and statin. However, who already being treated satins, it remains unclear whether is more effective add or increase statin dose. Therefore, this study was performed examine effects two...
Basic studies have shown that glucagon-like peptide-1 (GLP-1) analogs exert a direct protective effect on the vascular endothelium in addition to their indirect effects postprandial glucose and lipid metabolism. GLP-1 are also reported inhibit endothelial dysfunction. This study examined whether analog exenatide inhibits dysfunction patients with type 2 diabetes mellitus (T2DM).Seventeen T2DM underwent meal tolerance test examine changes function metabolism, both without (baseline) after...
A 44-year-old woman with iron deficiency anemia was on a continuous course of intravenous saccharated ferric oxide (SFO). She came to our hospital because right hip joint pain. found have hypophosphatemia caused by impaired phosphorus resorption and her fibroblast growth factor 23 (FGF-23) levels were elevated. Therefore, she diagnosed FGF-23-related osteomalacia due SFO administration. Discontinuation the treatment rapidly improved also normalized blood FGF-23. During SFO, it is important...
Abstract Introduction The aim of the present study was to determine actual state inter‐day glycemic variability and identify factors that affect in diabetic outpatients on insulin therapy. Materials Methods participants were 45 with diabetes mellitus receiving mean plasma glucose ( MPG ) levels, intra‐day (expressed by standard deviation amplitude excursion) daily differences [ MODD ] blood levels) measured continuously over 7 days iPro2 ® . primary outcome relationship between life index....
Effect of caffeic acid on the formation hydroxyl radicals was examined during xanthone-mediated photosensitization. The reaction performed irradiation (λ = 365 nm) standard mixture containing 15 μM xanthone, 0.1 M 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 20 mM phosphate buffer (pH 7.4) using electron paramagnetic resonance (EPR) with spin trapping. Caffeic inhibited radicals. hardly scavenged both superoxide under conditions employed in this paper spite its ability to act as a hydrogen...
A 54-year-old female underwent mastectomy in 1992 for breast cancer, but later developed liver metastasis 2004, which was treated with docetaxel a short period, and then discontinued due to nausea. Bone diagnosed 2005 the combination of trastuzumab zoledronate (4 mg/month) as well radiotherapy. Progressive hypokalemia renal dysfunction were observed since 2006 patient admitted our department 2009 further management (serum potassium 2.2 mEq/L) creatinine: 2.0 mg/dL). Accelerated excretion...
Vascular endothelial dysfunction is involved in macrovascular disease progression type 2 diabetes mellitus (T2DM). We reported previously that blood glucose fluctuations, as evaluated by continuous monitoring (CGM), correlate with vascular function, serving a marker of function. However, the use CGM limited, suggesting need for another Here, we investigated relationship between and levels 1,5-anhydro-D-glucitol (1,5-AG), both postprandial hyperglycemia fluctuations glucose.In 32 inpatients...
We performed a crossover study in hypertensive patients with type 2 diabetes to compare olmesartan (40 mg/day) telmisartan (80 terms of their antihypertensive and metabolic effects. The subjects were 36 (20 men 16 women) who did not achieve blood pressure <130/80 mmHg following treatment at 40 mg/day or 80 for 8 weeks more. primary endpoint was the reduction rate, while secondary endpoints BMI, parameters glucose metabolism, HMW-adiponectin, hs-CRP lipids metabolism. All measured Weeks 0,...
Localized fat collection adjacent to the intrahepatic portion of inferior vena cava: a normal variant on CT.H Miyake, K Suzuki, S Ueda, Y Yamada, H Takeda and MoriAudio Available | Share