A5045024120- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Prenatal Substance Exposure Effects
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Mesenchymal stem cell research
- Preterm Birth and Chorioamnionitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Infant Development and Preterm Care
- Prenatal Screening and Diagnostics
- Viral Infections and Immunology Research
- Platelet Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Autoimmune Bullous Skin Diseases
- EEG and Brain-Computer Interfaces
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroblastoma Research and Treatments
- Erythropoietin and Anemia Treatment
- Renal Diseases and Glomerulopathies
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Neonatal skin health care
Johns Hopkins University
2019-2024
Johns Hopkins Medicine
2019-2024
Nagoya University Hospital
2017-2023
Nagoya University
2016-2020
University of New Mexico
2020
Kennedy Krieger Institute
2020
Toyota Memorial Hospital
2016-2017
Anjo Kosei Hospital
2010
Perinatal hypoxic-ischemic (HI) brain injury occurs in 1 1000 live births and remains the main cause of neurological disability death term infants. Cytotherapy has recently emerged as a novel treatment for tissue injury. In particular, mesenchymal stem cells (MSCs) are thought to have therapeutic potential, but little is known about differences according their origin. current study, we investigated effects safety intravenous injection allogeneic bone marrow-derived MSCs (BM-MSCs)...
Infants with trisomy 18 (T18) previously had a poor prognosis; however, the intensive care of these patients has markedly diversified prognosis. We investigated current situation T18, clarified factors for survival discharge, and surveyed actual home healthcare. A total 117 T18 admitted to nine institutions between 2000 2015 were retrospectively investigated. After excluding four whose outcomes unclear, we divided 113 into two groups-the discharge group (n = 52) death 61)-and compared...
The opioid epidemic is an ongoing public health crisis, and children born following prenatal exposure (POE) have increased risk of long-term cognitive behavioral sequelae. Clinical studies identified reduced gray matter volume abnormal white microstructure in with POE but impacts on whole-brain functional brain connectivity (FC) not been reported. To define effects whole FC injury adult animals, we performed quantitative structural MRI. We used established rat model which previously reported...
The increased incidence of opioid use during pregnancy warrants investigation to reveal the impact exposure on developing fetus. Exposure critical periods development could have enduring consequences for affected individuals. Particularly, evidence is mounting that developmental injury can result in immune priming, whereby subsequent activation elicits an exaggerated response. This maladaptive hypersensitivity challenge perpetuates dysregulated inflammatory signaling and poor health...
Chorioamnionitis (CHORIO) is a principal risk factor for preterm birth and the most common pathological abnormality found in placentae of infants. CHORIO has multitude effects on maternal-placental-fetal axis including profound inflammation. Cumulatively, these changes trigger injury developing immune central nervous systems, thereby increasing susceptibility to chronic sequelae later life. Despite this reports neural-immune children with cerebral palsy, extent chronicity peripheral...
Opioid use during pregnancy continues to rise at alarming rates with a parallel trend in the number of infants and children exposed opioid medications each year. Prenatal exposure (POE) occurs critical timepoint neurodevelopment disrupting intricate pathways essential for neural-immune maturation potential devastating long-term consequences. Understanding mechanisms underlying injury associated POE is address outcomes identify diagnostic therapeutic biomarkers this vulnerable patient...
Recently, cell therapy has been developed as a novel treatment for perinatal hypoxic-ischemic encephalopathy (HIE), which is an important cause of neurological disorder and death, stem cells from human exfoliated deciduous teeth (SHED) express early markers mesenchymal neuroectodermal cells. We investigated the effect SHED HIE in neonatal rats. Seven-day-old rats underwent ligation left carotid artery were exposed to 8% hypoxic treatment. (1 × 105 cells) injected via right external jugular...
Intrauterine growth restriction (IUGR) resulting from hypertensive disease of pregnancy (HDP) leads to sexually dimorphic hippocampal-dependent cognitive and memory impairment in humans. In our translationally relevant mouse model IUGR incited by HDP, we have previously shown that the synaptic development dorsal hippocampus including GABAergic development, NPTX2+ excitatory formation, axonal myelination, perineural net (PNN) formation were perturbed at adolescent equivalence humans (P40)....
Multilineage-differentiating stress-enduring (Muse) cells are endogenous reparative pluripotent stem present in the bone marrow, peripheral blood, and organ connective tissues. We assessed homing therapeutic effects of systemically administered nafimestrocel, a clinical-grade human Muse cell-based product, without immunosuppressants neonatal hypoxic-ischemic (HI) rat model. HI injury was induced on postnatal day 7 (P7) confirmed by T2-weighted magnetic resonance imaging P10. rats received...
Fetal growth restriction (FGR) is a major complication of prenatal ischemic/hypoxic exposure and affects 5%–10% pregnancies. It causes various disorders, including neurodevelopmental disabilities due to chronic hypoxia, circulatory failure, malnutrition via the placenta, there no established treatment. Therefore, development treatments an urgent task. Our aim was develop new FGR rat model with gradual restrictive load uterus/placental blood flow evaluate treatment effect administration...
Abstract Preterm birth is a principal cause of neurological disability later in life, including cognitive and behavioral deficits. Notably, impairment has greater impact on quality life than physical disability. Survivors preterm commonly have deficits executive function. Difficulties with tasks planning complexity correlate positively increasing To overcome these barriers for children born preterm, preclinical clinical studies emphasized the importance neurorestoration. Erythropoietin (EPO)...
Chorioamnionitis (CHORIO), placental insufficiency, and preterm birth are well-known antecedents of perinatal brain injury (PBI). Heme-oxygenase-1 (HO-1) is an important inducible enzyme in oxidative inflammatory conditions. In the brain, HO-1 iron regulatory receptor, transferrin receptor-1 (TfR1), known to be involved homeostasis, stress, cellular adaptive mechanisms. However, role HO pathway pathophysiology PBI has not been previously studied. this study, we set out define ontogeny...
Cerebral palsy (CP) is the most common cause of physical disability for children worldwide. Many infants and toddlers are not diagnosed with CP until they fail to achieve obvious motor milestones. Currently, there no effective pharmacologic interventions available substantially improve their trajectory neurodevelopment. Because from preterm birth also exhibit a sustained immune system hyper-reactivity, we hypothesized that neuro-immunomodulation regimen repurposed endogenous neurorestorative...
Fetal growth restriction (FGR), followed by postnatal early catch-up growth, is associated with an increased risk of metabolic dysfunction, including type 2 diabetes in humans. This study aims to determine the effects FGR and after birth on pathogenesis diabetes, particular attention glucose tolerance, pancreatic islet morphology, fibrosis, elucidate its mechanism using proteomics analysis. The rat model was made inducing mild intrauterine hypoperfusion ameroid constrictors (ACs). On day 17...
Abstract Minimizing central nervous system (CNS) injury from preterm birth depends upon understanding the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. Signaling by chemokine (C‐X‐C motif) ligand 1 (CXCL1) through its cognate receptor, CXCR2 [(C‐X‐C receptor 2] is for neurodevelopment. Increased signaling, however, implicated in a variety of uterine neuropathologies, their role associated with perinatal brain poorly defined. To evaluate long‐term...
Rare progression to renal failure imposes a burden on children with IgA vasculitis (Henoch-Schönlein purpura, HSP). An abnormal urinalysis day 7 (7d-UA) may be surrogate marker for persistent nephritis, but this has not been established. We retrospectively analyzed the risk factors nephritis in cohort of 138 children. Of 35 7d-UA, 24 (69%) had an 6 months after diagnosis HSP, which was significantly more than 103 (6%) normal 7d-UA (P < 0.0001). The negative predictive values and proteinuria...