A5083803944- Congenital Heart Disease Studies
- Enzyme Catalysis and Immobilization
- Monoclonal and Polyclonal Antibodies Research
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Microbial Metabolic Engineering and Bioproduction
- Cardiac Valve Diseases and Treatments
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Congenital heart defects research
- Cardiovascular and Diving-Related Complications
- Occupational and environmental lung diseases
- Infective Endocarditis Diagnosis and Management
- T-cell and B-cell Immunology
- Biofuel production and bioconversion
- Tracheal and airway disorders
- Cell Adhesion Molecules Research
- Cardiovascular Function and Risk Factors
- Allergic Rhinitis and Sensitization
- Aortic aneurysm repair treatments
- Inhalation and Respiratory Drug Delivery
- Infection Control and Ventilation
- Cynara cardunculus studies
- Traumatic Ocular and Foreign Body Injuries
Nagoya University Hospital
2023-2024
Toyota Motor Corporation (Switzerland)
2024
Nagoya University
1992-2023
Chukyo Hospital
2016
Japan Community Healthcare Organization
2016
Nagasaki Rousai Hospital
1999-2015
Yamaguchi University
2013-2014
Toyota Memorial Hospital
2011
Edogawa Hospital
2007
Daicel (Japan)
2004
Percutaneous occlusion of atrial septal defect (ASD) has recently become a standard therapeutic strategy, but little is known about left (LA) function thereafter. The present study aimed to determine LA in 43 children with ASD and 13 controls based on strain measured by two-dimensional echocardiographic speckle tracking (2DE-ST). Among these children, 12 underwent surgery (ASD-S), 31 had device closure (ASD-D), were included as controls. was significantly decreased after ASD-D not altered...
Glycerol dehydrogenase (EC 1.1.1.6) was purified from a methylotrophic yeast, Hansenula polymorpha DL-1, for the characterisation and identification of its function. The yeast grown in glycerol medium. SDS-PAGE gel permeation chromatography showed enzyme to be composed two subunits, each with molecular mass 36,000. optimum pH oxidation 10. temperature activity 30 °C. CuCl2, HgCl2, FeCl3 were severely inhibitory. decreased 0% by 1 mM 2, 2′-dipyridyl o-phenanthroline, which are inhibitors...
Abstract Background Many small for gestational age ( SGA ) infants have catch‐up growth during the first 2 years of life, but approximately 10% no growth, and short stature continues into adulthood. Identification risk factors absence at an early may be useful earlier diagnosis treatment. Methods This was a retrospective multicenter study. The subjects were with very low‐birthweight VLBW ), who followed up until 3 years. identified on statistical analysis. Results Of 217 in this study, 181...
Abstract: An apparatus for the non‐culture method (NCM) of microbial cell count was formerly developed and named a bioplorer. The bioplorer NCM is based on double staining cells with 4′, 6‐diamidino‐2‐phenylindole (DAPI) propidium iodide (PI) automatic analysis their fluorescent microscopic images. Viable can be stained DAPI, while dead DAPI PI. In this study, has been applied to dialysate. viable in dialysate could counted within 20 min. detection limit expressed by log 10 [cells/100 mL]...
Pulmonary hypertension (PH) with developmental lung disease is a life-threatening and accounts for 10%–12% of pediatric PH patients. Administration specific pulmonary vasodilators to patients has brought about improvement their long-term prognosis. Intravenous epoprostenol therapy gold standard severe idiopathic arterial (IPAH), but there are few reports demonstrating the efficacy disease, especially when treating high doses epoprostenol. Two cases alveolar capillary dysplasia misalignment...
This study investigated the potential application of pressurized CO2 for water disinfection. Under supporting high pressure, a volume microbubbles were produced in liquid environment. Specifically, inactivation effects against Escherichia coli, bacteriophage MS2 and T4 examined at equal pressures (0.3 - 0.9 MPa) temperatures. The optimum conditions found to be 0.7 MPa an exposure time 25 min. identical treatment conditions, greater than 5.0 log reduction E. coli was achieved, while over 3.0...
Abstract Chiral alcohols are useful as intermediates for the synthesis of drugs. In production chiral alcohols, microbial enzymes promising since high optical purity is required. Under these conditions, reaction by resting cells more convenient and inexpensive than an enzyme reaction. 1,2‐propanediol 2,3‐butanediol were obtained using expressing which demonstrated stereospecificity. By means recombinant glycerol dehydrogenase Hansenula polymorpha DL‐1, medium was enriched with ( S...
Abstract Hereditary connective tissue diseases have different risks of aortic dissection depending on the causative gene. We report a family with no extravascular phenotype and clinical diagnosis familial thoracic aneurysm dissection, but genetic testing confirmed p.Tyr470Cys in TGFBR2 , which is typically responsible gene for Loeys–Dietz syndrome. Validation by warranted.
背景：主肺動脈の狭窄や閉鎖を伴う多くのチアノーゼ性心疾患では，上行大動脈の拡大と弓下の空間の狭小化が見られ根治術を困難にする．この問題に対する手術方法として，自己大動脈組織によるaortic extension法を考案した．
Abstract Optically active alcohols are important building blocks as versatile chiral synthons for asymmetric syntheses of pharmaceuticals and agrochemicals. The aim this paper is to efficiently prepare 2‐pentanol by means microorganisms. gene dihydroxyacetone reductase (EC 1.1.1.6) from a methylotrophic yeast, Hansenula ofunaensis, was cloned produced the recombinant Escherichia coli harboring gene. encoding enzyme an H. ofunaensis genomic library. In deduced amino acid sequence 364...
Abstract A 14-year-old girl suddenly developed ventricular tachycardia and severe chest pain during hospitalisation for trauma surgery. CT revealed a needle in the pericardium. Careful interview elicited that she had inserted by herself, Munchausen syndrome was diagnosed. This is first report of caused foreign body patient with syndrome.
<b>Background:</b> There is no gold standard sedation method for pediatric cardiac catheterization. In congenital heart diseases with intracardiac shunts, hemodynamic parameters are prone to change depending on the ventilation conditions and anesthetics, although few studies have examined these effects. The purpose of this study was investigate effects two different methods parameters. <b>Methods:</b> This retrospectively evaluated consecutive patients ventricular septal defect (VSD) below 1...
The effects of 66 % hepatic congestion (group 2, n = 6) on liver blood flow and oxygen metabolism were investigated in anesthetized dogs using an ultrasonic transit time flowmeter. results compared with those for control 1, 60% hepatectomized 3, wherein almost the same amount parenchyma was removed as congested group 2. Portal (PVF) 2 3 decreased similarly to 60 63 baseline values, respectively (p < 0.05). Cardiac output (CO) also significantly proportion decrease PVF. Among arterial (HAF)...
Abstract A pregnant woman was referred to our hospital due fetal cardiomegaly. We recognised a dilated umbilical vein, which raised suspicion of placental chorioangioma. male neonate delivered at 37 weeks gestation. The cardiomegaly gradually improved. Pathological examination identified five non-giant chorioangiomas. Multiple chorioangiomas may cause complications despite the difficulty prenatal diagnosis.
Immunization of BALB/c mice with MOPC104E myeloma protein induces antiidiotypic B lymphocytes that have Id-specific enhancing activity on antibody production. The B-B cell interaction was restricted to both Igh and class II MHC. However, anti-Thy-1 C-treated splenic cells were maintained for more than 1 y in a mixture Con A-stimulated splenocyte culture supernatant synthetic medium. In applying the long term method, we established cloned line named B19-1d, B19-1d are specific or J558...
An agalmatolite miner and processor showed large shadows at the bilateral hila accompanied by surrounding emphysematous changes irregular on chest X-ray films. Chest CT scans were characterized a mixture of tiny structures small round opacities. Histopathological examination revealed massive fibrosis, which corresponded to shadows, but only number typical silicotic nodules, indicating mixed dust pneumoconiosis. Mineralogical autopsy lungs quartz, pyrophyllite, mica, kaolinite. Quartz...
The aim of this study was to investigate the prediction postnatal prognosis using fetal and perinatal data in patients with primary congenital dilated cardiomyopathy (PCDCM), estimate incidence disease.We examined correlations between or clinical course a multicenter retrospective eight PCDCM. Incidence calculated population-based study.All developed heart failure at median 8 days (range, 0-43 days), six died required extracorporeal artificial therapy 67 0-92 days). cardiothoracic area ratio...