To investigate whether there may be differences in the clinical course and changes cognitive progression between dementia with Lewy bodies (DLB) Alzheimer's disease (AD).We compared time from first visit to endpoints (discontinuation of visits because admission, death, or institutionalization) 56 patients DLB 111 AD. Mini-Mental State Examination (MMSE) scores were every 12 months examined up 60 months.Dementia had a significantly shorter reaching than those AD (median time; 40 vs. 52...

Recent studies have shown an association between rapid eye movement sleep behavior disorder (RBD) and neurodegenerative disorders, especially alpha-synucleinopathies.We investigated regional cerebral blood flow (rCBF) changes using single photon emission computed tomography (SPECT) in patients with idiopathic RBD (iRBD), to determine functional brain alterations associated the disorder.The SPECT data of 24 iRBD were compared those 18 age-matched normal controls statistical parametric mapping...

Background and purpose: Shortened telomere length has been considered to be associated with various age‐related diseases, especially in dementia such as Alzheimer’s disease vascular dementia. However, changes Lewy bodies (DLB) remain unclear. To elucidate these changes, we set out determine peripheral leukocytes well the level of urinary 8‐hydroxy‐deoxyguanosine (8‐OHdG) a marker oxidative stress DLB. Methods: Blood samples were obtained from 33 patients clinical diagnosis probable DLB 35...

The effects of estradiol (E2) and E2 withdrawal on tissue concentrations GnRH receptor mRNA were assessed in orchidectomized sheep (wethers). Wethers received (in 20% ethanol-saline [vehicle]) by continuous infusion at rates 0.31, 1.25, 5, or 20 micrograms/h (n = 12 animals per group). Control vehicle alone. Anterior pituitary was collected the end 48-h period. Steady-state levels quantified solution hybridization. Tissue significantly increased above control (0.5 +/- 0.1 pg/microgram RNA)...

The effect of implants containing anabolic steroid (Synovex®) on testis function, feedlot performance, and carcass traits was evaluated in bulls, steers, bulls actively immunized against gonadotropin-releasing hormone (GnRH). Ninety-one Hereford or × Red Angus bull calves were randomly assigned to a 3 2 factorial experiment. treatments 1) unimmunized control (n =30), 2) GnRH = 31), 3) castrate =30). classes unimplanted 45) implanted =46) with Synovex. Animals treatment Groups either...

The effect of stress-like concentrations cortisol (C) on the feedback potency estradiol (E2) was assessed using 32 orchidectomized sheep (wethers) assigned at random to 1 4 treatment groups in a 2 x factorial design. Wethers received C (3. 6 mg/50 kg per hour; and 4) or comparable volume delivery vehicle (groups 3) as continuous infusion for 7 days. During final 48 h infusion, wethers E2 (0.3 microg/50 kg/h; 3 2). pattern LH secretion during 4-h period intensive blood collection beginning 44...

Testes function, feedlot performance, and carcass traits were evaluated in bulls actively immunized against gonadotropin-releasing hormone (GnRH) at different ages. Bull calves randomly assigned to one of seven treatment groups (n = 15 calves/group). Calves unimmunized (Group 1), 1.5, 4, 7, or 12 mo age with a GnRH-keyhole limpet hemocyanin (KLH) conjugate (Groups 2 5, respectively), castrated 4 6 7). Immunized did not receive secondary, booster, immunization. group received Synovex-C...

The pattern of GnRH-like stimuli capable inducing follicular growth, ovulation, and luteal function was evaluated in ewes passively immunized against GnRH. estrous cycles 30 regularly cyclic sheep were synchronized using vaginal pessaries impregnated with a synthetic progestogen. Animals GnRH (groups 2–5, n = 6) or the carrier protein, keyhole limpet hemocyanin (KLH; group 1, 6), at time pessary removal (PR). Circhoral delivery saline 2, 5) low amplitude agonist (des-Gly10 ethylamide [100...

We investigated changes in water diffusion the cerebral white matter of 14 patients with vascular dementia Binswanger type (VDBT) and ten Alzheimer's disease (AD) periventricular hyperintensity (PVH) lesions using diffusion-weighted magnetic resonance imaging (MRI) studied pathophysiological differences between found these two conditions. Apparent coefficients (ADCs) anterior posterior genu splenium corpus callosum were significantly higher both groups than 12 age-matched controls, ADC...

The effect of stress-like concentrations cortisol (C) on estrogen-dependent expression GnRH receptor was evaluated using orchidectomized sheep (wethers; n = 6 animals per group). C (5.0 mg/50 kg hour; groups 1–4) or a comparable volume vehicle (groups 5–8) delivered by continuous infusion for 48 h. During the final 24 h infusion, received concurrent estradiol (E2) at rates 0 1 and 5), 0.5 2 6), 2.0 3 7), 8.0 4 8) μg/50 hour. Pituitary tissue collected end infusion. Although did not affect (p...

Stress-like concentrations of cortisol increase the negative feedback potency oestradiol in castrated male sheep. A similar cortisol-dependent response female sheep might be expected to suppress gonadotrophin secretion and impair follicular development ovulation. The oestrous activity 21 was synchronized using progestogen-treated vaginal pessaries test this hypothesis. (60–70 ng ml−1) were established by continuous infusion (80 μg kg−1 h−1; n = 13) beginning 5 days before, continuing for...

Atrial tachyarrhythmias are frequent complications in the late period after Fontan procedure, and important risk factors for a poor prognosis. The impact of conversion arrhythmia surgery failed patients has been described many reports.We evaluated our experience with procedures, concomitant surgery, pacemaker implantation.We reviewed hospital records 25 consecutive who underwent procedure from January 2004 to March 2012. Twenty-four had using cryoablation radiofrequency ablation at time...

Percutaneous occlusion of atrial septal defect (ASD) has recently become a standard therapeutic strategy, but little is known about left (LA) function thereafter. The present study aimed to determine LA in 43 children with ASD and 13 controls based on strain measured by two-dimensional echocardiographic speckle tracking (2DE-ST). Among these children, 12 underwent surgery (ASD-S), 31 had device closure (ASD-D), were included as controls. was significantly decreased after ASD-D not altered...

Bilateral pulmonary artery banding (bil-PAB) has been developed as a part of hybrid procedure for hypoplastic left heart syndrome (HLHS). We use this palliation complex congenital disease, particularly in patients with arch anomaly. reviewed our experience bil-PAB.Sixty-six consecutive cases between 2003 and 2014 were retrospectively.Fifty-one (77%) had single ventricle physiology (HLHS: 37, HLHS variant: 13, others: 1). Twelve biventricular [5 interrupted aortic ventricular septal defect...

The effect of immunoneutralization gonadotropin-releasing hormone (GnRH) on LH secretion and concentrations GnRH receptor, receptor mRNA, gonadotropin subunit mRNA in pituitary tissue orchidectomized sheep (wethers) was assessed. Thirty-six wethers were assigned at random to one six treatment groups (six per group). Thirty (groups 2 6) received 200 ml, (i.v.) anti-GnRH antisera passive immunization (PI). Anterior collected .5, 1, 2, 4, or 8 d after PI from 6, respectively. Pituitary also...

The effect of nutrient restriction on serum concentrations the gonadotropins, pattern LH secretion, and sensitivity to estradiol (E2) was assessed in orchidectomized sheep (wethers). Thirty-six wethers (initial weight = 42.3 ± 0.6 kg) were fed gain, maintain, or lose body (feeding groups G, M, L, respectively; n 12 wethers/group). After 7 wk controlled feeding, L weighed 57.0 1.7, 42.5 0.6, 36.6 0.8 kg, respectively. At end FSH M significantly higher than levels G wethers. During Days 51-54...

Abstract The effect of progesterone (P 4 ) and P withdrawal on oestradiol (E 2 )-induced change in gonadotrope responsiveness (GR) concentration GnRH receptor mRNA pituitary tissue orchidectomized sheep (wethers) was determined. Thirty wethers were assigned at random to one six treatment groups ( n =5 animals/group). Wethers received E (2 μg/h; 2, 4, 6) 10% ethanol-saline (vehicle), or vehicle alone (groups 1, 3, 5), as a continuous infusion for 24 h beginning 7 days after insertion (s.c.)...

The results of treatment 141 patients with stage III non-small cell lung cancer (NSCLC) who received definitive radiation therapy at Gunma University Hospital between 1976 and 1989 were retrospectively analyzed. Radiation was given standard fractionation for a planned prophylactic dose 40 Gy over 4 weeks 60 6 or more. two- five-year survival rates 27% 12% IIIA, 18% 8% IIIB, respectively (P = 0.052). By univariate analysis, primary tumor less than 5 cm in diameter also an important predictor...

To evaluate the operative result and perioperative management of dialysis patients undergoing elective cardiac surgery, we retrospectively reviewed consecutive adult with chronic renal failure dependent on maintenance dialysis. Between April 1994 March 2002, 20 who underwent cardiopulmonary bypass (CPB) procedures were studied. Fourteen isolated coronary artery grafting, four valve replacements two combined procedures. Our strategy for was as follows: day before operation, intraoperative...