A5037009613- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Nutrition and Health in Aging
- Cerebrovascular and Carotid Artery Diseases
- Frailty in Older Adults
- Neurological and metabolic disorders
- Medical Imaging Techniques and Applications
- Memory and Neural Mechanisms
- Cerebrovascular and genetic disorders
- Neurological disorders and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Sleep and Wakefulness Research
- MRI in cancer diagnosis
- Cognitive Functions and Memory
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- 14-3-3 protein interactions
Tokyo Medical University
2015-2024
JR Tokyo General Hospital
2021-2024
Southern Tohoku General Hospital
2024
Tokyo Medical University Hospital
2018-2019
Tokyo Medical University Hachioji Medical Center
2017
Banner Sun Health Research Institute
2013
Asahikawa Medical College Hospital
1998
Tachikawa Hospital
1993
The effectiveness and safety of yokukansan (TJ-54), a traditional Japanese medicine (kampo) for the treatment behavioural psychological symptoms dementia (BPSD), were evaluated in 106 patients diagnosed as having Alzheimer's disease (AD) (including mixed-type dementia) or with Lewy bodies. Patients randomly assigned to group A (TJ-54 period I no II; each lasting 4 wk) B (no TJ-54 II). BPSD cognitive functions using Neuropsychiatric Inventory (NPI) Mini-Mental State Examination (MMSE),...
Although sarcopenia is closely linked to dementia, particularly Alzheimer disease (AD), there are few studies examining the prevalence and associated factors of in subjects with AD. This study aimed investigate sarcopenia, elderly AD, differences muscle functions upper lower extremities gait speed at various stages We evaluated handgrip knee extension strength, mass, 285 outpatients probable AD (mean age 82.0 ± 5.3 years), including early (n = 82), mild 90), moderate 113), 67 normal...
Background and Purpose Dementia with Lewy bodies (DLB) needs to be distinguished from Alzheimer’s disease (AD) because of important differences in patient management outcome. Severe cardiac sympathetic degeneration occurs DLB, but not AD, offering a potential system for biological diagnostic marker. The primary aim this study was investigate the accuracy, ante-mortem differentiation probable DLB imaging ligand 123I-meta-iodobenzylguanidine (MIBG) which binds noradrenaline reuptake site,...
Aim: It remains unknown whether antiplatelet agents have a preventive effect on cognitive decline in patients with Alzheimer's disease (AD). We investigated the effects of cilostazol, an agent and cyclic adenosine monophosphate phosphodiesterase 3 inhibitor, cognition regional cerebral blood flow (rCBF) elderly AD cerebrovascular (CVD). Methods: A total 20 CVD were randomly assigned to cilostazol group ( n = 11, 100 mg daily) or control 9, aspirin clopidogrel 50 mg–75 for 6 months. Results:...
Aim: Recent studies have shown that some antihypertensive medications are associated with a significant reduction in the incidence of Alzheimer's disease (AD). However, it remains uncertain whether drugs may preventive effect on cognitive decline patients AD. We investigated effects telmisartan, an angiotensin II type 1 receptor blocker peroxisome proliferator‐activated γ‐stimulating activity, cognition and regional cerebral blood flow (rCBF) elderly hypertensive Methods: A total 20 probable...
Aims Dementia is closely connected with frailty, and these two conditions are common in older adults. However, the biological mechanism that causes frailty patients Alzheimer's disease (AD) not fully understood. We determined whether oxidative stress inflammatory mechanisms could be associated physical AD. Methods studied 140 elderly outpatients mild‐to‐moderate Frailty status was according to presence of following five measurable characteristics: weight loss, exhaustion, low activity,...
123I-2β-Carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) dopamine transporter single photon emission computed tomography (DAT SPECT) and 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy can be used to assist in the diagnosis of patients with dementia Lewy bodies (DLB). We compared diagnostic value these two methods differentiating DLB from Alzheimer’s disease (AD). Furthermore, we evaluated whether a combination DAT SPECT MIBG would provide more useful...
Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using well-characterized Japanese sample set, comprising 2,190 late-onset AD (LOAD) cases and 2,498 controls. genotyped 10 (Q33X, Y38C, R47H, T66M, N68K, D87N, T96K, R98W, H157Y, L211P) reported by Guerreiro et al. (2013) means the TaqMan dideoxy sequencing methods. Only three variants, L211P, were polymorphic (range minor allele...
To investigate whether there may be differences in the clinical course and changes cognitive progression between dementia with Lewy bodies (DLB) Alzheimer's disease (AD).We compared time from first visit to endpoints (discontinuation of visits because admission, death, or institutionalization) 56 patients DLB 111 AD. Mini-Mental State Examination (MMSE) scores were every 12 months examined up 60 months.Dementia had a significantly shorter reaching than those AD (median time; 40 vs. 52...
Background and purpose We previously reported the usefulness of iodine-123 metaiodobenzylguanidine ( 123 I-MIBG) myocardial scintigraphy for differentiation dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) in a cross-sectional multicentre study. The aim this study was, by using reassessed diagnosis after 3-year follow-up, to evaluate diagnostic accuracy I-MIBG probable DLB AD. Methods undertook follow-up 133 patients or possible AD who had undergone at baseline. An independent...
Aim The present study aimed to: (i) examine the reliability and validity of Dementia Assessment Sheet for Community‐based Integrated Care System 21‐items classifying patients to appropriate categories glycemic targets in older patients; (ii) develop a short version tool its validity. Methods A total 410 individuals were recruited this multicenter cross‐sectional study. We classified them into three used determining target Japan based on cognitive functions activities daily living....
We investigated the changes in water diffusion cerebral white matter 19 patients with Alzheimer's disease (AD), including 11 without and 8 periventricular hyperintensity (PVH) lesions, using diffusion-weighted magnetic resonance imaging (MRI). The apparent coefficients anterior posterior were significantly higher AD than 10 age-matched controls. PVH those without. anisotropic ratios, defined as restricted perpendicular to direction of nerve fibers, patients, even PVH, Our results suggest...
We compared regional cerebral blood flow (CBF) patterns in patients with dementia Lewy bodies (DLB) and Alzheimer’s disease (AD) using single photon emission computed tomography (SPECT) investigated the diagnostic utility of SPECT study differentiating between DLB AD. data on 20 75 AD were analyzed three-dimensional stereotactic surface projections. Regional CBF reduction was determined by quantitative analysis extraction estimation method. The group showed a significant temporoparietal,...