A5058408729- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Frailty in Older Adults
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Epilepsy research and treatment
- Medical Imaging Techniques and Applications
- Nutrition and Health in Aging
- Cerebrospinal fluid and hydrocephalus
- Diet and metabolism studies
- Sleep and Wakefulness Research
- Family Caregiving in Mental Illness
- Advanced Glycation End Products research
- Advanced MRI Techniques and Applications
- Cerebrovascular and genetic disorders
- Circadian rhythm and melatonin
- Neonatal Health and Biochemistry
Tokyo Medical University Hospital
2024
Tokyo Medical University
2015-2024
National Institute for Japanese Language and Linguistics
2024
National Center For Child Health and Development
2023
Maebashi Red Cross Hospital
2021-2022
Gunma University
2022
University of California, San Francisco
2008-2010
San Francisco VA Medical Center
2009-2010
Seikei University
2009
Although sarcopenia is closely linked to dementia, particularly Alzheimer disease (AD), there are few studies examining the prevalence and associated factors of in subjects with AD. This study aimed investigate sarcopenia, elderly AD, differences muscle functions upper lower extremities gait speed at various stages We evaluated handgrip knee extension strength, mass, 285 outpatients probable AD (mean age 82.0 ± 5.3 years), including early (n = 82), mild 90), moderate 113), 67 normal...
Aims Dementia is closely connected with frailty, and these two conditions are common in older adults. However, the biological mechanism that causes frailty patients Alzheimer's disease (AD) not fully understood. We determined whether oxidative stress inflammatory mechanisms could be associated physical AD. Methods studied 140 elderly outpatients mild‐to‐moderate Frailty status was according to presence of following five measurable characteristics: weight loss, exhaustion, low activity,...
123I-2β-Carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) dopamine transporter single photon emission computed tomography (DAT SPECT) and 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy can be used to assist in the diagnosis of patients with dementia Lewy bodies (DLB). We compared diagnostic value these two methods differentiating DLB from Alzheimer’s disease (AD). Furthermore, we evaluated whether a combination DAT SPECT MIBG would provide more useful...
We compared regional cerebral blood flow (CBF) patterns in patients with dementia Lewy bodies (DLB) and Alzheimer’s disease (AD) using single photon emission computed tomography (SPECT) investigated the diagnostic utility of SPECT study differentiating between DLB AD. data on 20 75 AD were analyzed three-dimensional stereotactic surface projections. Regional CBF reduction was determined by quantitative analysis extraction estimation method. The group showed a significant temporoparietal,...
Although several reports suggest that Alzheimer's disease (AD) is associated with shortened telomere length, the clinical relevance of this has not yet been fully elucidated. This study was conducted to clarify correlation length characteristics and ApoE phenotypes in 74 AD patients. Telomere determined from genomic DNA extracted whole blood by quantitative real-time polymerase chain reaction. We found no significant difference between non-dementia elderly control (n = 35) groups....
We attempted to define possible subgroups of Alzheimer's disease (AD) associated with diabetes mellitus (DM) based on brain imaging.We classified 175 patients clinically diagnosed AD and type 2 DM into 4 the basis presence or absence cerebrovascular (CVD) MRI (CVD no CVD) posterior cerebral hypoperfusion SPECT (AD pattern pattern). Differences in clinical characteristics among were examined.The subgroup showing neither a CVD nor an had significantly older age, higher hemoglobin A1c level,...
We aimed to assess the utility of AT(N) classification in clinical practice. measured cerebrospinal fluid levels amyloid-β (Aβ) 42, Aβ40, phosphorylated tau, total and neurofilament light chain (NfL) samples from 230 patients with Alzheimer's syndrome (ACS) 328 non-ACS. The concordance two A-markers (i.e., Aβ42 alone Aβ42/Aβ40 ratio) was not significantly different between ACS (87.4%) non-ACS (74.1%) groups. However, frequency discordant cases AAβ42-alone+/AAβ-ratio- higher (23.8%) than...
Aims We determined whether the possible roles of oxidative stress differ in pathophysiology and cognitive decline A lzheimer's disease ( AD ), vascular dementia VaD ) mixed lzheimer's/vascular MD ). Methods measured levels diacron reactive oxygen metabolite (d ROM reflecting amount organic hydroperoxides, biological anti‐oxidant potential (BAP), measuring ferric reducing ability blood plasma, 72 patients with , 27 24 53 non‐demented outpatients (control group). In addition, endogenous plasma...
To determine whether providing education to caregivers of patients with dementia decreases their depression symptoms and burden.Eighty-three outpatients being treated at the Memory Clinic Tokyo Medical University Hospital were enrolled. Forty-seven enrolled in caregivers' (EDU) group 36 control (CTL) group. Caregivers assessed for depression, burden, quality life (QoL). Patients cognition, psychological symptoms, QoL. Assessments carried out baseline 3 months (3M). EDU received lectures on...
Reduction in cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake is a characteristic feature of Parkinson's disease (PD) and dementia with Lewy bodies (DLB), useful distinguishing them from other neurodegenerative disorders. The aim this study was to investigate the role method scintigraphy differential diagnosis our Memory Clinic. We performed MIBG patients referred Clinic compared heart-to-mediastinum (H/M) ratio uptake. Thirty out 32 DLB all 9 PD had reduced H/M ratios, whereas 37 40...
Treatment with acetylcholinesterase inhibitors (AchEIs) is beneficial for patients Alzheimer's disease (AD). But the clinical response varies. Functional neuroimaging techniques might allow objective evaluation of topographic correlates effect therapy on brain functioning. We attempted to evaluate possible correlation between regional cerebral blood flow (rCBF) differences in AD and donepezil hydrochloride (Donepezil) therapy.The subjects this study were 51 consecutive receiving Donepezil...
<i>Background/Aims:</i> To investigate neuroanatomical substrates of unawareness memory deficits in patients with early Alzheimer’s disease (AD). <i>Methods:</i> We compared regional perfusion between AD awareness (n = 19) and 19). SPECT data were analyzed by statistical brain imaging method. <i>Results:</i> Statistical maps demonstrated a more extensive severe reduction the unaware group than aware group. Quantitative analysis significant difference...
Background:Recently, many studies have investigated the association between orexin A and Alzheimer's disease (AD). However, it remains to be determined whether observed changes in levels are associated with pathological underlying AD, or cognitive function. In particular, a dir ect cerebrospinal fluid (CSF) function has not been reported date. Objective:The aim of this study was identify there is direct orexinergic system AD. Methods:For study, we included 22 patients AD 25 control subjects...
The aim of this study was to determine if a dissociation between reduced cerebral perfusion and gray matter (GM) atrophy exists in frontotemporal dementia (FTD). included 28 patients with FTD 29 cognitive normal (CN) subjects. All subjects had MRI at 1.5 T, including T1-weighted structural arterial spin labeling (ASL) imaging. Non-parametric concordance/discordance tests revealed that GM without hypoperfusion occurs the premotor cortex whereas concordant changes are found right prefrontal...
<b><i>Background/Aims:</i></b> The present study evaluated the differences in treatment outcomes and brain perfusion changes among 3 types of acetylcholinesterase inhibitors (AchEIs, i.e. donepezil, rivastigmine, galantamine). <b><i>Methods:</i></b> This was a prospective, longitudinal, randomized, open-label, 3-arm (donepezil, or galantamine), parallel-group, 12-month clinical trial carried out 55 patients with AD....