A5027178556- Cancer Immunotherapy and Biomarkers
- Platelet Disorders and Treatments
- Renal cell carcinoma treatment
- Blood groups and transfusion
- Bladder and Urothelial Cancer Treatments
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Complement system in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Mast cells and histamine
- Oral and Maxillofacial Pathology
- Botulinum Toxin and Related Neurological Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Blood disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Pain Mechanisms and Treatments
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Renal and related cancers
- Sarcoma Diagnosis and Treatment
- Robotic Locomotion and Control
- MRI in cancer diagnosis
- Infective Endocarditis Diagnosis and Management
- Prosthetics and Rehabilitation Robotics
Aichi Medical University Hospital
2016-2024
Aichi Medical University
2013-2024
Osaka Institute of Technology
2009-2024
Saitama Medical University
2023-2024
Social Insurance Saitama Chuo Hospital
2023-2024
National Cancer Center Hospital East
2021-2024
Chiba Cancer Center
2021-2022
National Cancer Centre Japan
2022
Nagoya University Hospital
2014-2021
Japanese Red Cross Society, Japan
2021
Multiple myeloma in humans is frequently associated with mast cell infiltration and neovascularization, which correlate directly disease severity, but the mechanisms underlying this relationship remain unclear. Here, we report that primary murine cells express angiopoietin-1 (Ang-1) low levels of VEGF-A not Ang-2 2 established plasmacytoma lines high little or no Ang-1 Ang-2. An vivo angiogenesis assay using extracellular matrix components shows cells, together, promote marked...
Stressors contribute to thrombosis and insulin resistance. Since obesity-related adipose inflammation is also involved in these pathological states, we assumed that stress correlates with inflammation. Male mice were subjected 2-week intermittent restraint stress. Expression of plasma lipids, monocyte/macrophage markers (CD11b, CD68, F4/80), proinflammatory cytokines (monocyte chemoattractant protein-1 [MCP-1], tumor necrosis factor-α, interleukin-6), adiponectin, heat shock protein 70.1...
Abstract Mast cells (MCs) are common components of inflammatory infiltrates and a source proangiogenic factors. Inflammation is often accompanied by vascular changes. However, little known about modulation MC-derived factors during inflammation. In this study, we evaluated the effects proinflammatory mediator prostaglandin E2 (PGE2) on MC expression release We report that PGE2 dose-dependentlyinduces primary MCs to chemokine monocyte chemoattractant protein-1 (MCP-1). This MCP-1 complete 2 h...
Abstract Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and thromboembolism, but mechanisms remain elusive. We reported recently that targets visceral adipose tissue (VAT), inducing lipolysis, low-grade inflammation with production of inflammatory adipokines, derangements such as insulin resistance, prothrombotic state. In present study, we hypothesized involvement VAT xanthine oxidoreductase (XOR), a source reactive oxygen species (ROS) uric acid (UA) in...
Abstract Background Nivolumab is an immune checkpoint inhibitor specific to the programmed death 1 (PD-1) receptor. has shown clinical responses in many malignancies. Although immune-related adverse events (irAEs) associated with nivolumab are largely tolerable, severe irAEs have occurred some patients. However, mechanisms underlying development of not fully clarified. Case presentation We report 2 patients metastatic melanoma who developed colitis, caused by nivolumab. Both experienced...
The membranes of single-cell organisms are crucial as the first line defense. outer membrane Gram-negative bacteria is an asymmetric bilayer in which lipopolysaccharides (LPSs) and phospholipids localized inner leaflet, respectively. This asymmetry important for integrity. In Escherichia coli, Mla transport pathway maintains this by removing from leaflet. MlaD component system a mammalian cell entry (MCE) domain protein, E. coli has two other MCE proteins unknown function (PqiB YebT). Here,...
Hypophosphatasia has been reported to develop nephrocalcinosis, renal stone, and chronic kidney failure. We investigated their impairments in the adults with hypophosphatasia know phenotype-genotype correlation. subjected 11 patients who were diagnosed by chance routine medical health checkup. Most cases had past history of fracture. Bone mineral density showed low or lower normal limit. Four six also high levels ionized Ca. In cases, four urinary Ca excretion. Nephrocalcinosis is found five...
Abstract Background Tumour-infiltrating lymphocyte (TIL)-high breast tumours have a high rate of pathological complete response (pCR) with neoadjuvant chemotherapy. In our routine diagnoses biopsy specimens from pCR cases, we observed infiltration plasma cells (PCs). A positive correlation PCs favourable patient outcome has recently been reported, but little is known about how contribute to local tumour immunity. Methods We retrospectively examined 146 patients invasive cancer who received...
Abstract Background Rating lymphocytes (TILs) are a prognostic marker in breast cancer and high TIL infiltration correlates with better patient outcomes. Meanwhile, parameters involving immune cells peripheral blood have also been established as markers. High platelet-to-lymphocyte ratios (PLRs) neutrophil-to-lymphocyte (NLRs) related to poor outcomes cancer, but their mechanisms remain unknown. To date, TILs these examined separately. Methods We investigated the relationship between...
To determine the predictive factors for postoperative urinary incontinence (UI) following holmium laser enucleation of prostate (HoLEP) during initial learning period.We evaluated 127 patients with benign prostatic hyperplasia who underwent HoLEP between January 2011 and December 2013. We recorded clinical variables, including blood loss, serum prostate-specific antigen levels, presence or absence UI. Blood loss was estimated as a decline in hemoglobina levels. The UI were determined using...
Macrophage infiltration of skin GVHD lesions correlates directly with disease severity, but the mechanisms underlying this relationship remain unclear and many macrophages is a therapeutic challenge. Here, we characterize involved in report that dexamethasone palmitate (DP), liposteroid, can ameliorate such by inhibiting macrophage functions. We found host-derived could exacerbate mouse model through expression higher levels pro-inflammatory TNF-α IFN-γ, lower anti-inflammatory IL-10 than...
Although nerve conduction study (NCS) using a standard electromyography system (EMGS) is considered to be the gold in evaluating diabetic polyneuropathy, this examination requires expensive equipment and well-trained technicians. We aimed validate point-of-care device, NC-stat/DPNCheck™, that has been developed for widespread use of NCS polyneuropathy.Diabetes patients underwent two kinds NCS: DPNCheck™ system. Inter-/intrarater reliability were also determined by intraclass correlation...
Gnetin-C is a naturally occurring stilbene derived from the seeds of Gnetum gnemon L., an edible plant native to Southeast Asia that called melinjo. Although biological properties and safety G. extract, which contains nearly 3% Gnetin-C, have been confirmed in various human studies, whether or not pure safe for humans unclear at present. We conducted randomized, double-blind, placebo-controlled trial. Healthy subjects were randomly divided into two groups. The interventional group (n = 6)...
<h3>Background</h3> Transient CD4<sup>+</sup> T cell depletion led to the proliferation of tumor-specific CD8<sup>+</sup> cells in draining lymph node and increased infiltration PD-1<sup>+</sup>CD8<sup>+</sup> into tumor, which resulted strong anti-tumor effects tumor-bearing mice. This is a first-in-human study IT1208, defucosylated humanized anti-CD4 monoclonal antibody, engineered exert potent antibody-dependent cellular cytotoxicity. <h3>Methods</h3> Patients with advanced solid tumors...