A5027874681- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Angiogenesis and VEGF in Cancer
- Urinary and Genital Oncology Studies
- Urinary Tract Infections Management
- Prostate Cancer Treatment and Research
- Pelvic floor disorders treatments
- Inflammatory mediators and NSAID effects
- Renal and related cancers
- Protease and Inhibitor Mechanisms
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Estrogen and related hormone effects
- Bee Products Chemical Analysis
- Peptidase Inhibition and Analysis
- Urologic and reproductive health conditions
- Eicosanoids and Hypertension Pharmacology
- Cell Adhesion Molecules Research
- Liver physiology and pathology
Nagasaki University
2014-2023
Nagasaki University Hospital
2005-2023
National Hospital
2022
Japanese Urological Association
2021
Nagoya Medical Center
2013-2019
National Hospital Organization
2013-2019
Multidisciplinary Digital Publishing Institute (Switzerland)
2019
Universitat de Miguel Hernández d'Elx
2019
University of Tübingen
2017
Queen's University
2011-2013
Sonic hedgehog (Shh) acts as a morphogen in many cell types. Recent studies have shown that signaling is involved vascular development well postnatal angiogenesis. However, the direct action of Shh on cultured endothelial cells has not been clearly shown. To address this issue, we examined effect morphological changes by murine brain capillary (IBE cells) and human umbilical (HUVECs). induced morphogenesis these cells. The was inhibited cyclopamine or pertussis toxin. Shh-induced also...
Abstract Purpose: Lymph vessel density (LVD) and microvessel (MVD) correlate with the malignant potential of tumors patient survival. Vascular endothelial growth factors (VEGF)-A, VEGF-C, VEGF-D could modulate LVD MVD. We investigated clinical prognostic significance MVD on lymphangiogenic angiogenic function VEGF-A, in human bladder cancer. Experimental Design: reviewed tissue samples from patients nonmetastatic cancer who had undergone transurethral resections (n = 126). The densities...
BACKGROUND Neoadjuvant hormonal therapy (NHT) is performed to improve the outcome in organ-confined prostate cancer. However, there little information regarding relationship between angiogenesis and NHT. The aim of this study was identify a suitable method evaluate angiogenic status tissue, determine prognostic value for biochemical recurrence patients who had undergone radical prostatectomy after METHODS We analyzed 108 formalin-fixed specimens from treated by prostatectomy. NHT...
Introduction Human antigen R (HuR) regulates the stability of mRNA and is associated with cell proliferation, angiogenesis, lymphangiogenesis. However, clinical significance pathological role HuR in bladder cancer remains unclear. The main objective this investigation was to clarify relationships between expression lymphangiogenesis, expressions cyclooxygenase (COX)-2 vascular endothelial growth factor (VEGF)-A, -C, -D. Methods All were examined by immunohistochemical techniques 122...
To clarify the relationships between daily salt intake and lower urinary tract symptoms.A cross-sectional clinical study was carried out with 728 patients. Spot urine samples were collected to evaluate estimated intake. The patients divided into two groups based on mean (9.2 g/day). Their condition evaluated using Core Lower Urinary Tract Symptoms score 3-day frequency volume charts. influence of symptoms investigated multivariate logistic regression analysis.Daytime (Q1) nocturia (Q2) in...
Abstract Purpose: The expression of matrix metalloproteinase-7 (MMP-7) correlates with the malignant potential various tumors and patient survival. We investigated clinical prognostic significance MMP-7 in cancer cells endothelial human renal cell carcinoma (RCC). Experimental Design: reviewed tissue samples 156 patients RCC who had undergone radical operation. was examined by immunohistochemistry. Sections containing MMP-7-positive vessels were also stained for CD34. density determined a...
Abstract The angiopoietin (Ang)/Tie2 system is implicated in blood vessel formation and maturation. However, the mitogenic effects of angiopoietins remain to be elucidated. Here, we show that Ang1 for cultured endothelial cells. dose-dependently induced proliferation increased labeling index a murine brain capillary cell line, IBE also human umbilical vein cells (HUVEC). up-regulated expression cyclin D1 both these activated mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase...
Abstract Purpose: Hepatocyte growth factor receptor (HGFR/c-Met) signaling is associated with tumor progression in various cancers. The clinical significance and pathologic roles of phosphorylated HGFR/c-Met renal cell carcinoma (RCC) are not fully understood; therefore, this study sought to clarify the possible role two tyrosine residues (pY1234/pY1235 pY1349) HGFR/c-Met. Experimental Design: kinetics phosphorylation at these was examined a human line, ACHN cells. In addition, expression...
Angiogenesis plays an important role in cancer progression many types of cancer. Evaluation angiogenesis is often performed, but the optimal methodology for human has not been agreed upon. As adequate evaluation tissues might be prediction prognosis and treatment decisions, we evaluated semiquantitatively by assessing microvessel density (MVD) urothelial upper urinary tract (UC-UUT). We compared performance three endothelial cell markers (CD31, CD34, CD105) on formalin-fixed from 122...
Heme oxygenase (HO)-1 is upregulated in malignancies and, turn, regulates other cancer-related factors. Although HO-1 expression has been associated with cigarette smoking under various pathologic conditions, little known about their association patients bladder cancer. was assessed 215 formalin-fixed cancer specimens by immunohistochemistry. Microvessel density, lymph vessel density (LVD), proliferation index (PI), and of the vascular endothelial growth factor (VEGF)-A, -C, -D,...
Limited information is available on the pathologic significance of human antigen R (HuR) in prostate cancer (PCa). The main aim this study was to clarify relationship between HuR expression and malignant aggressiveness, outcome, cancer-related molecules PCa. In vitro proliferation, colony formation, migration assays were performed LNCaP PC-3 cells. knocked down (KD) using small interfering RNA. relationships vascular endothelial growth factors (VEGFs), cyclooxygenase (COX)-2, heme oxygenase...