A5050794980- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Renal and related cancers
- Urinary Tract Infections Management
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Bee Products Chemical Analysis
- Inflammatory mediators and NSAID effects
- Oral microbiology and periodontitis research
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- Eicosanoids and Hypertension Pharmacology
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Adrenal and Paraganglionic Tumors
- Urological Disorders and Treatments
- Hormonal Regulation and Hypertension
- Phytoestrogen effects and research
- Esophageal Cancer Research and Treatment
Nagasaki University Hospital
2021-2025
Nagasaki University
2014-2025
University of Nagasaki
2024
Japanese Red Cross Society, Japan
2019
Sasebo City General Hospital
2018
BACKGROUND Neoadjuvant hormonal therapy (NHT) is performed to improve the outcome in organ-confined prostate cancer. However, there little information regarding relationship between angiogenesis and NHT. The aim of this study was identify a suitable method evaluate angiogenic status tissue, determine prognostic value for biochemical recurrence patients who had undergone radical prostatectomy after METHODS We analyzed 108 formalin-fixed specimens from treated by prostatectomy. NHT...
Introduction Human antigen R (HuR) regulates the stability of mRNA and is associated with cell proliferation, angiogenesis, lymphangiogenesis. However, clinical significance pathological role HuR in bladder cancer remains unclear. The main objective this investigation was to clarify relationships between expression lymphangiogenesis, expressions cyclooxygenase (COX)-2 vascular endothelial growth factor (VEGF)-A, -C, -D. Methods All were examined by immunohistochemical techniques 122...
Heme oxygenase (HO)-1 is upregulated in malignancies and, turn, regulates other cancer-related factors. Although HO-1 expression has been associated with cigarette smoking under various pathologic conditions, little known about their association patients bladder cancer. was assessed 215 formalin-fixed cancer specimens by immunohistochemistry. Microvessel density, lymph vessel density (LVD), proliferation index (PI), and of the vascular endothelial growth factor (VEGF)-A, -C, -D,...
Abstract Background Axitinib is a widely used tyrosine kinase inhibitor (TKI) in metastatic renal cell carcinoma (mRCC) treatment. Here, we analyzed the characteristics of patients who did not respond to axitinib and evaluated alternative options for their Methods We retrospectively data 449 with mRCC were administered following another TKI as initial therapy. Patients progressive disease (PD) at first assessment defined showing early-PD. risk early-PD relationship between treatment...
ABSTRACT Introduction Adrenal myelolipoma is often asymptomatic and commonly diagnosed using imaging modalities. Herein, we report a case of adrenal detected through spontaneous rupture review similar cases from the literature. Case Presentation A 27‐year‐old man was admitted to our hospital with sudden right flank pain. Abdominal computed tomography revealed retroperitoneal hemorrhage due tumor. He underwent emergency transcatheter arterial embolization because his severe symptoms poor...
Introduction: Testicular torsion (TT) and of the appendix testis or epididymis (TATE) are common causes acute scrotum, but differentiating them remains difficult. While meteorological factors have been linked to TT, their clinical significance is unclear. Methods We retrospectively analyzed TT TATE cases diagnosed via surgical exploration at Nagasaki university hospital (June 2018-March 2023). Clinical findings, seasonal variations, factors—including temperature, atmospheric pressure,...
Objective: To identify factors associated with preserved split renal function (SRF) after robot-assisted partial nephrectomy (RAPN). Patients and Methods: The study included patients who underwent RAPN at Nagasaki University Hospital between November 2016 December 2023. SRF was determined by 99mTc-dimercaptosuccinic acid imaging the estimated glomerular filtration rate, measurements obtained before 6 months surgery. ipsilateral parenchymal volume (IPV) measured same time. More than 90%...
Limited information is available on the pathologic significance of human antigen R (HuR) in prostate cancer (PCa). The main aim this study was to clarify relationship between HuR expression and malignant aggressiveness, outcome, cancer-related molecules PCa. In vitro proliferation, colony formation, migration assays were performed LNCaP PC-3 cells. knocked down (KD) using small interfering RNA. relationships vascular endothelial growth factors (VEGFs), cyclooxygenase (COX)-2, heme oxygenase...
Background/Aim: The primary objective of this study was to identify predictors for biochemical recurrence (BCR) within 2 years following robot-assisted radical prostatectomy (RARP). Identifying will enable insights that enhance personalized patient management and facilitate the ongoing refinement postoperative therapy strategies. Patients Methods: This retrospective included patients undergoing RARP from September 2014 January 2021. Exclusion criteria were preoperative endocrine therapy, BCR...
Heme oxygenase 1 (HO-1) is a stress‑response protein and its expression associated with malignant potential poor prognosis in several types of cancer. The present study investigated the association between HO‑1 levels pathological features, clinical outcomes other factors patients non‑muscle‑invasive bladder cancer (NMIBC). was evaluated using immunohistochemistry 147 formalin‑fixed tissue specimens. proliferation index, microvessel density, lymph vessel density cyclooxygenase (COX)‑2...
Abstract Primary bladder adenocarcinomas comprise 0.5–2% of all epithelial neoplasms. Of these, primary signet-ring cell carcinoma the is particularly rare, accounting for 0.24% malignancies. This tumor frequently diagnosed at an advanced stage and has a poor prognosis. No standard treatment yet been established. We here report patient in whom laparoscopic cystectomy following neoadjuvant chemotherapy was effective. Our 69-year-old man who had microscopic hematuria, undergone transurethral...
Background and Objectives: To examine the relationship between presence of earlobe crease (EC) overactive bladder (OAB). Materials Methods: The earlobes participants were examined macroscopically. ECs further divided into four groups (grades 0-3) according to severity. Subjective symptoms assessed using OAB symptom score (OABSS), objective findings uroflowmetry. these or absence severity EC was also examined. A ≥2 points on OABSS question 3 (urinary urgency), with a total ≥3 points,...
Cigarette smoking is a major risk factor for urothelial cancer (UC) development. However, the associations between and changes in pathological characteristics molecular expression of cancer-related molecules upper tract (UT) UC have not been fully elucidated. We investigated status factors, including cell proliferation, apoptosis, angiogenesis, lymphangiogenesis vascular endothelial growth factor-A -C, matrix metalloproteinase (MMP)-2 -9, cyclooxygenase (COX)-2 urokinase-type plasminogen...