A5100663992- Drug-Induced Adverse Reactions
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Eosinophilic Disorders and Syndromes
- Nonmelanoma Skin Cancer Studies
- Fungal Infections and Studies
- Lung Cancer Research Studies
- Reconstructive Facial Surgery Techniques
- Thyroid Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cytomegalovirus and herpesvirus research
- Blood Pressure and Hypertension Studies
- Herpesvirus Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Vector-Borne Animal Diseases
- T-cell and Retrovirus Studies
- Neuroendocrine Tumor Research Advances
- Parvovirus B19 Infection Studies
- Animal Disease Management and Epidemiology
- Inflammatory Myopathies and Dermatomyositis
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Response and Inflammation
- Health Systems, Economic Evaluations, Quality of Life
- Biosimilars and Bioanalytical Methods
University of Occupational and Environmental Health Japan
2020-2025
Sakai Municipal Hospital
2019-2025
Kagawa University
2024
Nagasaki University Hospital
2023
Harvard University
2023
Takatsuki General Hospital
2023
Hokkaido University
2001-2022
Hokkaido Institute of Public Health
2022
Kanazawa Municipal Hospital
2022
Nagasaki University
2019-2021
Background: Gingival melanin pigmentation may cause esthetic concerns, even if no serious medical problem is present. As an inhibitor of formation, ascorbic acid often used to treat skin pigmentation. Thus, the present study investigated effects on gingival in vitro and vivo. Methods: The formation were evaluated B16 mouse melanoma cells three‐dimensional human models. In addition, a clinical trial was performed investigate inhibitory gel containing 2‐glucoside (AS‐G gel) This double‐masked,...
Background: Telomerase reverse transcriptase (TERT) promoter mutations have been found in a subset of papillary thyroid carcinomas (PTCs) and are associated with tumor aggressiveness worse prognosis. However, little is known about the status TERT mRNA expression its relationship between clinicopathological features. Methods: We analyzed 159 PTC samples for using direct DNA sequencing. was measured quantitative transcription polymerase chain reaction. To examine low allelic frequency high...
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) has a high relapse rate. However, it typically remains confined to the skin and favorable long-term prognosis. We describe case of PC-ALCL that experienced in central nervous system (CNS). The patient presented with somatosensory abnormalities extremities after local treatment lesions was diagnosed CNS PC-ALCL. Methotrexate, procarbazine, vincristine therapy, alternating brentuximab vedotin, followed by autologous hematopoietic stem...
E-cadherin has been studied extensively in other systems but little attention paid to its role wound healing. We investigated expression epithelial healing vivo by focusing on the migrating cells tongue and mitotic non-injured side apart from original edge.Round full-thickness excisional wounds (6 mm diameter) incisional were prepared dorsally mice. On various days after operation, was examined immunohistochemical staining using a monoclonal antibody specific for E-cadherin.In both models,...
We reported that soluble tumour necrosis factor receptor type 2 (sTNFR2)/type 1 (sTNFR1) ratios in gingival crevicular fluid (GCF) decreased as the severity of chronic periodontitis (CP) increased. This study investigated effects periodontal treatment on TNF-alpha, sTNFR1 and R2 GCF serum CP patients.Thirty-five 90 samples were obtained from 35 patients (23 non-smokers 12 smokers) at baseline after treatment. The levels quantified by enzyme-linked immunosorbant assay.No significant...
Abstract Background Sedentary behavior and decreased physical activity are associated with reduced kidney function, yet most evidence is based on self-reported activity. This study investigated the association between accelerometer-based level function in a general Japanese population. Methods A cross-sectional was conducted 440 community-dwelling participants, aged 35–79 years. Time (min/d) assessed for following types of activity: sedentary behavior, light (LPA), moderate-to-vigorous...
Herpes zoster infection occurs more frequently and severely in immunosuppressed populations. However, the condition sometimes presents with atypical clinical manifestations of skin, which makes it difficult to reach a correct diagnosis. We experienced case acral gangrene caused by varicella virus (VZV)-related vasculitis rheumatoid arthritis (RA) patient. Histologically, necrotic was observed; however, there were initially no findings epidermis suggestive viral infection. thought that skin...
Necrotising fasciitis (NF) is a potentially lethal infection affecting subcutaneous tissue and superficial fascia that may progress to multiple organ failure, the prognosis often worse when host immunocompromised. The influenced by early diagnosis surgical debridement (1). Biologic therapies have been used in treating intractable inflammatory diseases, including collagen disorders. When using such treatment strategy, it critical be aware treated subject highly susceptible infection....
The authors report a method of reconstruction full-thickness lower eyelid defect using blepharoplasty technique utilizing excess skin the with hard palate mucosal graft. In all patients mucosa took well, and good functional aesthetic results were obtained. most suitable indication this might be for occurring horizontally (for which direct closure is difficult to apply) located in lateral side (when large amount can utilized). conclude that although shape size applied restricted, useful...
The authors report the use of calcium phosphate cement paste as a material for correction depression after nasal bone fracture, and evaluate its usefulness. Biopex® R (Mitsubishi Material Corporation, Tokyo, Japan) was used in this study (CPC), which developed Japan. CPC injection six patients (four women two men) with depressed nose deformity fracture. patients' ages ranged from 29 to 67 years (mean, 49 years), follow-up period 12 27 months. amount injected varied 0.5 2.5 mL, approximately....
The authors present their experience with 25 hard palate mucosa grafts used as lining material in the reconstruction of full-thickness alar defects. Good "take" was obtained 22 grafts; other three incurred necrosis overriding skin flaps and postoperative infection. Degree shrinkage 11 to 15 percent grafted size patients type defect that did not include margin; 26 35 included more than 50 margin. In all who had a good graft take, nasal cavities were maintained there no obstruction or...
Acute generalized exanthematous pustulosis (AGEP) is a rare and severe cutaneous adverse drug reaction characterized by the rapid development of numerous, small, nonfollicular, sterile pustules usually on an edematous, erythematous background.1 AGEP caused drugs—mainly antibiotics such as penicillin—and macrolides, recently has been found to be quinolones.2 Tosufloxacin fluoroquinolone developed in Japan that frequently prescribed for bronchitis or community-acquired pneumonia.
Cytomegalovirus (CMV) infection is one of the most common opportunistic viral infections in patients who are immunocompromised.1 In with multiple myeloma (MM), novel antimyeloma agents have improved outcomes; however, this has also led to an increase incidence by members Herpesviridae family, including CMV.2 We report a case involving anogenital skin ulcers related CMV-induced vasculopathy patient MM.
Abstract Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has been accepted as a treatment option for aggressive (acute or lymphoma type) adult T leukemia/lymphoma (ATLL) patients with poor prognosis, when suitable HLA-matched donor is not available. However, haplo-HSCT carries potential risk of treatment-related mortality including severe graft-versus-host disease (GVHD). Therefore, we conducted prospective pilot study in order to evaluate the efficacy and safety...
Abstract Mogamulizumab (MOG), a humanized monoclonal anti-CCR4 antibody, exerts strong antibody-dependent cellular cytotoxic effects on CCR4-positive adult T-cell leukemia/lymphoma (ATLL) cells. As CCR4 is highly expressed regulatory T cells as well ATLL cells, pre-transplant MOG induces severe graft-versus-host disease (GvHD). However, limited data are available post-transplant use of for relapsed ATLL. Here we describe the case patient with who experienced relapse involvement peripheral...