A5066600229- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Advancements in Transdermal Drug Delivery
- CAR-T cell therapy research
- Asthma and respiratory diseases
- Mast cells and histamine
- Toxin Mechanisms and Immunotoxins
- Cutaneous Melanoma Detection and Management
- Dermatologic Treatments and Research
- Lung Cancer Treatments and Mutations
- Pharmaceutical studies and practices
- Spondyloarthritis Studies and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Genetic and rare skin diseases.
- Skin Diseases and Diabetes
- Psoriasis: Treatment and Pathogenesis
Nara Medical University
2015-2024
Osaka University
2010-2022
Universitätsklinikum Erlangen
2011
Advanced Dermatology
2007
Recent studies have challenged the view that Langerhans cells (LCs) constitute exclusive antigen-presenting of skin and suggest dermal dendritic cell (DDC) network is exceedingly complex. Using knockin mice to track ablate DCs expressing langerin (CD207), we discovered dermis contains five distinct DC subsets identified their migratory counterparts in draining lymph nodes. Based on this refined classification, demonstrated quantitatively minor CD207+ CD103+ DDC subset endowed with unique...
The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe which include reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, toxic epidermal necrolysis. pharmacogenomic basis of phenytoin-related remains unknown.To investigate the genetic factors associated reactions.Case-control study conducted in 2002-2014 among 105 cases (n=61 syndrome/toxic necrolysis n=44 symptoms), 78 exanthema, 130 phenytoin-tolerant...
Abstract Subsets of dendritic cells (DCs) have been described according to their functions and anatomical locations. Conventional DC subsets are defined by reciprocal expression CD11b CD8α in lymphoid tissues (LT), CD103 non-LT (NLT). Spleen CD8α+ dermal CD103+ DCs share a high efficiency for Ag cross-presentation developmental dependency on specific transcription factors. However, it is not known whether all NLT-derived LT-resident similar despite different XCR1 was previously as...
Abstract Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms ( DIHS / DRESS ) is a severe adverse drug caused by specific drug. It characterized visceral organ involvement reactivation of various human herpesviruses. Although sporadic reports have documented certain conditions that appear after the resolution , little information available on sequelae in large patient population. The A sian Research Committee Severe Cutaneous Adverse Reactions,...
Abstract Skin-draining lymph nodes contain a number of dendritic cell (DC) subsets different origins. Some these are migratory, such as the skin-derived epidermal Langerhans cells and separate dermal DC subset, whereas others lymphoid resident in nature, CD8+ DCs found throughout tissues. In this study, we examine subset presentation self-Ag by migratory lymphoid-resident DCs, both steady state under conditions local skin infection. We show that is confined to migrating settings. Steady...
Abstract Tolerance to self‐antigens expressed in peripheral organs is maintained by CD4 + CD25 Foxp3 Treg cells, which are generated as a result of thymic selection or induction. Here, we demonstrate that steady‐state migratory DCs from the skin mediated conversion draining lymph nodes mice. These displayed partially mature MHC II int CD86 CD40 hi CCR7 phenotype, used endogenous TGF‐β for and showed nuclear RelB translocation. Deficiency alternative NF‐κB signaling pathway (RelB/p52) reduced...
Abstract Transgenic mice were generated to establish an animal model for T‐cell‐mediated autoimmune skin disease. A membrane‐bound form of OVA (mOVA) was specifically expressed under the control thekeratin 5 (K5) promoter in epidermal and hair follicular keratinocytes mice. Syngeneic, wild‐type rejected grafts K5‐mOVA with generation OVA‐specific CTL. To study CTL response against skin, we used OT‐I transgenic mice, which produce K b ‐restricted, CD8 + T cells. Accelerated rejection...
Abstract Stevens– J ohnson syndrome ( SJS ) and toxic epidermal necrolysis TEN are rare life‐threatening cutaneous adverse drug reactions. While there is no established therapy for / , systemic corticosteroids, plasma exchange i.v. immunoglobulin IVIG have been used as treatment. The efficacy of still controversial because total doses vary greatly from one study to another. aim this was evaluate the administrated 5 days consecutively, in an open‐label, multicenter, single‐arm patients with...
The impairment that pruritic skin diseases have on patient productivity at work, in the classroom, and daily activities is substantial needs to be characterized. objective of this study was determine how impact quality life (QOL), order improve measurement these endpoints allow influence treatment options including sedative non- antihistamines analyzed. effect antihistamine therapy were evaluated using Work Productivity Assessment Index-Allergy Specific Questionnaire. intensity itch QOL...
Thymoma-associated multi-organ autoimmunity is a rare, autoimmune disease that causes colitis, liver dysfunction and cutaneous graft-versus-host (GVH)-like skin damage. This paraneoplastic disorder may be due to inadequate T cell selection in the tumour environment of thymus. Although sporadic case reports have revealed its clinical features, little known about pathological mechanism. By comparing skin-infiltrating subsets with those GVH (GVHD) other inflammatory diseases, we sought...
To analyze immunoregulation of autoreactive T cells specific for epidermal skin antigens, we crossed transgenic mice expressing ovalbumin selectively in keratinocytes under the keratin 5 promoter (K5-mOVA) with a K(b)-restricted OVA-specific cell receptor transgene (OT-I). In athymic double-transgenic mice, OT-I developed extrathymically and, at 8-12 weeks age, initiated severe damage mimicking toxic necrolysis (TEN). contrast, euthymic showed thymic deletion cells, had few these periphery,...