A5021086837- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
- CAR-T cell therapy research
- Calcium signaling and nucleotide metabolism
- Viral Infections and Vectors
- Adenosine and Purinergic Signaling
- Diabetes and associated disorders
- vaccines and immunoinformatics approaches
- Inflammatory Bowel Disease
- Cellular transport and secretion
- Toxoplasma gondii Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Complement system in diseases
- Viral Infections and Outbreaks Research
- Cell Adhesion Molecules Research
- Vibrio bacteria research studies
- Microscopic Colitis
- Optimism, Hope, and Well-being
Inserm
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Centre International de Recherche en Infectiologie
2016-2025
Université Claude Bernard Lyon 1
2016-2025
École Normale Supérieure de Lyon
2014-2025
Fondation pour la Recherche Médicale
2018-2022
Université Toulouse III - Paul Sabatier
2007-2015
Weatherford College
2015
Centre de Physiopathologie de Toulouse-Purpan
2007-2015
Centre Hospitalier Universitaire de Toulouse
2009
Recent studies have challenged the view that Langerhans cells (LCs) constitute exclusive antigen-presenting of skin and suggest dermal dendritic cell (DDC) network is exceedingly complex. Using knockin mice to track ablate DCs expressing langerin (CD207), we discovered dermis contains five distinct DC subsets identified their migratory counterparts in draining lymph nodes. Based on this refined classification, demonstrated quantitatively minor CD207+ CD103+ DDC subset endowed with unique...
Peripheral T cell maintenance requires a survival signal delivered upon receptor (TCR)-major histocompatibility complex (MHC) molecule interaction. Since self-peptides play critical role in the intrathymic positive selection of mature TCR repertoire, we hypothesized an equally important persistence. We used mice with normal expression MHC class II molecules but restricted self-peptide complexity (H-2Mα−/−) to show that II-restricted specificity displays deficient H-2Mα−/− thymus shows...
Multiple sclerosis-associated retroviral element (MSRV) is a element, the sequence of which served to define W family human endogenous retroviruses. MSRV viral particles display proinflammatory activities both in vitro mononuclear cell cultures and vivo humanized SCID mice model. To understand molecular basis such properties, we have investigated inflammatory potential surface unit envelope protein (ENV-SU), fraction that poised naturally interact with host cells. We report this study ENV-SU...
A cytolytic T lymphocyte (CTL) clone that lyses many HLA-A2 melanomas was derived from a population of tumor-infiltrating lymphocytes an melanoma patient. The gene coding for the antigen recognized by this CTL identified transfection cDNA library. It is which has been reported to code N-acetylglucosaminyltransferase V (GnT-V). Remarkably, antigenic peptide encoded sequence located in intron. In contrast fully spliced GnT-V mRNA, found wide range normal and tumoral tissues, mRNA containing...
OBJECTIVE We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive this antigen are among earliest islet infiltrates. aimed study selection, activation, development of capacity these insulin-reactive T-cells. RESEARCH DESIGN AND METHODS generated receptor (TCR) transgenic mouse expressing cloned TCR Vα18/Vβ6 G9C8 clone. The mice were crossed TCRCα−/− so that majority...
Autophagy is a cell autonomous process allowing each individual to fight intracellular pathogens. can destroy pathogens within the cytosol, and elicit innate adaptive immune responses against microorganisms. Nevertheless, numerous have developed molecular strategies enabling them avoid or even exploit autophagy for their own benefit. IRGM (immunity-related GTPase family M) human protein recently highlighted its contribution upon infections. The physical association of with mitochondria...
Autophagy is a potent cell autonomous defense mechanism that engages the lysosomal pathway to fight intracellular pathogens. Several autophagy receptors can recognize invading pathogens in order target them towards for their degradation after fusion of pathogen-containing autophagosomes with lysosomes. However, numerous avoid or exploit autophagy, among which measles virus (MeV). This induces complete flux, required improve viral replication. We therefore asked how interferes during course...
Crohn disease (CD) is an inflammatory bowel whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures degradation and recycling of cytosolic components microorganisms. In a clinical translation perspective, monitoring autophagic activity patients will require some knowledge...
Viruses adapt and modulate cellular pathways to allow their replication in host cells. The catabolic pathway of macroautophagy, for simplicity referred as autophagy, is no exception. In this review, we discuss anti-viral functions both autophagy select components the machinery, how viruses have evaded them. Some use membrane remodeling ability machinery build compartments cytosol or efficiently egress from cells a non-lytic fashion. remodeled membranes can even be found viral particles...
Thymus-specific serine protease (TSSP) is a novel that may contribute to the generation of peptide repertoire presented by MHC class II molecules in thymus. Although TSSP deficiency has no quantitative impact on development CD4 T cells expressing polyclonal cell receptor (TCR) repertoire, OTII and Marilyn transgenic TCRs impaired TSSP-deficient mice. In this study, we assess role shaping functional endogenous analyzing response mice several protein antigens (Ags). responded normally most Ags...
Abstract Human melanomas are infiltrated by tumor‐reactive T lymphocytes. However, the ability of these cells to elicit a specific anti‐tumor response in vivo remains be established. Because lymphokine production is critical for cell functions, we have analyzed capacity melanoma‐specific tumor‐infiltrating lymphocyte (TIL) clones produce major lymphokines: interleukin‐2 (IL‐2), interferon‐γ (IFN‐γ) and interleukin‐4 (IL‐4), as well tumor necrosis factor (TNF), direct antigen presentation...
Type 1 diabetes is a chronic autoimmune disease in which genetic predispositions affect the immune system, leading to loss of T cell tolerance β cells and consequent cell-mediated destruction insulin-producing islet cells. Genetic studies have suggested that PRSS16 linked susceptibility locus extended HLA class I region humans. encodes what we believe be novel protease, thymus-specific serine protease (TSSP), shows predominant expression thymic epithelial suspected restricted role II...