A5101747943- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Advancements in Transdermal Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Transgenic Plants and Applications
- Atherosclerosis and Cardiovascular Diseases
- Microtubule and mitosis dynamics
- Allergic Rhinitis and Sensitization
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Lymphoma Diagnosis and Treatment
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Anesthesia and Neurotoxicity Research
- Protist diversity and phylogeny
- Immune Response and Inflammation
- Genetic and Kidney Cyst Diseases
- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Liver physiology and pathology
Kindai University
2016-2025
Sapporo Science Center
2017-2024
University of California, San Diego
2021-2023
Kyoto Prefectural University of Medicine
2015-2021
Kaneka (Japan)
2015-2021
Takasago (Japan)
2015-2021
Osaka University
2008-2016
Hiroshima University
1997-2014
Teikyo Heisei University
2012-2013
Okinawa Prefectural Agricultural Research Center
2013
Abstract Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture lung and airways, we profiled five proximal-to-distal locations healthy lungs depth using multi-omic single cell/nuclei (queryable at lungcellatlas.org ). Using computational data integration analysis, extend beyond suspension paradigm discover macro micro-anatomical compartments including...
Populations of CD8+ lung-resident memory T (TRM) cells persist in the interstitium and epithelium (airways) following recovery from respiratory virus infections. While it is clear that TRM airways are dynamically maintained via continuous recruitment new cells, there a vigorous debate about whether tissue-circulating effector (TEM) source these newly recruited cells. Here we definitively demonstrate lung not derived TEM circulation, but seeded continuously by interstitium. This process...
Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied the context pathogen clearance. Yet, whether immunomodulatory bacteria operate through IFN pathways to support intestinal tolerance remains elusive. Here, we reveal that commensal bacterium, Bacteroides fragilis, utilizes canonical antiviral modulate dendritic cells (DCs) and regulatory T cell (Treg) responses. Specifically, signaling is required...
The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin mainly produced activated CD8+ T and natural killer cells. Recent studies have shown that XCL1-antigen fusion proteins efficiently induce cell responses preferentially delivering antigens XCR1+ DCs. However, XCL1 per se was found a poor adjuvant for induction of responses. unique because lack one the two disulfide bonds commonly conserved in all other...
Abstract Regulation of intracellular pH is critically important for many cellular functions. The quantification proton extrusion in different types cells and physiological conditions pivotal to fully elucidate the mechanisms homeostasis. Here we show use gold nanoparticles (AuNP) create a high spatial resolution sensor measuring extracellular proximity cell membrane. We test on HepG2 liver cancer MKN28 gastric before after inhibition Na + /H exchanger. surface conjugation strategy conceived...
FoxP3
Abstract Conventional type 1 dendritic cells (cDC1s) play a crucial role in antitumor immunity through the induction and activation of tumor‐specific CD8 + cytotoxic T (CTLs). The chemokine XCL1 is major chemotactic factor for cDC1s its receptor XCR1 selectively expressed on cDC1s. Here, we investigated effect intratumoral delivery highly active form murine (mXCL1‐V21C/A59C) cDC1‐mediated using hydrophilic gel patch. patch containing mXCL1‐V21C/A59C increased cDC1 accumulation tumor masses...