A5103125741- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders
- Cell Adhesion Molecules Research
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatologic Treatments and Research
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- Allergic Rhinitis and Sensitization
- Inflammatory Myopathies and Dermatomyositis
- Diagnosis and Treatment of Venous Diseases
- Nail Diseases and Treatments
- Stress Responses and Cortisol
- Psoriasis: Treatment and Pathogenesis
- Hidradenitis Suppurativa and Treatments
- Cancer and Skin Lesions
- Wound Healing and Treatments
- Mast cells and histamine
- Hedgehog Signaling Pathway Studies
Osaka University
2009-2022
Daifuku (Japan)
2022
Osaka National Hospital
1995-1999
Keio University
1995
The impairment that pruritic skin diseases have on patient productivity at work, in the classroom, and daily activities is substantial needs to be characterized. objective of this study was determine how impact quality life (QOL), order improve measurement these endpoints allow influence treatment options including sedative non- antihistamines analyzed. effect antihistamine therapy were evaluated using Work Productivity Assessment Index-Allergy Specific Questionnaire. intensity itch QOL...
Abstract Safety, tolerability, pharmacokinetics and efficacy of bexarotene, a novel retinoid X receptor ( RXR )‐selective retinoid, were evaluated in Japanese patients with stage IIB – IVB relapsed/refractory IB IIA cutaneous T‐cell lymphomas CTCL ). This study was conducted as multicenter, open‐label, historically controlled, single‐arm phase I/II study. Bexarotene p.o. administrated once daily at dose 300 mg/m 2 for 24 weeks 13 patients, following an evaluation safety tolerability 4 150...
Abstract Pilomatrix carcinoma is a rare malignant counterpart of pilomatricoma. To our knowledge, only approximately 90 cases have been published in English literature. locally aggressive and occasionally shows rapid progression infiltrating to the muscle, bone vessels. We report case pilomatrix that developed 38‐year‐old man started grow after long stable period, relapsed for short time infiltrated into muscle underneath. While initial skin biopsy showed histopathological findings...
Abstract In 2010, the first Japanese edition of guidelines for management cutaneous lymphoma was published jointly by J apanese D ermatological A ssociation ( JDA ) and S kin C ancer ociety JSCS – L ymphoma tudy G roup. Because were revised in 2011 based on most recent data, we summarized English two reasons: (i) to inform overseas clinicians about our way managing common types lymphomas such as mycosis fungoides/ ézary syndrome; (ii) introduce peculiar sia, adult T ‐cell leukemia/lymphoma...
Abstract A multisite, open‐label, non‐randomized, single‐arm phase II study was conducted to evaluate the efficacy and safety profiles of interferon‐γ in J apanese patients diagnosed with stage IA – IIIA mycosis fungoides ( MF ). Interferon‐γ administrated i.v. 15 at a dose 2 million Japan reference units once daily over 5 days week for first 4 weeks, followed by subsequent intermittent injection. The primary end‐point overall skin response during as assessed according evaluation criteria...
Glucocorticoids (GCs) are one of the most effective anti-inflammatory drugs for treating acute and chronic inflammatory diseases. However, several studies have shown that GCs alter collagen metabolism in skin induce atrophy. Cortisol is endogenous GC released response to various stressors. Over last decade, extraadrenal cortisol production tissues has been reported. Skin also synthesizes through a de novo pathway an activating enzyme. 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) enzyme...
Abstract Background Herpes zoster (HZ), a reactivation of varicella virus manifested by skin blisters and neuralgia, can lead to postherpetic neuralgia in 10–20% affected subjects. Method In this study, cohort 764 patients with HZ was treated 1500 mg/day famciclovir for 7 days, zoster‐associated pain (ZAP) monitored monthly thereafter up 12 months until resolution achieved. Patients were questioned telephone, recorded using numerical rating scale (NRS, 0–10). Key results A total 751 (98.3%)...
Differential diagnosis of cutaneous T cell lymphoma (CTCL) and severe atopic dermatitis (AD) is often difficult because the similarity in their skin manifestations. However, such differentiation extremely important differences remedy prognosis. The aim this study was to investigate new, helpful diagnostic aids for distinguishing CTCL from AD. frequency forkhead box protein 3(+) (FoxP3(+)) regulatory cells (T(regs)) lesions evaluated among three populations. Serum-soluble interleukin-2...
The present study (B-1201 clinical trial) was conducted as a multicenter, open-label, single-arm phase II to evaluate the long-term safety, tolerability and efficacy of bexarotene. This enrolled 10 Japanese adults aged more than 20 years with cutaneous T-cell lymphoma (CTCL) who completed 24-week period B-1101 trial. objective response rate (ORR) 53.8% (95% confidence interval, 25.1-80.8). In early stage (IB), ORR 60% (3/5 cases). advanced (IIB IIIA), 57.1% (4/7 median time 58 days (range,...
Systemic sclerosis (SSc) is a heterogeneous disorder characterized by excessive fibrosis and microvascular damage to the skin various internal organs, including lungs, kidneys, oesophagus heart. Raynaud’s phenomenon an almost universal symptom of SSc; 95% patients are affected. Digital ulcers observed frequently, especially in intractable cases with severe phenomenon, there considerable morbidity, gangrene amputations (1). To date, no promising treatment for SSc that complicated digital...
Peculiar erythema known as annular associated with Sjögren's syndrome (AESS) can be differentiated from autoimmune and subacute cutaneous lupus erythematosus, both clinically histologically. However, there are no detailed investigations on immune competent cells infiltration.Preferential infiltration of interleukin-17-producing T helper (Th17) regulatory (Treg) into the labial salivary gland is reported to play a role in maintaining mucoepithelitis patients syndrome. In this study, we...
Abstract Background Cyclosporine A (CYA) is an immunosuppressive agent which being used in the treatment of increasingly wide range dermatologic diseases, but its use has been avoided carriers hepatitis C virus (HCV). Methods We administered small doses CYA (maximum, 3 mg/kg/day) for a long time to treat diseases one HCV‐antibody‐positive patient with no HCV‐RNA blood, amount and two patients large amounts blood. Results Skin lesions improved all patients, recurred upon complete or partial...
Abstract Background Paraneoplastic cutaneous disorders (PCDs) or dermadromes are skin conditions that have an association with internal malignancies but not themselves malignant. We report the first two cases of systemic anaplastic large cell lymphoma (s‐ALCL) accompanied by erythroderma and multiple leg ulcers as PCDs. Case 1. A 52‐year‐old Japanese man presented disseminated itchy papular erythemas which he had over his entire body for preceding 5 years later exacerbated to erythroderma....