A5091904750- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders
- Viral-associated cancers and disorders
- Cancer and Skin Lesions
- Wound Healing and Treatments
- Nonmelanoma Skin Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Disorders and Syndromes
- T-cell and Retrovirus Studies
- Inflammatory Myopathies and Dermatomyositis
- Histiocytic Disorders and Treatments
- Urticaria and Related Conditions
- Cutaneous Melanoma Detection and Management
- Hidradenitis Suppurativa and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Skin Diseases and Diabetes
- Oral Health Pathology and Treatment
- Pressure Ulcer Prevention and Management
- Nail Diseases and Treatments
- Immunotherapy and Immune Responses
- Systemic Sclerosis and Related Diseases
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
Fukushima Medical University
2015-2024
Kyoto University
2016
University of Tsukuba
2016
Kagoshima Medical Center
2011
National Hospital Organization
2011
Imperial Household Agency
1997-1998
Cancer Institute (WIA)
1994
<h3>Objectives</h3> To determine the pathogenic association of latent Epstein-Barr virus (EBV) infections with both typical hydroa vacciniforme (HV) and severe HV-like eruptions, to survey complications outcomes patients. <h3>Design</h3> Case series. <h3>Patients</h3> Twenty-nine patients HV or eruptions. <h3>Interventions</h3> In situ hybridization immunostaining biopsy specimens; extraction DNA samples from cutaneous lesions and/or peripheral blood mononuclear cells for EBV assay. <h3>Main...
© 2016 The Authors. doi: 10.2340/00015555-2212 Journal Compilation Acta Dermato-Venereologica. ISSN 0001-5555 Programmed cell death (PD)-1 is an immune checkpoint receptor expressed on antigen-stimulated T cells. Several types of anti-PD-1 antibodies have demonstrated a remarkable benefit for metastatic melanoma, with low incidence severe adverse events. A fully human antiPD-1 antibody, nivolumab, has been approved in Japan patients unresectable melanoma. We report here case melanoma lung...
Abstract Burns are a common type of skin injury encountered at all levels medical facilities from private clinics to core hospitals. Minor burns heal by topical treatment alone, but moderate severe require systemic management, and grafting is often necessary also for treatment. Inappropriate initial or delay may exert adverse effects on the subsequent course. Therefore, accurate evaluation severity initiation appropriate necessary. The Guidelines Management Burn Injuries were issued in March...
<h3>Objective:</h3> To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection. <h3>Design:</h3> Retrospective survey case series. <h3>Setting:</h3> University hospital medical center. <h3>Patients:</h3> Sixty-five patients lymphomas and related disorders. <h3>Main Outcome Measures:</h3> Detection EBV genes EBV-encoded small nuclear RNAs. <h3>Results:</h3> Evidence latent infection was demonstrated in 15...
Nivolumab (ONO-4538) is an anti-programmed death-1 specific monoclonal antibody, which has become a standard treatment for metastatic malignant melanoma. induces autoimmune adverse events, defined as immune-related events. Herein, we report case of nivolumab-induced thyroid dysfunction in the clinical setting. Fourteen patients were treated with nivolumab at our institute, three developed dysfunction, incidence higher than previously reported initial trials. Interestingly, one patient...
Abstract Safety, tolerability, pharmacokinetics and efficacy of bexarotene, a novel retinoid X receptor ( RXR )‐selective retinoid, were evaluated in Japanese patients with stage IIB – IVB relapsed/refractory IB IIA cutaneous T‐cell lymphomas CTCL ). This study was conducted as multicenter, open‐label, historically controlled, single‐arm phase I/II study. Bexarotene p.o. administrated once daily at dose 300 mg/m 2 for 24 weeks 13 patients, following an evaluation safety tolerability 4 150...
Abstract In 2010, the first Japanese edition of guidelines for management cutaneous lymphoma was published jointly by J apanese D ermatological A ssociation ( JDA ) and S kin C ancer ociety JSCS – L ymphoma tudy G roup. Because were revised in 2011 based on most recent data, we summarized English two reasons: (i) to inform overseas clinicians about our way managing common types lymphomas such as mycosis fungoides/ ézary syndrome; (ii) introduce peculiar sia, adult T ‐cell leukemia/lymphoma...
The nasal type, extranodal natural killer or T(NK/T)-cell lymphoma is usually associated with latent Epstein–Barr virus (EBV) infection. In order to elucidate the EBV gene expression patterns in vivo, we examined eight patients cutaneous EBV-related NK/T-cell lymphomas, including six a NK-cell phenotype and two T-cell phenotype. implication of skin lesions was determined by presence EBV-DNA, EBV-encoded nuclear RNA (EBER) clonality EBV-DNA fragments containing terminal repeats. Transcripts...
Typical skin rash, which appears and disappears along with respective rise fall of fever, is well-known, included as one the major criteria adult-onset Still's disease (AOSD) (Yamaguchi's criteria). In addition, various lesions are occasionally observed in association AOSD. Persistent pruritic eruptions present some clinical features, such urticarial erythema, flagellate erythematous, slightly scaly or crusted papules, and/or plaques on trunk extremities. These show unique histological...
Abstract The Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings dermatological care. Skin diseases or vasculitis occur background a wide variety including, typically, systemic sclerosis but also lupus erythematosus ( SLE ), dermatomyositis, rheumatoid arthritis RA various vasculitides and antiphospholipid antibody syndrome APS ). Therefore, preparing present...
Buruli ulcer, a severe skin infectious disease caused by Mycobacterium ulcerans, is prevalent in tropical and subtropical areas. Recently, cases of ulcer have been increasing Japan. All sporadic, to date the pathogenic organism has not detected materials from environment.Three members same family were seen with large indurated plaques on their face extremities winter 2010. Skin biopsy specimens lesions showed extensive necrosis deep dermis subcutaneous fat. Acid-fast bacilli each specimen...